INT16364

Context Info Confidence 0.78 First Reported 1987 Last Reported 2010 Negated 11 Speculated 11 Reported most in Abstract Documents 234 Total Number 247 Disease Relevance 118.81 Pain Relevance 45.01

endosome (HLA-DRA) Golgi apparatus (HLA-DRA) endoplasmic reticulum (HLA-DRA) plasma membrane (HLA-DRA) lysosome (HLA-DRA)

Anatomy Link Frequency monocytes 63 T cells 26 CD86 12 epithelial cells 9 macrophages 6 HLA-DRA (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 939 99.84 local anesthetic 49 99.80 Chronic pancreatitis 49 99.66 interstitial cystitis 45 99.64 Dismenorea 22 99.56 rheumatoid arthritis 476 99.34 chemokine 138 99.34 Inflammation 1797 99.28 Enkephalin 183 99.24 substance P 183 98.92

Disease Link Frequency Relevance Heat Adhesions 123 100.00 Endometriosis 55 100.00 Cancer 1035 99.86 Acute Liver Failure 60 99.84 Interstitial Nephritis 32 99.84 Necrosis 257 99.72 Hypersensitivity 137 99.70 Liver Disease 36 99.68 Duodenal Ulcer 10 99.68 Pancreatitis 566 99.66

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RESULTS: Immunohistochemical analysis revealed significantly increased expression of HLA-DR antigen in the glandular cells in eutopic and ectopic endometria, compared with materials from patients with adenomyoma and infertile patients.

Gene_expression (expression) of HLA-DR

1) Confidence 0.78 Published 1993 Journal Fertil. Steril. Section Body Doc Link 8224269 Disease Relevance 0.16 Pain Relevance 0

OBJECTIVE: To evaluate the expression of major histocompatibility complex class II antigen (human leukocyte antigen, HLA-DR) in glandular cells in eutopic and ectopic endometria in patients with endometriosis and adenomyosis.

Gene_expression (expression) of HLA-DR in leukocyte associated with endometriosis and dismenorea

2) Confidence 0.78 Published 1993 Journal Fertil. Steril. Section Abstract Doc Link 8224269 Disease Relevance 0.42 Pain Relevance 0.26

DESIGN: Glandular cells in eutopic and ectopic endometria were analyzed immunohistochemically to localize the expression of HLA-DR antigen.

Gene_expression (expression) of HLA-DR

3) Confidence 0.78 Published 1993 Journal Fertil. Steril. Section Body Doc Link 8224269 Disease Relevance 0.17 Pain Relevance 0

CONCLUSIONS: It is likely that aberrant expression of HLA-DR antigen in glandular cells of eutopic and ectopic endometria in endometriosis and adenomyosis is deeply involved in various immunological abnormalities.

Gene_expression (expression) of HLA-DR

4) Confidence 0.78 Published 1993 Journal Fertil. Steril. Section Body Doc Link 8224269 Disease Relevance 0.14 Pain Relevance 0

Experimental and clinical significance of endotoxin-dependent HLA-DR expression on monocytes.

Gene_expression (expression) of HLA-DR in monocytes

5) Confidence 0.78 Published 1989 Journal J. Surg. Res. Section Title Doc Link 2739399 Disease Relevance 0.06 Pain Relevance 0.10

LPS, added experimentally to whole blood, enhanced HLA-DR expression on monocytes without further manipulation.

Gene_expression (expression) of HLA-DR in monocytes

6) Confidence 0.78 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2739399 Disease Relevance 0.08 Pain Relevance 0.12

Different HLA-DR expression in endometriotic and adenomyotic lesions: correlation with transvaginal ultrasonography findings.

Gene_expression (expression) of HLA-DR associated with endometriosis and dismenorea

7) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Title Doc Link 19585136 Disease Relevance 0.47 Pain Relevance 0.23

CONCLUSION: HLA-DR antigen expression in endometrium and adenomyotic tissues.

Gene_expression (expression) of HLA-DR in endometrium

8) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Body Doc Link 19585136 Disease Relevance 0 Pain Relevance 0

In both groups the HLA-DR expression was significantly higher in the secretory phase than the proliferative or glandular and stroma cells.

Gene_expression (expression) of HLA-DR in stroma

9) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Body Doc Link 19585136 Disease Relevance 0 Pain Relevance 0

We investigated the expression of HLA-DR in endometriotic and adenomyotic tissues within the stromal and glandular cells.

Spec (investigated) Gene_expression (expression) of HLA-DR associated with endometriosis and dismenorea

10) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 19585136 Disease Relevance 0.45 Pain Relevance 0.22

Moreover, we correlate the HLA-DR expression according the transvaginal ultrasonography findings.

Gene_expression (expression) of HLA-DR

11) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 19585136 Disease Relevance 0.44 Pain Relevance 0.22

However, HLA-DR expression is distributed preferentially in glandular epithelial cells in endometrioma and in the adenomyotic stroma.

Gene_expression (expression) of HLA-DR in stroma

12) Confidence 0.78 Published 2010 Journal Arch. Gynecol. Obstet. Section Body Doc Link 19585136 Disease Relevance 0 Pain Relevance 0

The significance of de novo expression of HLA-DR antigen by duct cells is discussed.

Gene_expression (expression) of HLA-DR in duct

13) Confidence 0.76 Published 1990 Journal Pancreas Section Abstract Doc Link 1974351 Disease Relevance 0.89 Pain Relevance 0.15

In chronic obstructive pancreatitis, the duct cells strongly expressed the HLA-DR antigen.

Gene_expression (expressed) of HLA-DR in duct associated with pancreatitis

14) Confidence 0.76 Published 1990 Journal Pancreas Section Abstract Doc Link 1974351 Disease Relevance 0.99 Pain Relevance 0.18

Lymphocyte subsets and HLA-DR expression in normal pancreas and chronic pancreatitis.

Gene_expression (expression) of HLA-DR in pancreas associated with chronic pancreatitis

15) Confidence 0.76 Published 1990 Journal Pancreas Section Title Doc Link 1974351 Disease Relevance 0.92 Pain Relevance 0.24

This study was prospectively carried out in order to clarify if an aberrant expression of HLA-DR molecules could take part in the pathogenesis of chronic pancreatitis.

Gene_expression (expression) of HLA-DR associated with chronic pancreatitis

16) Confidence 0.75 Published 1987 Journal Pancreas Section Abstract Doc Link 3498162 Disease Relevance 0.55 Pain Relevance 0.42

Strong HLA-DR expression was observed in 6/12 chronic pancreatitis patients and in 1/9 controls.

Gene_expression (expression) of HLA-DR associated with chronic pancreatitis

17) Confidence 0.75 Published 1987 Journal Pancreas Section Abstract Doc Link 3498162 Disease Relevance 0.67 Pain Relevance 0.51

RESULTS: In adenomyosis tissues, the percentage of HLA-DR cells expression was significantly higher in stromal cells (83.9%) compared to glandular cells (25.8%), (p<0.001).

Gene_expression (expression) of HLA-DR in stromal cells

18) Confidence 0.68 Published 2010 Journal Arch. Gynecol. Obstet. Section Body Doc Link 19585136 Disease Relevance 0 Pain Relevance 0

These results suggest that significant changes in insulin and glucagon production occur in the transplanted pancreas with rejection and that HLA-DR is not expressed by islet cells during graft rejection or with chronic inflammation.

Neg (not) Gene_expression (expressed) of HLA-DR in pancreas associated with inflammation and graft vs host disease

19) Confidence 0.66 Published 1989 Journal Mod. Pathol. Section Abstract Doc Link 2569735 Disease Relevance 0.42 Pain Relevance 0.20

Pancreas transplantation: an immunohistochemical analysis of pancreatic hormones and HLA-DR expression.

Gene_expression (expression) of HLA-DR in Pancreas

20) Confidence 0.66 Published 1989 Journal Mod. Pathol. Section Title Doc Link 2569735 Disease Relevance 0.27 Pain Relevance 0.21

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