INT163715

Context Info Confidence 0.30 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.96

COMMD3 (Homo sapiens)

Pain Link Frequency Relevance Heat Buprenorphine 12 100.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The UGT1A1 promoter (TA)(6/7)TAA mutation (UGT1A1*28) resulted in a 28% decrease of BUP glucuronidation V(max) in pooled HLMs but was not statistically associated with glucuronidation rate in 52 individual HLMs.

Neg (not) Positive_regulation (resulted) of Negative_regulation (decrease) of BUP associated with buprenorphine

1) Confidence 0.30 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 19841060 Disease Relevance 0 Pain Relevance 0.96

General Comments

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