INT163666

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 5.84
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
alveolar macrophages 1
brain 1
epithelial cells 1
skin 1
lungs 1
Cat (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 186 98.04 Very High Very High Very High
Paracetamol 8 96.14 Very High Very High Very High
Hippocampus 12 91.64 High High
Opioid 1 76.44 Quite High
psoriasis 63 75.60 Quite High
agonist 49 74.88 Quite High
Thalamus 2 67.60 Quite High
cerebral cortex 2 67.20 Quite High
Inflammatory response 9 65.36 Quite High
Inflammatory marker 1 62.80 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 133 99.84 Very High Very High Very High
Stress 67 98.50 Very High Very High Very High
INFLAMMATION 193 98.04 Very High Very High Very High
Targeted Disruption 20 95.36 Very High Very High Very High
Injury 13 94.80 High High
Aging 23 93.36 High High
Cancer 51 92.64 High High
Death 16 91.76 High High
Atherosclerosis 25 90.16 High High
Diabetes Mellitus 19 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Catalase was predominantly localized in bronchiolar epithelial cells (Figure 2A) as well as in type II epithelial cells and alveolar macrophages in control lungs.
Localization (localized) of Catalase in alveolar macrophages
1) Confidence 0.80 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.69 Pain Relevance 0.03
Immunohistochemistry was then performed to localize catalase in fibrotic lungs.
Localization (localize) of catalase in lungs associated with fibrosis
2) Confidence 0.80 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.74 Pain Relevance 0.03
Pretreatment with AA (50 and 100mg/kg) orally 2h before the APAP administration attenuated the APAP-induced acute increase in serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activites, replenished the depleted hepatic glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, decreased malondialdehyde (MDA) level and considerably reduced the histopathological alterations in a manner similar to silymarin (Sily).
Localization (decreased) of catalase associated with paracetamol
3) Confidence 0.51 Published 2010 Journal Phytomedicine Section Abstract Doc Link 19836221 Disease Relevance 0.54 Pain Relevance 0.64
Catalase was predominantly localized in bronchiolar epithelial cells (Figure 2A) as well as in type II epithelial cells and alveolar macrophages in control lungs.
Localization (localized) of Catalase in epithelial cells
4) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.69 Pain Relevance 0.03
overexpress human catalase localized to peroxisomes, nuclei, and
Localization (localized) of catalase
5) Confidence 0.26 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559913 Disease Relevance 0.60 Pain Relevance 0
The skin antioxidant system consists of a network of both enzymatic (glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and paraoxonase (PON1)) and nonenzymatic antioxidants.
Localization (network) of catalase in skin
6) Confidence 0.15 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 0.68 Pain Relevance 0.14
Oxidative stress such as lipid peroxidation, protein oxidation and increased activities of catalase, as well as excessive release of glutamic acid and nitric oxide occurred in the whole brain of exposed mice [61].
Localization (release) of catalase in brain associated with stress
7) Confidence 0.06 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC3016300 Disease Relevance 0.23 Pain Relevance 0.18
Antioxidant action is manifested by a decrease of malondialdehyde (MDA) formation via lipid peroxidation and an increase of hepatic antioxidative enzymes and antioxidants such as glutathione peroxidase (GPX), glutathione reductase (GR), catalase (CAT), superoxide dismutase (SOD) and glutathione S transferase (GST).
Localization (transferase) of catalase
8) Confidence 0.05 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.64 Pain Relevance 0.12
catalase, the iron-chelator desferrioxamine or serine protease
Localization (protease) of catalase
9) Confidence 0.05 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.86 Pain Relevance 0.41
In the peroxisomes ATM co-localized with catalase which is involved in the detoxification of reactive oxygen species [18,19].
Localization (localized) of catalase
10) Confidence 0.04 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.17 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox