INT163535

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.35
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sgpp1) Golgi apparatus (Sgpp1) endoplasmic reticulum (Sgpp1)
Anatomy Link Frequency
forebrain 2
Sgpp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 1 99.48 Very High Very High Very High
abdominal pain 1 99.32 Very High Very High Very High
substance P 62 97.04 Very High Very High Very High
Morphine 13 94.24 High High
cytokine 20 91.44 High High
Dopamine 23 87.56 High High
Nucleus accumbens 19 87.44 High High
opioid receptor 1 84.48 Quite High
amygdala 4 80.96 Quite High
Inflammation 11 80.48 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 78 99.84 Very High Very High Very High
Abdominal Pain 1 99.32 Very High Very High Very High
Granuloma 92 99.00 Very High Very High Very High
Vomiting 2 98.56 Very High Very High Very High
Diarrhoea 1 97.84 Very High Very High Very High
Cognitive Disorder 44 97.72 Very High Very High Very High
Infection 12 88.40 High High
Cestode Infection 10 83.04 Quite High
INFLAMMATION 8 81.20 Quite High
Aids-related Complex 4 78.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon phosphorylation by protein kinase C, KEPI becomes a powerful inhibitor of protein phosphatase 1.
Negative_regulation (inhibitor) of phosphatase 1 associated with kinase c
1) Confidence 0.13 Published 2010 Journal Neuroscience Section Abstract Doc Link 19819304 Disease Relevance 0.17 Pain Relevance 0.45
, and IL-6 protein within granuloma obtained from T. crassiceps-infected WT and mice deficient in SPP or NK1.
Negative_regulation (deficient) of SPP associated with granuloma
2) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.44 Pain Relevance 0.57
OA is a potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A), enzymes that are known to be critical regulators of embryonic development.
Negative_regulation (inhibitor) of phosphatase 1
3) Confidence 0.06 Published 2010 Journal Toxicon Section Abstract Doc Link 20026154 Disease Relevance 0.39 Pain Relevance 0.10
On the one hand, the phosphorylation on Thr34 by protein kinase A (PKA) converts DARPP-32 into a selective inhibitor of serine/threonine protein phosphatase-1 (PP-1), thereby enhancing phosphorylation of proteins targeted by PP-1.
Negative_regulation (inhibitor) of phosphatase-1
4) Confidence 0.01 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.13 Pain Relevance 0.13
Conversely, forebrain expression of a calcineurin phosphatase inhibitor as well as nuclear protein phosphatase 1 inhibition in transgenic mice were both shown to enhance long-term object recognition memory (Malleret et al., 2001; Koshibu et al., 2009).
Negative_regulation (inhibition) of phosphatase 1 in forebrain associated with targeted disruption and cognitive disorder
5) Confidence 0.01 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.57 Pain Relevance 0
Conversely, forebrain expression of a calcineurin phosphatase inhibitor as well as nuclear protein phosphatase 1 inhibition in transgenic mice were both shown to enhance long-term object recognition memory (Malleret et al., 2001; Koshibu et al., 2009).
Negative_regulation (inhibitor) of phosphatase 1 in forebrain associated with targeted disruption and cognitive disorder
6) Confidence 0.01 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.58 Pain Relevance 0
Indeed, in its activated state as pThr34-DARPP-32, it becomes a robust inhibitor of protein phosphatase 1 (PP-1), a substrate responsible for de-phosphorylation of numerous cellular targets.
Negative_regulation (inhibitor) of phosphatase 1
7) Confidence 0.01 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.06 Pain Relevance 0.27

General Comments

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