INT163498

Context Info Confidence 0.68 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 2.04 Pain Relevance 1.50

transmembrane transport (Hcn3)

Anatomy Link Frequency neurons 4 Hcn3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat hCN2 6 100.00 HCN1 4 100.00 c fibre 12 99.84

Disease Link Frequency Relevance Heat Diabetes Mellitus 14 98.74 Ganglion Cysts 10 98.38 Diabetic Neuropathy 2 72.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Compared to the sham NG neurons, diabetes induced the expression of HCN2 in the A-fiber neurons besides overexpression of HCN1 and HCN3; and enhanced the expression of HCN2 and HCN3 in C-fiber neurons.

Positive_regulation (enhanced) of Gene_expression (expression) of HCN3 in neurons associated with ganglion cysts, c fibre, diabetes mellitus, hcn1 and hcn2

1) Confidence 0.68 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.02 Pain Relevance 0.76

Compared to the sham NG neurons, diabetes induced the expression of HCN2 in the A-fiber neurons besides overexpression of HCN1 and HCN3; and enhanced the expression of HCN2 and HCN3 in C-fiber neurons.

Positive_regulation (overexpression) of Gene_expression (overexpression) of HCN3 in neurons associated with ganglion cysts, c fibre, diabetes mellitus, hcn1 and hcn2

2) Confidence 0.49 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.02 Pain Relevance 0.75

General Comments

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