INT16356

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Context Info
Confidence 0.62
First Reported 1987
Last Reported 2008
Negated 11
Speculated 6
Reported most in Abstract
Documents 33
Total Number 39
Disease Relevance 13.24
Pain Relevance 9.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NPPA) nucleus (NPPA) cytoplasm (NPPA)
Anatomy Link Frequency
plasma 13
veins 2
colon 1
brain 1
urine 1
NPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 42 100.00 Very High Very High Very High
noradrenaline 28 100.00 Very High Very High Very High
Neuropeptide 8 100.00 Very High Very High Very High
Catecholamine 6 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
bradykinin 1 99.92 Very High Very High Very High
narcan 11 99.84 Very High Very High Very High
opiate 10 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 110 100.00 Very High Very High Very High
Ocular Hypertension 12 99.80 Very High Very High Very High
Dyspnea 9 99.72 Very High Very High Very High
Obesity 22 98.76 Very High Very High Very High
Coronary Artery Disease 5 97.70 Very High Very High Very High
Heart Rate Under Development 12 97.36 Very High Very High Very High
Cv General 2 Under Development 46 96.64 Very High Very High Very High
Pulmonary Hypertension 7 94.40 High High
Hypertension 7 92.72 High High
Pheochromocytoma 4 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of clonidine and dihydralazine on plasma ANF and cyclic GMP levels in humans during volume loading.
Regulation (Effects) of ANF in plasma associated with clonidine
1) Confidence 0.62 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 2455172 Disease Relevance 0.10 Pain Relevance 0.51
ANF was serially determined in central venous plasma during all drug infusions, and plasma catecholamines were measured to determine any possible influence of endogenous sympathetic activation on ANF levels.
Spec (possible) Regulation (influence) of ANF in sympathetic associated with catecholamine
2) Confidence 0.62 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.15 Pain Relevance 0.22
Effects of clonidine and dihydralazine on atrial natriuretic factor and cGMP in humans.
Regulation (Effects) of atrial natriuretic factor associated with natriuresis and clonidine
3) Confidence 0.54 Published 1989 Journal J. Appl. Physiol. Section Title Doc Link 2551880 Disease Relevance 0.19 Pain Relevance 0.49
In the present work we have compared the effects of a 1-week oral application of clonidine (2 x 0.075 mg/day) to dihydralazine (2 x 25 mg/day) in eight healthy volunteers on changes in plasma ANF and plasma and urine cyclic GMP levels after acute volume loading with 2 I physiological saline i.v.
Regulation (effects) of ANF in plasma associated with clonidine
4) Confidence 0.45 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455172 Disease Relevance 0.10 Pain Relevance 0.33
Plasma ANF was unaffected by all individual drugs and drug combinations, despite significant reductions in CVP in the salbutamol, phentolamine and phentolamine + clonidine groups, and a doubling of heart rate during salbutamol administration (p less than 0.01 for all).
Neg (unaffected) Regulation (unaffected) of ANF in Plasma associated with clonidine
5) Confidence 0.45 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.14 Pain Relevance 0.22
The combination of these data suggests an important potential role for ANP in the mechanism of action of morphine in the treatment of acute left ventricular failure.
Regulation (role) of ANP associated with heart rate under development and morphine
6) Confidence 0.45 Published 1990 Journal Ann. Clin. Biochem. Section Abstract Doc Link 2138000 Disease Relevance 0.43 Pain Relevance 0.50
Effects of alpha-human natriuretic polypeptide (ANP) on isolated canine vascular strips were examined in 6 arteries and 5 veins.
Spec (examined) Regulation (Effects) of ANP in veins associated with natriuresis
7) Confidence 0.45 Published 1987 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2960841 Disease Relevance 0.17 Pain Relevance 0
The plasma levels of ANP and cGMP did not change after hyperventilation on days 1 and 3.
Neg (not) Regulation (change) of ANP in plasma associated with dyspnea
8) Confidence 0.45 Published 1993 Journal Am. J. Cardiol. Section Abstract Doc Link 8392283 Disease Relevance 0.98 Pain Relevance 0.36
It was concluded that under basal conditions opiate receptors are unable to modulate plasma ANP or serum aldosterone concentrations.
Neg (unable) Regulation (modulate) of plasma ANP in plasma associated with opiate
9) Confidence 0.45 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 2965206 Disease Relevance 0.23 Pain Relevance 0.35
Effects of atrial natriuretic factor (ANF) on intraocular pressure and aqueous humor flow in the cynomolgus monkey.
Regulation (Effects) of atrial natriuretic factor associated with natriuresis and ocular hypertension
10) Confidence 0.44 Published 1991 Journal Exp. Eye Res. Section Title Doc Link 1833216 Disease Relevance 0.59 Pain Relevance 0.09
Effects of atrial natriuretic factor (ANF) on intraocular pressure and aqueous humor flow in the cynomolgus monkey.
Regulation (Effects) of ANF associated with natriuresis and ocular hypertension
11) Confidence 0.44 Published 1991 Journal Exp. Eye Res. Section Title Doc Link 1833216 Disease Relevance 0.59 Pain Relevance 0.09
A significant positive correlation was found between changes in circulating noradrenaline (NA) levels and changes in atrial natriuretic peptide (ANP) levels during NA infusion and clonidine administration. 2.
Regulation (changes) of ANP associated with natriuresis, noradrenaline and clonidine
12) Confidence 0.43 Published 1987 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2959419 Disease Relevance 0.37 Pain Relevance 0.40
However, pharmacological PDE-3B inhibition or PDE-3B stimulation through insulin did not affect ANP-induced lipolysis in isolated adipocytes (32,34).
Neg (not) Regulation (affect) of ANP in adipocytes associated with obesity
13) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 0.38 Pain Relevance 0
In a randomized double blind placebo-controlled cross-over study we therefore examined the effect of 14-day GH administration (12 IU sc at 2000 h) on plasma volume, extracellular volume (ECV), atrial natriuretic peptide (ANP), arginine vasopressin, and the renin angiotensin system in eight healthy adult men.
Spec (examined) Regulation (effect) of ANP in plasma associated with natriuresis
14) Confidence 0.40 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1826008 Disease Relevance 0.27 Pain Relevance 0
Effects of alpha-human natriuretic polypeptide (ANP) on isolated canine vascular strips were examined in 6 arteries and 5 veins.
Spec (examined) Regulation (Effects) of natriuretic polypeptide in veins associated with natriuresis
15) Confidence 0.39 Published 1987 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2960841 Disease Relevance 0.17 Pain Relevance 0
A significant positive correlation was found between changes in circulating noradrenaline (NA) levels and changes in atrial natriuretic peptide (ANP) levels during NA infusion and clonidine administration. 2.
Regulation (changes) of natriuretic peptide associated with natriuresis, noradrenaline and clonidine
16) Confidence 0.38 Published 1987 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2959419 Disease Relevance 0.37 Pain Relevance 0.40
Compared to the time control study, naloxone had no effects on mean arterial pressure (MAP), plasma renin activity (PRA), aldosterone, catecholamines, atrial natriuretic peptide (ANP), glomerular filtration rate (GFR), estimated renal plasma flow (ERPF), and sodium excretion.
Neg (no) Regulation (effects) of ANP in plasma associated with natriuresis, catecholamine and narcan
17) Confidence 0.36 Published 1995 Journal Kidney Int. Section Abstract Doc Link 7474676 Disease Relevance 0.35 Pain Relevance 0.40
In a randomized double blind placebo-controlled cross-over study we therefore examined the effect of 14-day GH administration (12 IU sc at 2000 h) on plasma volume, extracellular volume (ECV), atrial natriuretic peptide (ANP), arginine vasopressin, and the renin angiotensin system in eight healthy adult men.
Spec (examined) Regulation (effect) of natriuretic peptide in plasma associated with natriuresis
18) Confidence 0.35 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1826008 Disease Relevance 0.27 Pain Relevance 0
Eight patients had no evidence of myocardial ischaemia, as measured by electrocardiographic and/or echocardiographic criteria, during dipyridamole infusion: among them, ANF values were similar while they were at rest and at peak dipyridamole administration (23.9 +/- 9.5 vs 23.4 +/- 6.9 pg ml-1, P = ns).
Regulation (values) of ANF associated with coronary artery disease
19) Confidence 0.27 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1830552 Disease Relevance 0.75 Pain Relevance 0.12
Pretreatment of opercular tissue with dibutyryl adenosine 3',5'-cyclic monophosphate, 8-bromoadenosine 3',5'-cyclic monophosphate, or 8-bromoguanosine 3',5'-cyclic monophosphate (10(-4) M) had no effect on the ANF stimulatory response.
Neg (no) Regulation (effect) of ANF associated with adenocard
20) Confidence 0.27 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2827529 Disease Relevance 0 Pain Relevance 0.14

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