INT163507

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Context Info
Confidence 0.51
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.96
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsk3a) signal transduction (Gsk3a) carbohydrate metabolic process (Gsk3a)
Anatomy Link Frequency
neurons 2
frontal cortex 2
Gsk3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 4 94.04 High High
antidepressant 5 91.24 High High
agonist 21 89.28 High High
Hippocampus 3 74.52 Quite High
Eae 1 69.96 Quite High
fluoxetine 1 62.56 Quite High
Glutamate 15 60.40 Quite High
Paracetamol 60 50.00 Quite Low
antagonist 12 5.00 Very Low Very Low Very Low
nMDA receptor 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 99.98 Very High Very High Very High
Urological Neuroanatomy 5 99.52 Very High Very High Very High
Depression 4 94.04 High High
Death 20 81.04 Quite High
Apoptosis 49 79.68 Quite High
Hypoxia 1 54.96 Quite High
Aging 38 50.00 Quite Low
Body Weight 4 41.12 Quite Low
Attention Deficit Hyperactivity Disorder 1 30.28 Quite Low
Frailty 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prenatal stress decreases glycogen synthase kinase-3 phosphorylation in the rat frontal cortex.
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of glycogen synthase kinase-3 in frontal cortex associated with stress and urological neuroanatomy
1) Confidence 0.51 Published 2009 Journal Pharmacol Rep Section Title Doc Link 19815943 Disease Relevance 0.67 Pain Relevance 0.38
Figure 5 show that pre-treatment with the PKC inhibitor Gö 6976 did not alter the loss in GSK3 phosphorylation levels induced by the PI3K inhibitor, but totally prevented the recovery mediated by BzATP, NMDA and BDNF.
Negative_regulation (loss) of Phosphorylation (phosphorylation) of GSK3
2) Confidence 0.12 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.08 Pain Relevance 0
The phosphorylation of the GSK-3 fusion protein at Ser21/Ser9 by the immunoprecipitated Akt was detected by immunoblotting.
Negative_regulation (detected) of Phosphorylation (phosphorylation) of GSK-3
3) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.05 Pain Relevance 0
The activation of these receptors in granule neurons led to a sustained pattern of GSK3 phosphorylation that was mainly PKC-dependent.
Negative_regulation (pattern) of Phosphorylation (phosphorylation) of GSK3 in neurons
4) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Abstract Doc Link PMC2858808 Disease Relevance 0.08 Pain Relevance 0.07
Pre-treatment with the MAPK inhibitor, U-0126, was also able to diminish BDNF-induced recovery in the levels of GSK3 phosphorylation (Fig. 5c).
Negative_regulation (diminish) of Phosphorylation (phosphorylation) of GSK3
5) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.07 Pain Relevance 0

General Comments

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