INT163747

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.56
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Cav3) plasma membrane organization (Cav3) plasma membrane (Cav3)
enzyme binding (Cav3) protein complex (Cav3) cytoplasm (Cav3)
Anatomy Link Frequency
sensory neurons 1
muscle 1
Cav3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 2 99.86 Very High Very High Very High
analgesia 4 98.86 Very High Very High Very High
nav1.8 2 95.60 Very High Very High Very High
Nav1.7 2 95.16 Very High Very High Very High
Analgesic 4 75.00 Quite High
Calcium channel 4 75.00 Quite High
imagery 6 59.76 Quite High
tolerance 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 99.88 Very High Very High Very High
Hypertrophy 7 81.52 Quite High
Muscle Disease 8 80.48 Quite High
Lipodystrophy 12 79.96 Quite High
Congenital Generalized Lipodystrophy 11 50.00 Quite Low
Syndrome 6 50.00 Quite Low
Arrhythmia Under Development 4 50.00 Quite Low
Volume Depletion And Dehydration 3 43.92 Quite Low
Obesity 11 16.72 Low Low
Cytomegalovirus Infection 1 15.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In muscle, contrary to our results, they found a secondary reduction of caveolin-3 on Western blot.
Negative_regulation (reduction) of caveolin-3 in muscle
1) Confidence 0.54 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2837386 Disease Relevance 0.38 Pain Relevance 0.03
Accordingly, lipoamino acids strongly inhibited native Cav3.2 currents in sensory neurons with small effects on sodium and HVA calcium currents.
Negative_regulation (inhibited) of Cav3 in sensory neurons
2) Confidence 0.42 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19846698 Disease Relevance 0.08 Pain Relevance 0.57
In addition, we demonstrate here that lipoamino acids NAGly and NAGABA-OH produced a strong thermal analgesia and that these effects (but not those of morphine) were abolished in Cav3.2 knock-out mice.
Negative_regulation (abolished) of Cav3 associated with targeted disruption, morphine and analgesia
3) Confidence 0.42 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19846698 Disease Relevance 0.10 Pain Relevance 0.56

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox