INT163756

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Context Info
Confidence 0.82
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 14.51
Pain Relevance 6.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
microglial cells 8
macrophages 3
nucleus 2
chondrocyte 1
neutrophils 1
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 50 99.48 Very High Very High Very High
Analgesic 5 99.30 Very High Very High Very High
rheumatoid arthritis 75 99.20 Very High Very High Very High
cytokine 350 98.92 Very High Very High Very High
agonist 145 98.64 Very High Very High Very High
Inflammation 657 96.80 Very High Very High Very High
Cannabinoid receptor 30 95.16 Very High Very High Very High
cINOD 76 91.36 High High
Central nervous system 151 84.76 Quite High
antagonist 13 82.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 225 99.90 Very High Very High Very High
Rheumatoid Arthritis 75 99.20 Very High Very High Very High
Cancer 235 98.80 Very High Very High Very High
INFLAMMATION 709 96.80 Very High Very High Very High
Inflammatory Bowel Disease 193 96.72 Very High Very High Very High
Atherosclerosis 33 96.72 Very High Very High Very High
Adhesions 13 96.32 Very High Very High Very High
Obesity 10 94.12 High High
Leukemia 19 93.04 High High
Philadelphia Chromosome 12 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STAT1 is phosphorylated by JAK1/2 kinases at the Tyr701 position and then translocates to the nucleus where it binds to GAS (IFN?
Phosphorylation (phosphorylated) of STAT1 in nucleus
1) Confidence 0.82 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.70 Pain Relevance 0.08
For STAT1 phosphorylation, membranes were probed with a phospho-Ser727 STAT1 antibody or a phospho-Tyr701 STAT1 antibody (Cell Signaling Technology, Danvers, MA) and stripped with stripping solution and then re-probed with antibody that recognize total STAT1 (Cell Signaling Technology).


Phosphorylation (phosphorylation) of STAT1
2) Confidence 0.72 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0 Pain Relevance 0
For instance, apigenin and luteolin appear to regulate serine 727 phosphorylation of STAT1 at levels that are potentially conducive to apoptosis, all the while keeping a damper on levels in the presence of IFN-?
Phosphorylation (phosphorylation) of STAT1 associated with apoptosis
3) Confidence 0.72 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.59 Pain Relevance 0.22
Even though we do observe slight increases in serine 727 STAT1 phosphorylation with flavonoid treatment alone (Fig. 4 and 5), it is likely that this phenomenon is related to these compounds' pro-apoptotic effects evidenced in tumor cell lines [55,56].
Phosphorylation (phosphorylation) of STAT1 associated with cancer and apoptosis
4) Confidence 0.72 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.40 Pain Relevance 0
Densitometric analyis of western blot data from N9 cell lysates in Figure 4B indicate significant reductions in STAT1 phosphorylation at serine residue 727 (p < 0.01) with both apigenin and luteolin treatment.
Phosphorylation (phosphorylation) of STAT1
5) Confidence 0.72 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.12 Pain Relevance 0.09
-induced STAT1 phosphorylation in N9 and murine-derived primary microglial cells
Phosphorylation (phosphorylation) of STAT1 in microglial cells
6) Confidence 0.72 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.18 Pain Relevance 0.13
It has been reported that regulation of apoptosis via STAT1 is dependent upon serine 727 phosphorylation [58-60].
Phosphorylation (phosphorylation) of STAT1 associated with apoptosis
7) Confidence 0.71 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.43 Pain Relevance 0
This is an interesting observation given that macrophages are cells of monocytic lineage, and phosphorylated (p) STAT1 was mainly detected in monocytic cells and neutrophils in the inflamed mucosa of ulcerative colitis patients [27].
Phosphorylation (phosphorylated) of STAT1 in neutrophils associated with inflammatory bowel disease
8) Confidence 0.70 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.28 Pain Relevance 0.04
Results showed that JWH-015 co-treatment significantly inhibited Ser727 phosphorylation of the STAT1 protein at 10 ?
Phosphorylation (phosphorylation) of STAT1
9) Confidence 0.65 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.06 Pain Relevance 0.21
For STAT1 phosphorylation, membranes were probed with a phospho-Ser727 STAT1 antibody (Cell Signaling Technology) and stripped with stripping solution and then re-probed with an antibody that recognizes total STAT1 (Cell Signaling Technology).
Phosphorylation (phosphorylation) of STAT1
10) Confidence 0.65 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.04
-induced phosphorylation of JAK/STAT1.
Phosphorylation (phosphorylation) of STAT1
11) Confidence 0.65 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.53 Pain Relevance 0.47
Unstimulated microglial cells displayed very little detectable JAK1,2 or STAT-1 phosphorylation (data not shown).


Phosphorylation (phosphorylation) of STAT-1 in microglial cells
12) Confidence 0.65 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.07 Pain Relevance 0.21
interaction with its heterodimer type II cytokine receptor, the JAKs are directly activated leading to STAT1 phosphorylation [35,36,38].
Phosphorylation (phosphorylation) of STAT1 associated with cytokine
13) Confidence 0.65 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.22
Accordingly, we examined the effects of CB2 stimulation on STAT1 phosphorylation, in the same dose range mentioned above, on primary microglial cells treated with IFN-?
Phosphorylation (phosphorylation) of STAT1 in microglial cells
14) Confidence 0.65 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.21
This investigation demonstrates that adding adenosine to IFN-gamma-stimulated murine RAW 264.7 and human THP-1 macrophages results in unique modulation of STAT1 serine and tyrosine phosphorylation events.
Phosphorylation (phosphorylation) of STAT1 in macrophages associated with adenocard
15) Confidence 0.62 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19846878 Disease Relevance 0.09 Pain Relevance 0.41
IFN-gamma signaling induces phosphorylation of two STAT1 residues: Tyr(701) (Y701), which facilitates dimerization, nuclear translocation, and DNA binding; and Ser(727) (S727), which enables maximal STAT1 transcription activity.
Phosphorylation (phosphorylation) of STAT1
16) Confidence 0.62 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19846878 Disease Relevance 0.08 Pain Relevance 0.23
Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation.
Phosphorylation (phosphorylation) of STAT1 in macrophage associated with adenocard
17) Confidence 0.62 Published 2009 Journal J. Immunol. Section Title Doc Link 19846878 Disease Relevance 0.08 Pain Relevance 0.48
IFN-gamma signaling induces phosphorylation of two STAT1 residues: Tyr(701) (Y701), which facilitates dimerization, nuclear translocation, and DNA binding; and Ser(727) (S727), which enables maximal STAT1 transcription activity.
Phosphorylation (phosphorylation) of STAT1
18) Confidence 0.62 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19846878 Disease Relevance 0.08 Pain Relevance 0.23
We show that adenosine inhibits IFN-gamma-induced STAT1 S727 phosphorylation by >30% and phosphoserine-mediated transcriptional activity by 58% but has no effect on phosphorylation of Y701 or receptor-associated JAK tyrosine kinases.
Phosphorylation (phosphorylation) of STAT1 associated with adenocard
19) Confidence 0.62 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19846878 Disease Relevance 0.08 Pain Relevance 0.44
Interestingly, we observed slight increases in STAT1 phosphorylation at serine 727 with flavonoid treatment alone, which may suggest these compounds have other unrelated, separate mechanisms.
Phosphorylation (phosphorylation) of STAT1
20) Confidence 0.55 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.07 Pain Relevance 0

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