INT1635

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1979
Last Reported 2011
Negated 10
Speculated 7
Reported most in Body
Documents 245
Total Number 253
Disease Relevance 53.36
Pain Relevance 88.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
neurons 23
plasma 13
macrophages 9
nerve 8
pituitary 8
Vip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 1112 100.00 Very High Very High Very High
Neuropeptide 650 100.00 Very High Very High Very High
substance P 424 100.00 Very High Very High Very High
Somatostatin 330 100.00 Very High Very High Very High
Enkephalin 322 100.00 Very High Very High Very High
Calcitonin gene-related peptide 196 100.00 Very High Very High Very High
Serotonin 106 100.00 Very High Very High Very High
qutenza 105 100.00 Very High Very High Very High
Cholecystokinin 76 100.00 Very High Very High Very High
headache 48 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 110 100.00 Very High Very High Very High
Headache 46 100.00 Very High Very High Very High
Celiac Disease 6 100.00 Very High Very High Very High
Pulmonary Hypertension 268 99.98 Very High Very High Very High
Increased Venous Pressure Under Development 71 99.98 Very High Very High Very High
Cancer 177 99.96 Very High Very High Very High
Polymyalgia Rheumatica 30 99.84 Very High Very High Very High
Parkinson's Disease 16 99.84 Very High Very High Very High
Arthritis 198 99.82 Very High Very High Very High
INFLAMMATION 705 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased expression of vasoactive intestinal polypeptide (VIP) in injured peripheral neurons was studied.
Gene_expression (expression) of VIP in peripheral neurons
1) Confidence 0.78 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2124338 Disease Relevance 0.19 Pain Relevance 0.35
Accompanying with the anti-inflammatory action, EA treatment resulted in an enhancement of VIP expression in the synovial tissue.
Gene_expression (expression) of VIP associated with inflammation and electroacupuncture
2) Confidence 0.78 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 1.13 Pain Relevance 0.95
Our data demonstrated that VIP likely act as an important mediator of the anti-inflammatory role of EA, which was supported by the findings that the EA treatment could markedly enhanced the expression of VIP in the synovial tissue, and moreover, the synovial VIP levels were negatively correlated with the inflammation scores.
Gene_expression (expression) of VIP associated with inflammation and electroacupuncture
3) Confidence 0.78 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 1.24 Pain Relevance 1.09
In conclusion, our results indicated, for the first time, that the EA treatment at Zusanli (ST 36), Xuanzhong (GB39), and Shenshu (BL23) could decrease the body weight loss and suppress the paw edema and inflammatory reaction in rats with Freund's adjuvant-induced arthritis, at least partially, via upregulating the VIP expression.
Gene_expression (expression) of VIP in body associated with pressure and volume under development, body weight, inflammation, electroacupuncture and arthritis
4) Confidence 0.78 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 1.14 Pain Relevance 0.70
The nervous system has been reported to be involved in the regulation of the pathogenesis of RA, through the production of several neuropeptides such as somatostatin, VIP, and calcitonin gene-related peptide [38].
Gene_expression (production) of VIP in nervous system associated with somatostatin, neuropeptide, rheumatoid arthritis and calcitonin gene-related peptide
5) Confidence 0.78 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 1.12 Pain Relevance 1.02
In addition, VIP was detected within large cells containing Rh-Lip corresponding to subcapsular sinus macrophages (Figure 5A-D).
Gene_expression (detected) of VIP in macrophages
6) Confidence 0.77 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
Immunofluorescence techniques combined with laser scanning confocal microscopy (LSCM) were used to investigate VIP and CRF expression in the duodenum.
Spec (investigate) Gene_expression (expression) of VIP in duodenum
7) Confidence 0.77 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 18023100 Disease Relevance 0.15 Pain Relevance 0
Our findings suggest that RTX can cause changes (messenger plasticity) in galanin, VIP and NOS expression in capsaicin-sensitive sensory neurones of the rat, similar to those described following axotomy.
Gene_expression (expression) of VIP associated with qutenza
8) Confidence 0.75 Published 1995 Journal Neuroreport Section Abstract Doc Link 8595209 Disease Relevance 0 Pain Relevance 0.19
Using in situ hybridization, the expression of mRNA encoding galanin, vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and nitric oxide synthase (NOS), respectively, was studied in lumbar dorsal root ganglia of rats given a single s.c. dose of 300 micrograms kg-1 resiniferatoxin (RTX), an ultrapotent capsaicin analogue.
Gene_expression (expression) of VIP in dorsal root ganglia associated with qutenza and neuropeptide
9) Confidence 0.75 Published 1995 Journal Neuroreport Section Abstract Doc Link 8595209 Disease Relevance 0 Pain Relevance 0.14
No VIP-IR or CGRP-IR was detectable in the sweat gland innervation at 4 or 7 days.
Neg (No) Gene_expression (detectable) of VIP-IR in sweat gland associated with calcitonin gene-related peptide
10) Confidence 0.74 Published 1988 Journal Dev. Biol. Section Abstract Doc Link 2893756 Disease Relevance 0 Pain Relevance 0.60
Nicotinic receptor agonists had no effect on pyramidal neurons and on most types of interneurons, including parvalbumin-expressing fast spiking interneurons and somatostatin-expressing interneurons, but selectively excited a subpopulation of interneurons coexpressing the neuropeptides vasoactive intestinal peptide (VIP) and cholecystokinin.
Gene_expression (coexpressing) of VIP in interneurons associated with pyramidal cell, neuropeptide, somatostatin, agonist and cholecystokinin
11) Confidence 0.73 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10377334 Disease Relevance 0 Pain Relevance 0.58
Neurons expressing VIP mRNA were mainly small sized, with a cross-sectional area of approximately 700 microns2, while those expressing GAL mRNA were both small (approximately 700 microns2) and medium (approximately 1,300 microns2) sized.
Gene_expression (expressing) of VIP mRNA in Neurons
12) Confidence 0.70 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7685398 Disease Relevance 0.07 Pain Relevance 0.81
Vasoactive intestinal polypeptide (VIP) is known to be expressed by inhibitory motor neurons in the gut, and it appears to be co-localized with nitric oxide synthase (NOS) in a subpopulation of enteric neurons.
Gene_expression (expressed) of VIP in neurons
13) Confidence 0.69 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7870287 Disease Relevance 0 Pain Relevance 0.12
Soluble VIP (green) was detected in the sinus of the LN (asterisks in Figure 5A,B,D).
Gene_expression (detected) of VIP in sinus
14) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
Thus, VIP detected in T lymphocytes could either represent VIP attached to its membranous receptor or VIP produced by T cells in response to VIP stimulation as previously reported [35].
Gene_expression (produced) of VIP in T cells
15) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.06 Pain Relevance 0.07
In animals that received an IVT injection of Rh-Lip that did not contain VIP, there was no VIP detectable in the subcapsular sinus of the cervical LN (data not shown).
Neg (no) Gene_expression (detectable) of VIP in sinus
16) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
VIP diffusing from VIP-Rh-Lip contained in ED3-positive macrophages could induce VIP production in adjacent T cells.
Gene_expression (production) of VIP in macrophages
17) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.06 Pain Relevance 0.08
In the cervical LN of VIP-Rh-Lip injected rats, VIP was detected in T lymphocytes.
Gene_expression (detected) of VIP in T lymphocytes
18) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.07 Pain Relevance 0.08
VIP was detected in the capsular sinus (asterisk in Figure 6A,B,D) and the LN parenchyma (Figure 6A,B,D).
Gene_expression (detected) of VIP in parenchyma
19) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0 Pain Relevance 0
In conclusion, an IVT injection of VIP encapsulated within liposomes provides long-term expression of VIP inside the eye and in the cervical LN draining the eye.
Gene_expression (expression) of VIP in eye
20) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox