INT16359

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Context Info
Confidence 0.49
First Reported 1988
Last Reported 2011
Negated 3
Speculated 3
Reported most in Body
Documents 30
Total Number 33
Disease Relevance 28.27
Pain Relevance 6.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)
Anatomy Link Frequency
heart 10
plasma 5
sympathetic 4
renal artery 4
pigmented epithelial cells 3
AGT (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 26 100.00 Very High Very High Very High
cytokine 31 99.28 Very High Very High Very High
Inflammatory response 21 98.88 Very High Very High Very High
Inflammation 96 97.48 Very High Very High Very High
ischemia 32 97.44 Very High Very High Very High
fibrosis 34 97.36 Very High Very High Very High
substance P 11 96.28 Very High Very High Very High
Central nervous system 2 95.68 Very High Very High Very High
Migraine 12 95.44 Very High Very High Very High
Neuropeptide 7 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 328 100.00 Very High Very High Very High
Hypertension 210 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 88 100.00 Very High Very High Very High
Stress 42 99.52 Very High Very High Very High
Cv Unclassified Under Development 61 99.48 Very High Very High Very High
Pre-eclampsia 33 99.08 Very High Very High Very High
INFLAMMATION 141 98.70 Very High Very High Very High
Renal Artery Obstruction 2 98.52 Very High Very High Very High
Alkalosis 1 98.44 Very High Very High Very High
Syndrome 42 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The same stimulus also triggers an increase in the levels of circulating vasoactive hormones, such as norepinephrine and angiotensin II, further augmenting arteriolar tone.
Positive_regulation (increase) of Gene_expression (levels) of angiotensin II
1) Confidence 0.49 Published 1993 Journal Physiologist Section Abstract Doc Link 11537414 Disease Relevance 0.57 Pain Relevance 0.06
The rat and human renin-angiotensin systems do not interact, so the hypertension and vasculopathy exhibited by these rats is the result of the overexpression of the human renin-angiotensin system.
Positive_regulation (overexpression) of Gene_expression (overexpression) of angiotensin associated with hypertension
2) Confidence 0.49 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.92 Pain Relevance 0.20
Acute hypertension can result in an increase in afterload to the left ventricle, which may cause a reduction in the stroke volume, an elevation in the left ventricular filling pressure, and pulmonary congestion.13 The risk of myocardial ischemia, heart failure, stroke, neurocognitive dysfunction, renal failure, and bleeding are increased in patients with perioperative hypertension.14 In addition, adrenergic stimulation (occurring before, during, and after the operation) and activation of stress hormones and the renin–angiotensin system in both previously hypertensive and nonhypertensive patients may increase the risk of postoperative crises.8

Acute management of hypertensive emergencies and urgencies

Spec (may) Positive_regulation (increase) of Gene_expression (system) of angiotensin in ventricle associated with stress, heart rate under development, pressure and volume under development, coronary artery disease, renal failure, stroke, ischemia, hemorrhage, emergencies and hypertension
3) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922306 Disease Relevance 2.09 Pain Relevance 0.05
and components of the renin-angiotensin system (RAS) are expressed in the
Positive_regulation (components) of Gene_expression (expressed) of angiotensin
4) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 0.86 Pain Relevance 0.17
The mechanism of angioedema in patients taking ACEIs involves the inhibition of ACE, which blocks the conversion of angiotensin, reduces the catabolism of bradykinin, and increases its activity.10 Decreased aminopeptidase P (APP) activity and dipeptidyl peptidase P in the substance P degradation pathways also seem to play a role.11 Furthermore, a polymorphism of XPNPEP2 (the -2399 A variant), a candidate gene encoding membrane-bound APP, is associated with reduced APP activity and a higher incidence of ACEI-induced angioedema.12
Positive_regulation (increases) of Gene_expression (conversion) of angiotensin associated with pressure and volume under development, bradykinin and substance p
5) Confidence 0.49 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2892052 Disease Relevance 1.21 Pain Relevance 0.52
Interestingly, mast cells are capable of releasing renin and increasing local production of Angiotensin II.
Positive_regulation (increasing) of Gene_expression (production) of Angiotensin II in mast cells
6) Confidence 0.46 Published 2008 Journal Headache Section Abstract Doc Link 19076648 Disease Relevance 0.75 Pain Relevance 0.88
In patients taking ACE-inhibitors, the blunted production of angiotensin II and the consequent reduced stimulation of AT1- and AT2 receptor may induce an ‘escape phenomenon’, which consists in the accumulation of angiotensin I and production of angiotensin II through alternative synthetic bio-pathways (cathepsine C, chimases).10 This phenomenon, well described in patients with congestive heart failure, may be prognostically important.
Positive_regulation (accumulation) of Gene_expression (production) of angiotensin II in heart associated with heart rate under development
7) Confidence 0.46 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.84 Pain Relevance 0.12
In patients taking ACE-inhibitors, the blunted production of angiotensin II and the consequent reduced stimulation of AT1- and AT2 receptor may induce an ‘escape phenomenon’, which consists in the accumulation of angiotensin I and production of angiotensin II through alternative synthetic bio-pathways (cathepsine C, chimases).10 This phenomenon, well described in patients with congestive heart failure, may be prognostically important.
Positive_regulation (blunted) of Gene_expression (production) of angiotensin II in heart associated with heart rate under development
8) Confidence 0.46 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.99 Pain Relevance 0.13
In patients taking ACE-inhibitors, the blunted production of angiotensin II and the consequent reduced stimulation of AT1- and AT2 receptor may induce an ‘escape phenomenon’, which consists in the accumulation of angiotensin I and production of angiotensin II through alternative synthetic bio-pathways (cathepsine C, chimases).10 This phenomenon, well described in patients with congestive heart failure, may be prognostically important.
Spec (may) Positive_regulation (induce) of Gene_expression (production) of angiotensin II in heart associated with heart rate under development
9) Confidence 0.46 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.99 Pain Relevance 0.13
This culminates in angiotensin production, norepinephrine release, and arrhythmic cardiac dysfunction.
Positive_regulation (culminates) of Gene_expression (production) of angiotensin
10) Confidence 0.45 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20668055 Disease Relevance 0.23 Pain Relevance 0.56
Indomethacin reduced base-line and diuretic-induced increase in plasma renin activity, plasma angiotensin II levels and urinary excretion of prostaglandin 6-keto F1 alpha to a similar extent under the two sodium diets.
Positive_regulation (increase) of Gene_expression (levels) of angiotensin II in plasma
11) Confidence 0.42 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2703968 Disease Relevance 0.96 Pain Relevance 0.28
They also express ACE activity and provide a local source of angiotensin II production that is independent of systemic angiotensin II [22].
Neg (independent) Positive_regulation (independent) of Gene_expression (production) of angiotensin II
12) Confidence 0.35 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59642 Disease Relevance 0.78 Pain Relevance 0.20
Bartter's syndrome is a rare disorder characterized by normal or low arterial blood pressure (BP), despite marked elevation in plasma renin activity, angiotensin II (Ang-II), and aldosterone, along with hypokalemic metabolic alkalosis.
Positive_regulation (elevation) of in plasma Gene_expression (activity) of angiotensin II in blood associated with alkalosis and syndrome
13) Confidence 0.34 Published 1993 Journal J Clin Anesth Section Abstract Doc Link 8373612 Disease Relevance 0.59 Pain Relevance 0.28
Plasma aldosterone (pmol/L): 129 +/- 14 (GH), 89 +/- 17 (placebo), P = 0.08, and plasma angiotensin II (pmol/L) levels: 18 +/- 12 (GH), 14 +/- 7 (placebo), P = 0.21, were not significantly elevated.
Neg (not) Positive_regulation (elevated) of Gene_expression (levels) of angiotensin II in Plasma
14) Confidence 0.27 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1826008 Disease Relevance 0.45 Pain Relevance 0.11
In this review this is exemplified by overactivity of angiotensin II, vasopressin and cytokines in the brain during hypertension, heart failure and stress.
Positive_regulation (overactivity) of Gene_expression (overactivity) of angiotensin II in brain associated with stress, hypertension, myocardial infarction and cytokine
15) Confidence 0.26 Published 2006 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17244937 Disease Relevance 0.54 Pain Relevance 0.55
The important role RAS plays in pregnancy is further underlined by the fact that a preeclampsia-like model has been generated in female mice transfected with the human angiotensinogen gene and mated with males transfected with the human renin gene underlines this role[133].
Positive_regulation (transfected) of Gene_expression (transfected) of angiotensinogen gene associated with pre-eclampsia
16) Confidence 0.19 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.28 Pain Relevance 0.11
Thus, intravenous angiotensin infusion producing moderate increases in mean arterial pressure facilitates the ability of the carotid sinus baroreceptors to control mean arterial pressure and heart rate, and results in an increased overall vasoconstrictor capacity.
Positive_regulation (increases) of Gene_expression (producing) of angiotensin in heart
17) Confidence 0.18 Published 1988 Journal J. Hypertens. Section Abstract Doc Link 3183373 Disease Relevance 0.07 Pain Relevance 0.09
Similarly, when renal perfusion pressure is low, as in renal artery stenosis, the intraglomerular pressure necessary to drive filtration is, in part, mediated by increased intrarenal generation of angiotensin II to increase efferent arteriolar resistance.
Positive_regulation (mediated) of Gene_expression (generation) of angiotensin II in renal artery associated with renal artery obstruction
18) Confidence 0.13 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.34 Pain Relevance 0.17
Similarly, when renal perfusion pressure is low, as in renal artery stenosis, the intraglomerular pressure necessary to drive filtration is, in part, mediated by increased intrarenal generation of angiotensin II to increase efferent arteriolar resistance.
Positive_regulation (increased) of Gene_expression (generation) of angiotensin II in renal artery associated with renal artery obstruction
19) Confidence 0.13 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.33 Pain Relevance 0.17
Since ACE produces angiotensin II in the heart,
Positive_regulation (Since) of Gene_expression (produces) of angiotensin II in heart
20) Confidence 0.07 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.29 Pain Relevance 0.33

General Comments

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