INT163545

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 39
Total Number 39
Disease Relevance 25.50
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
Anatomy Link Frequency
platelet 9
MCF 7 1
stromal cells 1
pericytes 1
fibroblasts 1
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 5 94.44 High High
fibrosis 108 94.24 High High
palliative 22 94.16 High High
Pain 72 89.44 High High
Analgesic 24 87.04 High High
Inflammation 24 83.92 Quite High
positron emission tomography 15 78.96 Quite High
cva 20 70.20 Quite High
corticosteroid 9 68.48 Quite High
cINOD 4 66.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 842 99.98 Very High Very High Very High
Chordoma 240 99.98 Very High Very High Very High
Metastasis 205 99.98 Very High Very High Very High
Glioma 106 99.98 Very High Very High Very High
Cervical Cancer 4 99.98 Very High Very High Very High
Glioblastoma 76 99.96 Very High Very High Very High
Breast Cancer 637 99.92 Very High Very High Very High
Apoptosis 254 99.80 Very High Very High Very High
Ovarian Cancer 262 99.74 Very High Very High Very High
Sarcoma 48 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical analysis of tumor tissue specimens obtained at initial surgery revealed ample expression of platelet-derived growth factor receptor (PDGFR)-b on stromal and endothelial cells.
Gene_expression (expression) of PDGFR in platelet associated with cancer
1) Confidence 0.78 Published 2010 Journal J. Neurooncol. Section Abstract Doc Link 19820899 Disease Relevance 1.01 Pain Relevance 0.09
Immunohistochemical analysis of tumor tissue specimens obtained at initial surgery revealed ample expression of platelet-derived growth factor receptor (PDGFR)-b on stromal and endothelial cells.
Gene_expression (expression) of platelet-derived growth factor receptor in platelet associated with cancer
2) Confidence 0.78 Published 2010 Journal J. Neurooncol. Section Abstract Doc Link 19820899 Disease Relevance 1.01 Pain Relevance 0.09
Although the ultimate mechanism of PDGFR overexpression remains unclear, we found ionizing radiation can upregulate PDGFR in fibroblasts.
Gene_expression (overexpression) of PDGFR in fibroblasts
3) Confidence 0.71 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.58 Pain Relevance 0.12
However, it is now evident that this agent has more than one target, including c-kit and PDGFR, which have been shown to be overexpressed in a subset of breast cancers and associated with poor prognosis [59].
Gene_expression (overexpressed) of PDGFR associated with breast cancer
4) Confidence 0.66 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.74 Pain Relevance 0.04
Proteins fibronectin 1 (FN1), integrin beta 1 (ITGB1) and platelet-derived growth factor receptor beta (PDGFRB) represent the top three 3 communication "hotpots" with the highest degree and traffic values in this network.
Gene_expression (represent) of PDGFRB in platelet
5) Confidence 0.65 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 0.19 Pain Relevance 0
As shown in figure 6, the expression of the tyrosine kinase receptor PDGFR ?
Gene_expression (expression) of PDGFR
6) Confidence 0.65 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.15 Pain Relevance 0
Immunohistochemistry revealed a broad PDGFR expression in breast cancer [20,21].
Gene_expression (expression) of PDGFR associated with breast cancer
7) Confidence 0.65 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 1.30 Pain Relevance 0
Epithelial cells do not express PDGF and PDGFR under physiological conditions.
Neg (not) Gene_expression (express) of PDGFR in Epithelial cells
8) Confidence 0.62 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.83 Pain Relevance 0.40
Others had shown that fibroblasts isolated from rat lungs over expressed PDGFR-?
Gene_expression (expressed) of PDGFR in lungs
9) Confidence 0.62 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.58 Pain Relevance 0.15
Successively, in a molecular/biochemical analyses of the three receptors targeted by IM (PDGFRB, PDGFRA, and KIT) in a series of 31 chordoma patients, it was proven that PDGFRB was highly expressed and phosphorilated whereas PDGFRA and KIT were less expressed but equally activated [14].
Gene_expression (expressed) of PDGFRB associated with chordoma
10) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2828414 Disease Relevance 0.63 Pain Relevance 0
Successively, in a molecular/biochemical analyses of the three receptors targeted by IM (PDGFRB, PDGFRA, and KIT) in a series of 31 chordoma patients, it was proven that PDGFRB was highly expressed and phosphorilated whereas PDGFRA and KIT were less expressed but equally activated [14].
Gene_expression (expressed) of PDGFR associated with chordoma
11) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2828414 Disease Relevance 0.63 Pain Relevance 0
In PDGFR expressing glioblastoma cells the addition of imatinib to irradiation induced a significant increase of cells undergoing apoptosis.
Gene_expression (expressing) of PDGFR associated with glioblastoma and apoptosis
12) Confidence 0.57 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.56 Pain Relevance 0
MCF 7 cells are positive for c-kit and PDGFR ?
Gene_expression (positive) of PDGFR in MCF 7
13) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.09 Pain Relevance 0
Importantly, RTK inhibitors could effectively attenuate this paracrine radiation-induced activation by blocking autophosphorylation of PDGFR and by downregulation of PDGFR expression.
Gene_expression (expression) of PDGFR
14) Confidence 0.55 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1458351 Disease Relevance 0.23 Pain Relevance 0.08
A trial is recruiting patients with PDGFR or c-kit over-expression to letrozole plus imatinib and will include a parallel biomarker analysis.


Gene_expression (expression) of PDGFR
15) Confidence 0.51 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.58 Pain Relevance 0.05
A trial is recruiting patients with PDGFR or c-kit over-expression to letrozole plus imatinib and will include a parallel biomarker analysis.


Gene_expression (over) of PDGFR
16) Confidence 0.51 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.58 Pain Relevance 0.05
Differences in PDGFR expression could not be detected, but receptor phosphorylation was significantly inhibited when treated with imatinib.
Gene_expression (expression) of PDGFR
17) Confidence 0.50 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2925350 Disease Relevance 0.37 Pain Relevance 0
So far only few groups have performed immunohistochemical analysis in primary breast cancers on PDGFR expression which plays an important role in autocrine and paracrine stimulation of cancer and stromal cells as well as in angiogenesis [13].
Gene_expression (expression) of PDGFR in stromal cells associated with cancer and breast cancer
18) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.60 Pain Relevance 0
All cell lines express PDGFR ?
Gene_expression (express) of PDGFR
19) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.09 Pain Relevance 0
An expression of PDGFR ?
Gene_expression (expression) of PDGFR
20) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.75 Pain Relevance 0

General Comments

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