INT16357

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 23
Total Number 26
Disease Relevance 12.37
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NPPA) nucleus (NPPA) cytoplasm (NPPA)
Anatomy Link Frequency
plasma 12
blood 2
brain 1
heart 1
respiratory 1
NPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 16 99.84 Very High Very High Very High
Catecholamine 5 95.60 Very High Very High Very High
cINOD 3 93.44 High High
Inflammation 11 91.28 High High
Pain 5 91.20 High High
anesthesia 6 90.08 High High
Paresthesia 3 89.88 High High
Opioid 3 89.52 High High
tetrodotoxin 2 87.36 High High
beta blocker 1 87.36 High High
Disease Link Frequency Relevance Heat
Cv General 2 Under Development 184 100.00 Very High Very High Very High
Natriuresis 78 100.00 Very High Very High Very High
Ocular Hypertension 16 100.00 Very High Very High Very High
Cancer 9 100.00 Very High Very High Very High
Body Weight 5 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Renal Failure 2 98.88 Very High Very High Very High
Coronary Heart Disease 15 98.52 Very High Very High Very High
Obesity 88 96.92 Very High Very High Very High
Pulmonary Hypertension 28 96.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Basal ANF was decreased to 65% in the clonidine group compared with both the control and dihydralazine groups.
Negative_regulation (decreased) of ANF associated with clonidine
1) Confidence 0.58 Published 1989 Journal J. Appl. Physiol. Section Abstract Doc Link 2551880 Disease Relevance 0.17 Pain Relevance 0.46
This increase in plasma ANP level was associated with a rapid decrease of atrial ANP, but not of ventricular ANP which on the contrary was significantly elevated at 120 min postinjection.
Neg (not) Negative_regulation (decrease) of ANP in plasma
2) Confidence 0.58 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996481 Disease Relevance 0.24 Pain Relevance 0.13
Our findings may also be important in terms of human pathophysiology, both in conditions associated with increased ANP and with decreased ANP availability.
Negative_regulation (decreased) of ANP
3) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 0.97 Pain Relevance 0
In summary, 14 days of high dose GH administration caused a significant increase in ECV and a significant suppression of ANP.
Negative_regulation (suppression) of ANP
4) Confidence 0.52 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1826008 Disease Relevance 0.34 Pain Relevance 0.14
In nine patients with renal failure routine haemodialysis was accompanied by a 30 per cent reduction in plasma ANP concentration.
Negative_regulation (reduction) of plasma ANP in plasma associated with renal failure
5) Confidence 0.51 Published 1987 Journal Clin Exp Hypertens A Section Abstract Doc Link 2957125 Disease Relevance 0.77 Pain Relevance 0.12
A significant decrease in plasma ANP (pmol/L) after GH administration was observed: 2.28 +/- 0.54 (GH), 3.16 +/- 0.53 (placebo) P less than 0.01.
Negative_regulation (decrease) of ANP in plasma
6) Confidence 0.45 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1826008 Disease Relevance 0.34 Pain Relevance 0.03
Plasma ANP level at rest decreases slightly after administration of naltrexone (32.8 +/- 6.3 pg/ml with placebo versus 21.3 +/- 4.6 pg/ml with naltrexone) but the response to physical exercise was significantly reduced by naltrexone (73.3 +/- 14.9 pg/ml with placebo versus 46.9 +/- 8.6 pg/ml with naltrexone) (p less than 0.05).
Negative_regulation (decreases) of Plasma ANP in Plasma
7) Confidence 0.45 Published 1989 Journal Pathol. Biol. Section Abstract Doc Link 2561015 Disease Relevance 0.22 Pain Relevance 0.37
Basal plasma ANF levels before infusion were decreased by clonidine to 65% of the untreated controls and remained unaltered with dihydralazine.
Negative_regulation (decreased) of ANF in plasma associated with clonidine
8) Confidence 0.43 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455172 Disease Relevance 0.09 Pain Relevance 0.46
Plasma ANF was unaffected by all individual drugs and drug combinations, despite significant reductions in CVP in the salbutamol, phentolamine and phentolamine + clonidine groups, and a doubling of heart rate during salbutamol administration (p less than 0.01 for all).
Neg (unaffected) Negative_regulation (unaffected) of ANF in Plasma associated with clonidine
9) Confidence 0.43 Published 1991 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 1850546 Disease Relevance 0.14 Pain Relevance 0.22
It was the objective of the present study to test the hypothesis that acute administration of low doses of ETOH would increase the plasma content of atrial natriuretic peptide (ANP), a hormone known to decrease blood pressure.
Negative_regulation (decrease) of ANP in blood associated with natriuresis
10) Confidence 0.42 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996481 Disease Relevance 0.27 Pain Relevance 0.10
Plasma ANF level at rest slightly decreased after administration of Naltrexone; the response to physical exercise was significantly reduced by Naltrexone.
Negative_regulation (decreased) of ANF in Plasma
11) Confidence 0.41 Published 1989 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 2555188 Disease Relevance 0.31 Pain Relevance 0.19
After closure, the plasma ANP concentrations decreased from 156.42 ± 75.10 ng/L to 101.78 ± 35.72 ng/L (p < 0.05), the RVEDV, RVESV decreased (P < 0.05), and the RVEF (P < 0.05) increased.


Negative_regulation (decreased) of plasma ANP in plasma
12) Confidence 0.39 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.72 Pain Relevance 0
The mechanism of ANP decreases may reflect a reduction of volume overload of right heart.
Negative_regulation (decreases) of ANP in heart
13) Confidence 0.39 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.28 Pain Relevance 0
The ratio decreased with both ANP (P = 0.05, one-way ANOVA) and placebo (P < 0.001, one-way ANOVA; data not shown), suggesting an increase in local blood flow with both treatments.
Negative_regulation (decreased) of ANP in blood
14) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 0.48 Pain Relevance 0
On ANP, the respiratory quotient decreased from 0.771 ± 0.016 at baseline to 0.735 ± 0.018 30 min after the meal (P < 0.05 compared with placebo).
Negative_regulation (decreased) of ANP in respiratory
15) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 0.12 Pain Relevance 0
46 patients with ASD underwent transcatheter closure of ASD, plasma ANP concentrations and 3DE measurements were measured before and 3 days after transcatheter closure of ASD with the Amplatzer septal occluder.
Negative_regulation (closure) of plasma ANP in plasma associated with cv general 2 under development
16) Confidence 0.39 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.75 Pain Relevance 0
In the postprandial phase, mean arterial pressure was significantly reduced with ANP infusion compared with placebo (P < 0.01, two-way ANOVA).
Negative_regulation (reduced) of ANP
17) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2584124 Disease Relevance 0.26 Pain Relevance 0
In this study, we showed that (1) plasma ANP concentrations were elevated in patients with ASD regardless of the presence of PAH, (2) plasma ANP concentrations were correlated positively with PAP, RVEDV and RVESV; and correlated negatively with RVEF, and (3) after transcatheter closure of ASD, plasma ANP concentrations were markedly decreased, the RVEDV, RVESV decreased and the RVEF increased markedly.
Negative_regulation (decreased) of plasma ANP in plasma associated with pulmonary hypertension and cv general 2 under development
18) Confidence 0.34 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2467405 Disease Relevance 0.62 Pain Relevance 0
Expansion of extracellular volume and suppression of atrial natriuretic peptide after growth hormone administration in normal man.
Negative_regulation (suppression) of natriuretic peptide associated with natriuresis
19) Confidence 0.33 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 1826008 Disease Relevance 0.28 Pain Relevance 0
The response to atrial natriuretic peptide was inhibited by (a) chloride-free solution on the serosal surface; (b) pretreatment of the tissues with the chloride channel blocker, diphenylamine-2-carboxylate (10(-3) M mucosally); (c) pretreatment with d,l-verapamil (10(-4) M mucosally and serosally); (d) calcium-free solution on the serosal surface; (e) pretreatment with tetrodotoxin (10(-7) M to serosal surface); and (f) pretreatment with atropine (10(-5) M serosally).
Negative_regulation (inhibited) of natriuretic peptide associated with natriuresis and tetrodotoxin
20) Confidence 0.32 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2153599 Disease Relevance 0.67 Pain Relevance 0.09

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