INT163529

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.37
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
brain 4
neuronal 2
spinal 2
hepatocytes 2
neurons 2
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 14 100.00 Very High Very High Very High
tolerance 13 99.28 Very High Very High Very High
Morphine 13 99.20 Very High Very High Very High
Antinociceptive 5 99.08 Very High Very High Very High
nMDA receptor antagonist 7 98.16 Very High Very High Very High
Inflammation 76 93.04 High High
nMDA receptor 13 92.64 High High
Spinal cord 16 87.96 High High
Dorsal horn 1 86.88 High High
Kinase C 43 78.88 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 153 100.00 Very High Very High Very High
Infection 82 100.00 Very High Very High Very High
Poisoning 19 99.98 Very High Very High Very High
Injury 90 99.70 Very High Very High Very High
Apoptosis 198 99.58 Very High Very High Very High
Insulin Resistance 26 96.00 Very High Very High Very High
INFLAMMATION 103 93.04 High High
Sepsis 63 92.28 High High
Stress 88 90.84 High High
Body Weight 56 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MK-801, a noncompetitive NMDA receptor antagonist, not only suppressed morphine antinociceptive tolerance and the increase in NR2B, but also reduced the spinal JNK activation induced by chronic morphine treatment.
Negative_regulation (reduced) of Positive_regulation (activation) of JNK in spinal associated with nmda receptor antagonist, tolerance, antinociceptive and morphine
1) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19818835 Disease Relevance 0 Pain Relevance 1.64
In addition, administration of arjunolic acid 4 h after acetaminophen intoxication reduced acetaminophen-induced JNK and downstream Bcl-2 and Bcl-xL phosphorylation, thus protecting against mitochondrial permeabilization, loss of mitochondrial membrane potential, and cytochrome c release.
Negative_regulation (reduced) of Positive_regulation (induced) of JNK associated with paracetamol and poisoning
2) Confidence 0.36 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19969075 Disease Relevance 0.63 Pain Relevance 1.01
Agmatine suppressed the hypoxia-induced activation of JNK and NF-?
Negative_regulation (suppressed) of Positive_regulation (activation) of JNK associated with hypoxia
3) Confidence 0.31 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 0.78 Pain Relevance 0
BDNF inhibited the activation of ERK (until 6 hours after hypoxia) and p38 (at 6 hours after hypoxia), while agmatine suppressed the activation of JNK (in significant amounts from 9 hours after hypoxia).


Negative_regulation (suppressed) of Positive_regulation (activation) of JNK associated with hypoxia
4) Confidence 0.31 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 0.94 Pain Relevance 0
Our data showing that atorvastatin inhibits JNK phosphorylation/activation in septic rats indicate that the beneficial effect of this drug in improving survival and reducing insulin resistance is mediated by different pathways.
Negative_regulation (inhibits) of Positive_regulation (activation) of JNK associated with insulin resistance
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.22 Pain Relevance 0.14
Selective suppression of JNK activation by agmatine
Negative_regulation (suppression) of Positive_regulation (activation) of JNK
6) Confidence 0.23 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 0.96 Pain Relevance 0
inhibitor blocked the As-induced JNK activation with a similar trend to the results of taurine treatment.
Negative_regulation (blocked) of Positive_regulation (activation) of JNK
7) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.23 Pain Relevance 0
and pre-treatment of hepatocytes with its inhibitor, rottlerin, suppressed the activation of JNK indicating that PKC?
Negative_regulation (suppressed) of Positive_regulation (activation) of JNK in hepatocytes
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935368 Disease Relevance 0.90 Pain Relevance 0
In addition, GSK3 cooperates and contributes to apoptotic signalling, such as JNK activation, during trophic deprivation [16].
Negative_regulation (deprivation) of Positive_regulation (activation) of JNK associated with apoptosis
9) Confidence 0.11 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.80 Pain Relevance 0.07
It has also been shown that activation of c-Jun N-terminal kinase (JNK), a kinase downstream of PKC [40], induces phosphorylation of RXR?
Negative_regulation (downstream) of Positive_regulation (activation) of JNK
10) Confidence 0.07 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.24 Pain Relevance 0.04
ATF3 is a member of the CREB family and its rapid expression after injury in neurons is preceded by a fast upregulation of JNK and phophorylation of c-jun [12,13,16].
Negative_regulation (preceded) of Positive_regulation (upregulation) of JNK in neurons associated with injury
11) Confidence 0.07 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.10 Pain Relevance 0
Minocycline suppresses JNK activation and lowers nitric oxide levels in the brain in SIV models of infection (Follstaedt et al. 2008), and, in parallel with this finding, minocycline suppresses NO-induced activation of p38 and JNK in vitro.
Negative_regulation (suppresses) of Positive_regulation (activation) of JNK in brain associated with infection
12) Confidence 0.06 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.64 Pain Relevance 0.13
Minocycline suppresses JNK activation and lowers nitric oxide levels in the brain in SIV models of infection (Follstaedt et al. 2008), and, in parallel with this finding, minocycline suppresses NO-induced activation of p38 and JNK in vitro.
Negative_regulation (suppresses) of Positive_regulation (activation) of JNK in brain associated with infection
13) Confidence 0.05 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.72 Pain Relevance 0.14
During growth factor deprivation induced PCD in neuronal PC12 cells, there is a sustained activation of the JNK and p38 pathways while the activities of ERK pathway is inhibited.
Negative_regulation (deprivation) of Positive_regulation (activation) of JNK in neuronal
14) Confidence 0.04 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.21 Pain Relevance 0.03

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