INT163755

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.87
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
microglial cells 2
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 22 98.96 Very High Very High Very High
cytokine 70 98.60 Very High Very High Very High
Inflammation 99 97.12 Very High Very High Very High
Cannabinoid receptor 5 95.48 Very High Very High Very High
adenocard 10 83.28 Quite High
Cannabinoid 11 78.48 Quite High
chemokine 1 62.52 Quite High
Inflammatory mediators 4 60.40 Quite High
Multiple sclerosis 10 57.80 Quite High
antagonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 107 97.12 Very High Very High Very High
Apoptosis 22 95.32 Very High Very High Very High
Cancer 24 94.08 High High
Neurodegenerative Disease 28 74.28 Quite High
Disease 62 65.72 Quite High
Targeted Disruption 13 61.60 Quite High
Autoimmune Disease 1 60.12 Quite High
Dementia 4 58.56 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 58.20 Quite High
Multiple Sclerosis 10 57.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even though we do observe slight increases in serine 727 STAT1 phosphorylation with flavonoid treatment alone (Fig. 4 and 5), it is likely that this phenomenon is related to these compounds' pro-apoptotic effects evidenced in tumor cell lines [55,56].
Positive_regulation (increases) of Phosphorylation (phosphorylation) of STAT1 associated with cancer and apoptosis
1) Confidence 0.60 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.40 Pain Relevance 0
IFN-gamma signaling induces phosphorylation of two STAT1 residues: Tyr(701) (Y701), which facilitates dimerization, nuclear translocation, and DNA binding; and Ser(727) (S727), which enables maximal STAT1 transcription activity.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of STAT1
2) Confidence 0.46 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19846878 Disease Relevance 0.08 Pain Relevance 0.23
-induced STAT1 phosphorylation in N9 and murine-derived primary microglial cells
Positive_regulation (induced) of Phosphorylation (phosphorylation) of STAT1 in microglial cells
3) Confidence 0.44 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.18 Pain Relevance 0.13
Interestingly, we observed slight increases in STAT1 phosphorylation at serine 727 with flavonoid treatment alone, which may suggest these compounds have other unrelated, separate mechanisms.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of STAT1
4) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.07 Pain Relevance 0
-induced phosphorylation of JAK/STAT1.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of STAT1
5) Confidence 0.40 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.53 Pain Relevance 0.47
and by the enhanced phosphorylation of STAT1, I?
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of STAT1
6) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.62 Pain Relevance 0.25

General Comments

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