INT163544

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 15.28
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Anatomy Link Frequency
brain 2
plasma 1
Notch 1
cardiomyocyte 1
microglia 1
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 182 99.76 Very High Very High Very High
positron emission tomography 77 93.48 High High
Inflammation 180 90.64 High High
imagery 183 89.76 High High
antagonist 10 82.92 Quite High
fibrosis 4 78.44 Quite High
cOX1 1 77.00 Quite High
Hippocampus 75 72.84 Quite High
amygdala 7 62.48 Quite High
Neurotransmitter 2 50.56 Quite High
Disease Link Frequency Relevance Heat
Disease 1996 100.00 Very High Very High Very High
Alzheimer's Dementia 356 100.00 Very High Very High Very High
Cognitive Disorder 150 100.00 Very High Very High Very High
Targeted Disruption 334 99.68 Very High Very High Very High
Frontotemporal Dementia 87 99.56 Very High Very High Very High
Body Weight 4 99.40 Very High Very High Very High
Dilated Cardiomyopathy 2 99.08 Very High Very High Very High
Myocardial Infarction 10 98.00 Very High Very High Very High
Amyloid Plaque 97 95.84 Very High Very High Very High
Apoptosis 88 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, exogenous PS1 NTF does not co-assemble with endogenous PS1 CTF.
PS1 Binding (endogenous) of
1) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.12 Pain Relevance 0
In many instances the physiological role for the identified interaction between the putative protein with PS1 or PS2 is not clearly defined.
PS1 Binding (interaction) of
2) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.56 Pain Relevance 0
Since the first prediction of a genetic link between PSEN1 and PSEN2 with Alzheimer's disease, many research groups from both academia and pharmaceutical industry have sought to unravel how pathogenic mutations in PSEN cause presenile dementia.
PSEN1 Binding (link) of associated with alzheimer's dementia and disease
3) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Abstract Doc Link PMC1513131 Disease Relevance 0.46 Pain Relevance 0
PSEN genes encode polytopic membrane proteins termed presenilins (PS1 and PS2), which function as the catalytic subunit of ?
PS1 Binding (termed) of
4) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Abstract Doc Link PMC1513131 Disease Relevance 0.64 Pain Relevance 0
The proximal C-terminus region PS1 holoprotein then binds to this subcomplex by interacting with nicastrin TM domain [66].
PS1 Binding (binds) of in proximal
5) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
These findings indicate that association between N- and C-terminal domains of PS1 holoprotein occurs prior to endoproteolysis; and following assembly, PS-derived NTF/CTF do not exchange between ?
PS1 Binding (association) of
6) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.07 Pain Relevance 0
As discussed below, PS1 and PS2 are subunits of a protein complex, termed ?
PS1 Binding (subunits) of
7) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 1.03 Pain Relevance 0
Altered conformation and proximity of PS1-derived fragments themselves or with the substrate APP were shown to be the possible cause for the pathogenic functions of FAD-associated PS1 variants.
PS1 Binding (associated) of associated with disease
8) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.55 Pain Relevance 0.08
In addition to Alzheimer's disease, several recent studies have linked PSEN1 to familiar frontotemporal dementia.
PSEN1 Binding (linked) of associated with frontotemporal dementia and disease
9) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Abstract Doc Link PMC1513131 Disease Relevance 0.75 Pain Relevance 0
Furthermore, exogenous PS1 NTF does not co-assemble with endogenous PS1 CTF.
PS1 Neg (not) Binding (assemble) of
10) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.13 Pain Relevance 0
During the final step in the assembly, PEN-2 associates with the complex by interaction with TM 4 of PS1 2 [67,68], concurrent with PS1 endoproteolysis.
PS1 Binding (interaction) of
11) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
42-lowering NSAIDs change the conformation of presenilin-1 and alter the interaction of APP and presenilin/?
presenilin Binding (conformation) of associated with cinod
12) Confidence 0.36 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.13 Pain Relevance 0.67
-secretase plays an essential role on AD pathogenesis, PS1 inactivation reduces significantly age-dependent A?
PS1 Binding (inactivation) of associated with disease
13) Confidence 0.36 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.18 Pain Relevance 0.05
A type I transmembrane protein termed Nicastrin, which is the mammalian homolog of aph-2, was identified simultaneously by biochemical methods as a protein bound to PS1 [54].
PS1 Binding (bound) of
14) Confidence 0.35 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.07 Pain Relevance 0
On the other hand, there is a possibility that PS1 indirectly regulates protein trafficking via its interaction with protein trafficking factors.
PS1 Binding (interaction) of
15) Confidence 0.35 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
Familial Alzheimer's disease-associated presenilin variants are thought to exert their pathogenic function by selectively elevating the levels of highly amyloidogenic A?
presenilin Binding (associated) of associated with disease
16) Confidence 0.32 Published 2006 Journal Mol Neurodegener Section Abstract Doc Link PMC1513131 Disease Relevance 0.78 Pain Relevance 0
PS1 and PS2 mutations are associated with a higher risk of dilated cardiomyopathy and heart failure in AD patients [14].
PS1 Binding (associated) of in heart associated with dilated cardiomyopathy, disease and myocardial infarction
17) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 2.17 Pain Relevance 0
To examine if individual mutation in APP or PS1 is capable of eliciting myocardial contractile dysfunction independently, cardiomyocyte mechanical function was assessed in the gender- and weight-matched mice with mutation of APP or PS1 (3 mice each, body weight?
PS1 Binding (mutation) of in cardiomyocyte associated with body weight
18) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.50 Pain Relevance 0.04
METHODS: We determined the induction potency and emergence time for isoflurane, halothane, and sevoflurane using the minimum alveolar anesthetic concentration for loss of righting reflex as an end point in 12- to 14-mo-old triple transgenic Alzheimer (3xTgAD) mice and wild type C57BL6 controls. 3xTgAD mice model AD by harboring three distinct mutations: the APP(Swe), Tau, and PS1 human transgenes, each of which has been associated with familial forms of human AD.
PS1 Binding (associated) of
19) Confidence 0.30 Published 2010 Journal Anesth. Analg. Section Body Doc Link 19820240 Disease Relevance 0.08 Pain Relevance 0
Comparison of in vitro [3H]PIB binding to human AD brain as well as PS1/APP brain demonstrated a high affinity [3H]PIB-binding site in AD brains but not in PS1/APP mouse brain.
PS1 Binding (binding) of in brain associated with disease
20) Confidence 0.30 Published 2008 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2755760 Disease Relevance 0.39 Pain Relevance 0.24

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