INT1636

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Context Info
Confidence 0.77
First Reported 1976
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 58
Total Number 59
Disease Relevance 16.14
Pain Relevance 11.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sct)
Anatomy Link Frequency
plasma 7
duct 2
pancreatic duct 2
pancreas 2
endocrine cells 1
Sct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 23 100.00 Very High Very High Very High
Somatostatin 21 100.00 Very High Very High Very High
Neuropeptide 13 100.00 Very High Very High Very High
Cholecystokinin 9 100.00 Very High Very High Very High
Sciatic nerve 4 100.00 Very High Very High Very High
dorsal rhizotomy 4 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
imagery 11 99.86 Very High Very High Very High
lidocaine 7 99.66 Very High Very High Very High
Analgesic 5 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatic Veno-occlusive Disease 15 99.98 Very High Very High Very High
Heart Rate Under Development 21 99.84 Very High Very High Very High
Adhesions 26 99.76 Very High Very High Very High
Diabetes Mellitus 6 99.64 Very High Very High Very High
Hypocalcemia 1 99.48 Very High Very High Very High
Hemorrhagic Shock 4 99.42 Very High Very High Very High
Pancreatitis 75 99.28 Very High Very High Very High
Duodenal Ulcer 14 99.16 Very High Very High Very High
Disease 43 99.06 Very High Very High Very High
Malignant Neoplastic Disease 5 98.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression and motor effects of secretin in small and large intestine of the rat.
Gene_expression (Expression) of secretin in large intestine associated with neuropeptide
1) Confidence 0.77 Published 2000 Journal Peptides Section Title Doc Link 11090923 Disease Relevance 0 Pain Relevance 0.13
Using different approaches including sciatic nerve transection (SCT), L4-L6 dorsal rhizotomy (DRT) and local treatment of the sciatic nerve with capsaicin, we found that SCT, DRT, and local capsaicin onto the sciatic nerve produced a significant inhibition of the BV-induced increase in volume of the injected paw, with a stronger effect of the SCT and the local capsaicin treatments than that of the DRT treatment.
Gene_expression (produced) of SCT in sciatic nerve associated with qutenza, dorsal rhizotomy and sciatic nerve
2) Confidence 0.72 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16624301 Disease Relevance 0.90 Pain Relevance 1.49
The threshold dose was 2.8 pmol.kg-1.h-1, and the effective dose at 50% (ED50) was 5.6 pmol.kg-1.h-1, which produced physiological levels of plasma secretin.
Gene_expression (produced) of plasma secretin in plasma
3) Confidence 0.68 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7611400 Disease Relevance 0 Pain Relevance 0
Immunocytochemistry and in situ hybridization revealed abundant secretin expressing cells on duodenal villi with a gradual decrease throughout the small intestines of the rat.
Gene_expression (expressing) of secretin in small intestines
4) Confidence 0.67 Published 2000 Journal Peptides Section Abstract Doc Link 11090923 Disease Relevance 0 Pain Relevance 0.08
The mucoadhesion of poly(N-isopropylacrylamide) nanoparticles, which most strongly enhanced sCT absorption, was stronger than that of ionic nanoparticles, and poly(N-vinylacetamide) nanoparticles probably did not adhere to the GI mucosa.
Gene_expression (absorption) of sCT in poly
5) Confidence 0.67 Published 1999 Journal Int J Pharm Section Abstract Doc Link 10205611 Disease Relevance 0 Pain Relevance 0
Diffusion weighted images were obtained before and after secretin administration in all patients.
Gene_expression (administration) of secretin
6) Confidence 0.66 Published 2006 Journal Am. J. Gastroenterol. Section Body Doc Link 16405545 Disease Relevance 0.08 Pain Relevance 0
[Sonographic visualization of the pancreatic duct before and after secretin stimulation: an aid in the diagnosis of chronic pancreatitis].
Gene_expression (stimulation) of secretin in pancreatic duct associated with chronic pancreatitis
7) Confidence 0.66 Published 1985 Journal Ultraschall Med Section Title Doc Link 3892671 Disease Relevance 0.34 Pain Relevance 0.33
Ultrasound secretin test in patients with pancreas divisum--an aid in the diagnosis of papillary or dorsal duct stenosis?
Gene_expression (test) of secretin in pancreas associated with pathologic constriction
8) Confidence 0.66 Published 1999 Journal Z Gastroenterol Section Title Doc Link 10458006 Disease Relevance 0.28 Pain Relevance 0.09
Imaging after injection of secretin may add functional information to MRCP that may reflect one aspect of pancreatic exocrine physiology.
Gene_expression (injection) of secretin associated with imagery
9) Confidence 0.66 Published 1996 Journal Top Magn Reson Imaging Section Abstract Doc Link 8914227 Disease Relevance 0.45 Pain Relevance 0.14
In patients with anomalies of the pancreatic duct system, no uniform response was found after secretin injection.
Gene_expression (injection) of secretin in pancreatic duct
10) Confidence 0.66 Published 1989 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2648557 Disease Relevance 0.67 Pain Relevance 0.26
I.v. injection of secretin activates neurons in brain areas controlling autonomic function and emotion.
Gene_expression (injection) of secretin in autonomic
11) Confidence 0.62 Published 2004 Journal Neuroscience Section Abstract Doc Link 15450360 Disease Relevance 0 Pain Relevance 0.10
Reverse transcription polymerase chain reaction (RT-PCR) and quantitative real-time PCR showed that secretin receptor mRNA is expressed in the nodose ganglia and levels were higher in the right compared with the left ganglion.
Gene_expression (expressed) of secretin in ganglion associated with ganglion cysts
12) Confidence 0.62 Published 2004 Journal Neuroscience Section Abstract Doc Link 15450360 Disease Relevance 0.10 Pain Relevance 0.46
Experience with synthetic secretin in the treatment of duodenal ulcer.
Gene_expression (Experience) of secretin associated with duodenal ulcer
13) Confidence 0.62 Published 1976 Journal Am J Dig Dis Section Title Doc Link 790943 Disease Relevance 0.51 Pain Relevance 0.07
Plasma secretin levels in response to duodenal acidification were less in duodenal ulcer and the appearance of the maximal peak was delayed compared with that found in control.
Gene_expression (levels) of secretin in Plasma associated with duodenal ulcer
14) Confidence 0.60 Published 1978 Journal Gastroenterol. Jpn. Section Abstract Doc Link 648803 Disease Relevance 0.83 Pain Relevance 0.25
Infusion of HCl at 2 ml/h produced a physiological plasma secretin level and elicited a decrease in intragastric pressure of 3.0 +/- 0. 2 cmH20.
Gene_expression (produced) of secretin in plasma
15) Confidence 0.59 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10362654 Disease Relevance 0 Pain Relevance 0.19
Once extracts of secretin and cholecystokinin-pancreozymin became available from Sweden in the 1930s, it became possible for the biochemist Franklin Hollander and the surgeon David Dreiling to develop pancreatic secretion tests into practical procedures for the diagnosis of benign and malignant diseases of the pancreas and biliary tree, and produce physiological studies of the mechanisms of ion transport.
Gene_expression (extracts) of secretin in pancreas associated with malignant neoplastic disease, bile, disease and cholecystokinin
16) Confidence 0.59 Published 2000 Journal Mt. Sinai J. Med. Section Abstract Doc Link 10677785 Disease Relevance 0.23 Pain Relevance 0.10
The aim was to see whether specific binding sites for AMY and/or for sCT present in these areas could be relevant to some of the biological activities of the two peptides.
Gene_expression (present) of sCT
17) Confidence 0.59 Published 2000 Journal Brain Res. Section Abstract Doc Link 10784109 Disease Relevance 0.06 Pain Relevance 0.18
We conclude that synthetic porcine secretin is highly accurate and safe in pancreatic function testing.
Gene_expression (synthetic) of secretin
18) Confidence 0.58 Published 2000 Journal Pancreas Section Abstract Doc Link 11039470 Disease Relevance 0.24 Pain Relevance 0.14
MR pancreatograms were acquired before and every 30 seconds for 10 minutes after secretin injection.
Gene_expression (injection) of secretin
19) Confidence 0.58 Published 2000 Journal Radiology Section Body Doc Link 10796908 Disease Relevance 0 Pain Relevance 0
[Secretin-enhanced magnetic resonance cholangiopancreaticography: value for the diagnosis of chronic pancreatitis].
Gene_expression (enhanced) of Secretin associated with chronic pancreatitis
20) Confidence 0.58 Published 2007 Journal Rofo Section Title Doc Link 17594632 Disease Relevance 0.33 Pain Relevance 0.30

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