INT163713

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.40
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tph2) cellular_component (Tph2) response to stress (Tph2)
Anatomy Link Frequency
dorsal horn 1
Tph2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 8 99.68 Very High Very High Very High
spinal dorsal horn 1 99.04 Very High Very High Very High
Pain 6 93.52 High High
Raphe 9 92.76 High High
Serotonin 8 90.56 High High
fluoxetine 3 88.68 High High
Lasting pain 4 88.48 High High
depression 11 87.20 High High
antidepressant 3 86.32 High High
Neurotransmitter 3 80.20 Quite High
Disease Link Frequency Relevance Heat
Pain 9 93.52 High High
Depression 16 87.20 High High
Nervous System Injury 2 80.00 Quite High
Neuropathic Pain 1 78.32 Quite High
Hyperalgesia 2 77.20 Quite High
Shock 1 72.96 Quite High
Neurodegenerative Disease 4 66.40 Quite High
Apoptosis 4 26.60 Quite Low
Manic Depressive Disorder 125 5.00 Very Low Very Low Very Low
Recurrence 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Short-term lithium treatment resulted in a 45% decrease in tph2 mRNA expression and a 31% reduction of TPH2 protein levels, which was completely compensated after long-term treatment.
Negative_regulation (decrease) of TPH2
1) Confidence 0.59 Published 2010 Journal Brain Res. Section Abstract Doc Link 19840776 Disease Relevance 0.06 Pain Relevance 0.36
Compared to negative control shRNA, Tph-2 shRNA induced significantly prolonged downregulation of Tph-2 in the RVM and 5-HT in spinal dorsal horn.
Negative_regulation (downregulation) of Tph-2 in dorsal horn associated with spinal dorsal horn and rostral ventromedial medulla
2) Confidence 0.58 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20573908 Disease Relevance 0.85 Pain Relevance 1.17
Short-term lithium treatment resulted in a 45% decrease in tph2 mRNA expression and a 31% reduction of TPH2 protein levels, which was completely compensated after long-term treatment.
Negative_regulation (reduction) of TPH2
3) Confidence 0.43 Published 2010 Journal Brain Res. Section Abstract Doc Link 19840776 Disease Relevance 0.06 Pain Relevance 0.35
In the same study, the authors reported that short-term lithium treatment (8 days) resulted in a 45% decrease in tryptophan hydroxylase 2 (TPH2) expression and a 31% reduction in TPH2 protein levels, completely compensated after long-term treatment (14 days).
Negative_regulation (reduction) of TPH2
4) Confidence 0.24 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.43 Pain Relevance 0.26

General Comments

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