INT163540

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 12.11
Pain Relevance 5.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (HYAL1) hydrolase activity, acting on glycosyl bonds (HYAL1) cell death (HYAL1)
extracellular region (HYAL1) carbohydrate metabolic process (HYAL1) lysosome (HYAL1)
Anatomy Link Frequency
synovium 9
chondrocytes 3
fibroblasts 3
sperm 3
plasma 1
HYAL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 207 99.48 Very High Very High Very High
Morphine 15 99.12 Very High Very High Very High
Osteoarthritis 670 98.84 Very High Very High Very High
rheumatoid arthritis 635 98.64 Very High Very High Very High
cINOD 27 98.08 Very High Very High Very High
Pain 38 93.32 High High
Arthritis 18 75.68 Quite High
metalloproteinase 22 63.20 Quite High
cytokine 104 60.88 Quite High
Potency 2 58.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 44 99.76 Very High Very High Very High
INFLAMMATION 234 99.48 Very High Very High Very High
Injury 61 98.92 Very High Very High Very High
Osteoarthritis 671 98.84 Very High Very High Very High
Rheumatoid Arthritis 635 98.64 Very High Very High Very High
Pain 22 93.32 High High
Arthropathy 59 93.20 High High
Arthritis 86 92.56 High High
Adhesions 22 87.56 High High
Wound Healing 11 63.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pharmacokinetics of SC morphine may be enhanced by coadministration with a hyaluronidase product.
Gene_expression (product) of hyaluronidase associated with morphine
1) Confidence 0.68 Published 2009 Journal J Pain Symptom Manage Section Abstract Doc Link 19819667 Disease Relevance 0.09 Pain Relevance 0.71
The mechanisms of chondroprotection by P. emblica fruit powder B (Fig. 3) and powder A, in human cartilage may in part be due to its hyaluronidase and gelatinase inhibitory activities (Figs 1 and 2).
Gene_expression (due) of hyaluronidase in cartilage
2) Confidence 0.31 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529383 Disease Relevance 0.56 Pain Relevance 0.17
Because obviously fibroblasts expressed PH-20 at the mRNA level, we used the anti-PH-20 antibodies to test whether these cells expressed the neutral-active hyaluronidase at the protein level.
Spec (whether) Gene_expression (expressed) of neutral-active hyaluronidase in fibroblasts
3) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0 Pain Relevance 0
Obviously, PH-20 produces angiogenic HA fragments, since cancer cell lines expressing this hyaluronidase induce angiogenesis in the cornea of mice whereas cancer cell lines lacking PH-20 mRNA do not [18].
Gene_expression (expressing) of hyaluronidase in cornea associated with cancer
4) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.42 Pain Relevance 0.11
Assays for hyaluronidase activity
Gene_expression (activity) of hyaluronidase
5) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0 Pain Relevance 0
It has been suggested that the nonsteroidal anti-inflammatory drugs, such as indomethacin, may exert a portion of their anti-inflammatory properties by inhibiting hyaluronidase and, hence, the generation of small HA fragments [56].
Gene_expression (generation) of hyaluronidase associated with inflammation and cinod
6) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.29 Pain Relevance 0.25
Chondrocytes, synoviocytes and dermal fibroblasts all express PH-20, a hyaluronidase active at neutral pH

Hyaluronan (HA), an important component of connective tissues, is highly metabolically active, but the mechanisms involved in its catabolism are still largely unknown.

Gene_expression (express) of hyaluronidase in fibroblasts
7) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Title Doc Link PMC1175024 Disease Relevance 0 Pain Relevance 0
The data reported herein strongly suggest, for the first time, that human chondrocytes, synoviocytes, and dermal fibroblasts all express, at both the mRNA and protein levels, a neutral-active hyaluronidase similar to PH-20.
Gene_expression (express) of neutral-active hyaluronidase in chondrocytes
8) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.06 Pain Relevance 0.05
Our study provides strong evidence that connective tissue cells express PH-20 and that the production of this neutral-active hyaluronidase is up-regulated by IL-1.
Gene_expression (production) of neutral-active hyaluronidase in connective tissue
9) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.52 Pain Relevance 0.17
We hypothesized that a protein similar to sperm PH-20, the only mammalian hyaluronidase known to be active at neutral pH, could be expressed in connective tissue cells.
Gene_expression (expressed) of hyaluronidase in sperm
10) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175024 Disease Relevance 0 Pain Relevance 0
Therefore, and although PH-20 mRNA has been detected only in testis, mouse kidneys, some cancer cell lines, and fetal and placenta cDNA libraries [18-21], we hypothesized that connective tissue cells may express a hyaluronidase similar to the one present on sperm.
Gene_expression (express) of hyaluronidase in testis associated with cancer
11) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.19 Pain Relevance 0.03
Herein we provide evidence that, at both the mRNA and protein levels, fibroblasts, chondrocytes, and synoviocytes all express a neutral, active hyaluronidase similar to sperm PH-20.


Gene_expression (express) of hyaluronidase in fibroblasts
12) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.17 Pain Relevance 0.03
The expression of the message for hyaluronidase-2 was significantly greater (400% of the control value), while the expression of messages for hyaluronidase-1 and hyaluronidase-3 was significantly decreased in RA synovium (to 40% and 3% of the respective control values) (Fig. 1).


Gene_expression (expression) of hyaluronidase in synovium associated with rheumatoid arthritis
13) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064865 Disease Relevance 0.59 Pain Relevance 0.29
Message expression for three isoforms of hyaluronan synthase and hyaluronidase in knee synovium differs in OA or RA from that in healthy controls.
Gene_expression (expression) of hyaluronidase in synovium associated with rheumatoid arthritis and osteoarthritis
14) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064865 Disease Relevance 1.51 Pain Relevance 0.71
Message expression of all three hyaluronidase isozymes was detected in all synovial samples.
Gene_expression (expression) of hyaluronidase
15) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064865 Disease Relevance 0.46 Pain Relevance 0.23
Hyaluronidase-1 may be present in the fluids, because it is a major isozyme in plasma and urine and is unable to bind hyaluronan at neutral pH [30].
Gene_expression (present) of Hyaluronidase-1 in urine
16) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064865 Disease Relevance 0.90 Pain Relevance 0.32
The expression of the message for hyaluronidase-2 was significantly greater (400% of the control value), while the expression of messages for hyaluronidase-1 and hyaluronidase-3 was significantly decreased in RA synovium (to 40% and 3% of the respective control values) (Fig. 1).


Gene_expression (expression) of hyaluronidase-1 in synovium associated with rheumatoid arthritis
17) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064865 Disease Relevance 0.58 Pain Relevance 0.29
Among five homologous isozymes in humans, hyaluronidase-1, -2, and -3 are thought to be expressed in synovium and involved in hyaluronan degradation, since hyaluronidase-4 is a chondroitinase and hyaluronidase-5, the sperm-specific enzyme PH-20, is specifically expressed in sperm [30].
Gene_expression (expressed) of hyaluronidase-1 in sperm
18) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064865 Disease Relevance 0.39 Pain Relevance 0.16
Message expression for hyaluronidase-2 in OA synovium was significantly increased (to 430% of that in control synovium), while no significant differences were observed for hyaluronidase-1 and hyaluronidase-3 message expression.
Gene_expression (expression) of hyaluronidase in synovium associated with osteoarthritis
19) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064865 Disease Relevance 0.58 Pain Relevance 0.29
Message expression for hyaluronidase-2 in OA synovium was significantly increased (to 430% of that in control synovium), while no significant differences were observed for hyaluronidase-1 and hyaluronidase-3 message expression.
Gene_expression (expression) of hyaluronidase-1 in synovium associated with osteoarthritis
20) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064865 Disease Relevance 0.58 Pain Relevance 0.29

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