INT16364

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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2010
Negated 11
Speculated 11
Reported most in Abstract
Documents 234
Total Number 247
Disease Relevance 118.81
Pain Relevance 45.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRA) Golgi apparatus (HLA-DRA) endoplasmic reticulum (HLA-DRA)
plasma membrane (HLA-DRA) lysosome (HLA-DRA)
Anatomy Link Frequency
monocytes 63
T cells 26
CD86 12
epithelial cells 9
macrophages 6
HLA-DRA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 939 99.84 Very High Very High Very High
local anesthetic 49 99.80 Very High Very High Very High
Chronic pancreatitis 49 99.66 Very High Very High Very High
interstitial cystitis 45 99.64 Very High Very High Very High
Dismenorea 22 99.56 Very High Very High Very High
rheumatoid arthritis 476 99.34 Very High Very High Very High
chemokine 138 99.34 Very High Very High Very High
Inflammation 1797 99.28 Very High Very High Very High
Enkephalin 183 99.24 Very High Very High Very High
substance P 183 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 123 100.00 Very High Very High Very High
Endometriosis 55 100.00 Very High Very High Very High
Cancer 1035 99.86 Very High Very High Very High
Acute Liver Failure 60 99.84 Very High Very High Very High
Interstitial Nephritis 32 99.84 Very High Very High Very High
Necrosis 257 99.72 Very High Very High Very High
Hypersensitivity 137 99.70 Very High Very High Very High
Liver Disease 36 99.68 Very High Very High Very High
Duodenal Ulcer 10 99.68 Very High Very High Very High
Pancreatitis 566 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Immunohistochemical analysis revealed significantly increased expression of HLA-DR antigen in the glandular cells in eutopic and ectopic endometria, compared with materials from patients with adenomyoma and infertile patients.
Gene_expression (expression) of HLA-DR
1) Confidence 0.78 Published 1993 Journal Fertil. Steril. Section Body Doc Link 8224269 Disease Relevance 0.16 Pain Relevance 0
OBJECTIVE: To evaluate the expression of major histocompatibility complex class II antigen (human leukocyte antigen, HLA-DR) in glandular cells in eutopic and ectopic endometria in patients with endometriosis and adenomyosis.
Gene_expression (expression) of HLA-DR in leukocyte associated with endometriosis and dismenorea
2) Confidence 0.78 Published 1993 Journal Fertil. Steril. Section Abstract Doc Link 8224269 Disease Relevance 0.42 Pain Relevance 0.26
DESIGN: Glandular cells in eutopic and ectopic endometria were analyzed immunohistochemically to localize the expression of HLA-DR antigen.
Gene_expression (expression) of HLA-DR
3) Confidence 0.78 Published 1993 Journal Fertil. Steril. Section Body Doc Link 8224269 Disease Relevance 0.17 Pain Relevance 0
CONCLUSIONS: It is likely that aberrant expression of HLA-DR antigen in glandular cells of eutopic and ectopic endometria in endometriosis and adenomyosis is deeply involved in various immunological abnormalities.


Gene_expression (expression) of HLA-DR
4) Confidence 0.78 Published 1993 Journal Fertil. Steril. Section Body Doc Link 8224269 Disease Relevance 0.14 Pain Relevance 0
Experimental and clinical significance of endotoxin-dependent HLA-DR expression on monocytes.
Gene_expression (expression) of HLA-DR in monocytes
5) Confidence 0.78 Published 1989 Journal J. Surg. Res. Section Title Doc Link 2739399 Disease Relevance 0.06 Pain Relevance 0.10
LPS, added experimentally to whole blood, enhanced HLA-DR expression on monocytes without further manipulation.
Gene_expression (expression) of HLA-DR in monocytes
6) Confidence 0.78 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2739399 Disease Relevance 0.08 Pain Relevance 0.12
Different HLA-DR expression in endometriotic and adenomyotic lesions: correlation with transvaginal ultrasonography findings.
Gene_expression (expression) of HLA-DR associated with endometriosis and dismenorea
7) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Title Doc Link 19585136 Disease Relevance 0.47 Pain Relevance 0.23
CONCLUSION: HLA-DR antigen expression in endometrium and adenomyotic tissues.
Gene_expression (expression) of HLA-DR in endometrium
8) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Body Doc Link 19585136 Disease Relevance 0 Pain Relevance 0
In both groups the HLA-DR expression was significantly higher in the secretory phase than the proliferative or glandular and stroma cells.
Gene_expression (expression) of HLA-DR in stroma
9) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Body Doc Link 19585136 Disease Relevance 0 Pain Relevance 0
We investigated the expression of HLA-DR in endometriotic and adenomyotic tissues within the stromal and glandular cells.
Spec (investigated) Gene_expression (expression) of HLA-DR associated with endometriosis and dismenorea
10) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 19585136 Disease Relevance 0.45 Pain Relevance 0.22
Moreover, we correlate the HLA-DR expression according the transvaginal ultrasonography findings.
Gene_expression (expression) of HLA-DR
11) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 19585136 Disease Relevance 0.44 Pain Relevance 0.22
However, HLA-DR expression is distributed preferentially in glandular epithelial cells in endometrioma and in the adenomyotic stroma.
Gene_expression (expression) of HLA-DR in stroma
12) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Body Doc Link 19585136 Disease Relevance 0 Pain Relevance 0
The significance of de novo expression of HLA-DR antigen by duct cells is discussed.
Gene_expression (expression) of HLA-DR in duct
13) Confidence 0.76 Published 1990 Journal Pancreas Section Abstract Doc Link 1974351 Disease Relevance 0.89 Pain Relevance 0.15
In chronic obstructive pancreatitis, the duct cells strongly expressed the HLA-DR antigen.
Gene_expression (expressed) of HLA-DR in duct associated with pancreatitis
14) Confidence 0.76 Published 1990 Journal Pancreas Section Abstract Doc Link 1974351 Disease Relevance 0.99 Pain Relevance 0.18
Lymphocyte subsets and HLA-DR expression in normal pancreas and chronic pancreatitis.
Gene_expression (expression) of HLA-DR in pancreas associated with chronic pancreatitis
15) Confidence 0.76 Published 1990 Journal Pancreas Section Title Doc Link 1974351 Disease Relevance 0.92 Pain Relevance 0.24
This study was prospectively carried out in order to clarify if an aberrant expression of HLA-DR molecules could take part in the pathogenesis of chronic pancreatitis.
Gene_expression (expression) of HLA-DR associated with chronic pancreatitis
16) Confidence 0.75 Published 1987 Journal Pancreas Section Abstract Doc Link 3498162 Disease Relevance 0.55 Pain Relevance 0.42
Strong HLA-DR expression was observed in 6/12 chronic pancreatitis patients and in 1/9 controls.
Gene_expression (expression) of HLA-DR associated with chronic pancreatitis
17) Confidence 0.75 Published 1987 Journal Pancreas Section Abstract Doc Link 3498162 Disease Relevance 0.67 Pain Relevance 0.51
RESULTS: In adenomyosis tissues, the percentage of HLA-DR cells expression was significantly higher in stromal cells (83.9%) compared to glandular cells (25.8%), (p<0.001).
Gene_expression (expression) of HLA-DR in stromal cells
18) Confidence 0.68 Published 2010 Journal Arch. Gynecol. Obstet. Section Body Doc Link 19585136 Disease Relevance 0 Pain Relevance 0
These results suggest that significant changes in insulin and glucagon production occur in the transplanted pancreas with rejection and that HLA-DR is not expressed by islet cells during graft rejection or with chronic inflammation.
Neg (not) Gene_expression (expressed) of HLA-DR in pancreas associated with inflammation and graft vs host disease
19) Confidence 0.66 Published 1989 Journal Mod. Pathol. Section Abstract Doc Link 2569735 Disease Relevance 0.42 Pain Relevance 0.20
Pancreas transplantation: an immunohistochemical analysis of pancreatic hormones and HLA-DR expression.
Gene_expression (expression) of HLA-DR in Pancreas
20) Confidence 0.66 Published 1989 Journal Mod. Pathol. Section Title Doc Link 2569735 Disease Relevance 0.27 Pain Relevance 0.21

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