INT16366

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Context Info
Confidence 0.49
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.35
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn3) extracellular region (Edn3)
Anatomy Link Frequency
paw 1
Edn3 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 97.84 Very High Very High Very High
metalloproteinase 22 94.92 High High
antagonist 11 84.04 Quite High
Morphine 1 69.76 Quite High
Visceral pain 1 50.48 Quite High
Pain 2 25.00 Low Low
Antinociceptive 1 25.00 Low Low
Paracetamol 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 10 98.54 Very High Very High Very High
Premature Birth 40 97.36 Very High Very High Very High
Infection 35 96.76 Very High Very High Very High
Pressure And Volume Under Development 4 92.28 High High
Pre-term Labor 13 74.12 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 50.48 Quite High
Reprotox - General 1 1 24.92 Low Low
Increased Venous Pressure Under Development 1 23.60 Low Low
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Rupture 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first phase of nociception (0-5 min after injection) was significantly potentiated by simultaneous injection of either ET-1 (10 or 30 pmol/paw) or ET-3 (10 pmol/paw), but not of the selective ET3 receptor agonist sarafotoxin S6c (SRTX-c; up to 30 pmol/paw).
Gene_expression (injection) of ET-3 in paw associated with nociception and agonist
1) Confidence 0.49 Published 1997 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9276135 Disease Relevance 0.59 Pain Relevance 0.08
Big-ET-1[22-38], big-ET-2[22-37], big-ET-3[22-41] amide and ET-C produced less than 25% effect up to 2000 micrograms/kg.
Gene_expression (produced) of big-ET-3
2) Confidence 0.39 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632332 Disease Relevance 0.20 Pain Relevance 0.04
When injected intraperitoneally into mice, endothelins ET-1, ET-2, ET-3 and big-endothelin-1[1-38] (big-ET-1[1-38]) produced a dose-related, robust and easily quantified abdominal constriction response within 20 min.
Gene_expression (produced) of ET-3
3) Confidence 0.32 Published 1991 Journal Life Sci. Section Abstract Doc Link 1826753 Disease Relevance 0.07 Pain Relevance 0.12
The human endothelin (ET) peptide family is made up of three distinct isoforms—ET-1, ET-2, and ET-3 [55].
Gene_expression (made) of ET-3
4) Confidence 0.06 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.44 Pain Relevance 0.05

General Comments

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