INT163500

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.63
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal cord 2
neurons 1
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 10 99.68 Very High Very High Very High
long-term potentiation 23 99.08 Very High Very High Very High
Pain 12 98.28 Very High Very High Very High
intrathecal 2 93.52 High High
Cancer pain 14 92.04 High High
nMDA receptor antagonist 2 87.84 High High
Glutamate 2 84.48 Quite High
Anterior cingulate cortex 31 84.04 Quite High
Intractable pain 2 84.04 Quite High
Spontaneous pain 2 82.96 Quite High
Disease Link Frequency Relevance Heat
Cancer 8 98.60 Very High Very High Very High
Pain 14 98.28 Very High Very High Very High
Bone Cancer 10 97.76 Very High Very High Very High
Osteogenic Sarcomas 2 95.92 Very High Very High Very High
Cancer Pain 6 87.32 High High
Intractable Pain 2 84.04 Quite High
Hyperalgesia 2 81.52 Quite High
Neuropathic Pain 4 80.28 Quite High
Inflammatory Pain 2 79.44 Quite High
INFLAMMATION 6 65.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the different in the contribution of NR2B subunit and cingulate LTP, we did find many common features between the neurons of wild mice and that of laboratory mice.
Transcription (contribution) of NR2B in neurons associated with long-term potentiation
1) Confidence 0.67 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0.18 Pain Relevance 0.54
At day 14 after operation, the expression of NR2B mRNA and NR2B protein in the spinal cord were higher in tumor-bearing mice compared to the sham mice.
Transcription (expression) of NR2B in spinal cord associated with cancer and spinal cord
2) Confidence 0.53 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19815434 Disease Relevance 1.72 Pain Relevance 1.62
At day 14 after operation, the expression of NR2B mRNA and NR2B protein in the spinal cord were higher in tumor-bearing mice compared to the sham mice.
Transcription (expression) of NR2B protein in spinal cord associated with cancer and spinal cord
3) Confidence 0.53 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19815434 Disease Relevance 1.73 Pain Relevance 1.64

General Comments

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