INT163758

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 5.23
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
lung 5
macrophages 2
neurons 1
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 10 99.80 Very High Very High Very High
Inflammation 121 99.60 Very High Very High Very High
cytokine 92 88.48 High High
antagonist 1 84.20 Quite High
Central nervous system 19 59.72 Quite High
Analgesic 4 57.60 Quite High
withdrawal 3 55.88 Quite High
Nerve growth factor 6 54.68 Quite High
Inflammatory mediators 5 50.76 Quite High
Neuropathic pain 1 50.04 Quite High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 13 100.00 Very High Very High Very High
INFLAMMATION 131 99.60 Very High Very High Very High
Cancer 1093 99.52 Very High Very High Very High
Lymphatic System Cancer 12 99.32 Very High Very High Very High
Apoptosis 257 99.00 Very High Very High Very High
Dislocations 11 95.36 Very High Very High Very High
Dna Damage 110 95.16 Very High Very High Very High
Disease 85 91.24 High High
Targeted Disruption 41 90.52 High High
Disorder Of Lipid Metabolism 2 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even as these compounds affect STAT1, it is more likely that upstream kinases or phosphatases are directly involved.
Regulation (affect) of STAT1
1) Confidence 0.54 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.20 Pain Relevance 0.09
B16F1 co-culture with explanted lung tissue led to a marked (4 to 37 fold) up-regulation of the IFN/STAT1 pathway compared with B16F1/B16F1 mono-culture (Student's two-tailed t-test; p ?
Regulation (regulation) of STAT1 in lung
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0 Pain Relevance 0
Subsequently, cell lines were designated STAT1H if their IFN/STAT1 pathway expression score was?
Regulation (score) of STAT1
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.17 Pain Relevance 0
Our results suggest that a STAT1H status is at least in part responsible for the preexistent ability of B16F1 cells to colonize the lungs.
Regulation (responsible) of STAT1H in lungs
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.22 Pain Relevance 0
The second conclusion is that the lung microenvironment significantly up-regulates the IFN/STAT1 pathway in tumor clones, which may create a selection pressure and provide a survival advantage to the preexisting STAT1H clones that are inherently resistant to this cytotoxic microenvironment.


Regulation (regulates) of STAT1 in lung associated with cancer
5) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.18 Pain Relevance 0
For calculation of the IFN/STAT1 pathway expression score (ES) we used the equation , where Gi?
Regulation (calculation) of STAT1
6) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0 Pain Relevance 0
STAT1 also is involved in anti-angiogenic mechanisms, partially through the induction of IFN?
Regulation (involved) of STAT1
7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.53 Pain Relevance 0
On the contrary, STAT1H cell lines from the P1 panel (Figure 1D) and B16F1 monoclones (Figure 4A) exhibited up-regulation of the IFN/STAT1 pathway only 2 to 3-fold relative to baseline.
Regulation (regulation) of STAT1
8) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.05 Pain Relevance 0
These data indicate that the lung microenvironment uniformly up-regulates the IFN/STAT1 pathway in lung colonies.
Regulation (regulates) of STAT1 in lung
9) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0 Pain Relevance 0
Eight lung colonies profiled in vivo demonstrated up-regulation of the IFN/STAT1 pathway from 60- to 120-fold relative to basal B16F1 in vitro depending on the marker genes (Figure 4B).
Regulation (regulation) of STAT1 in lung
10) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.11 Pain Relevance 0
To test the effects of IFN/STAT1 pathway expression levels on the apoptotic response to Dox we used three STAT1H cell lines (P3m2a, P2m3c, P3m5a) and three STAT1L cell lines (P2m3, P2m6b, and P2m5b).
Regulation (effects) of STAT1 associated with apoptosis
11) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.60 Pain Relevance 0
Additionally, we propose that significant up-regulation of the IFN/STAT1 pathway in vivo likely creates a negative selection pressure against STAT1L clones that are not resistant to the cytotoxic effects of this pathway, thereby selecting for STAT1H clones (Figure 4B).
Regulation (regulation) of STAT1
12) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.22 Pain Relevance 0
These data suggest that A(3) receptor signaling is key to adenosine-mediated STAT1 modulation and anti-inflammatory action in IFN-gamma-activated mouse and human macrophages.
Regulation (modulation) of STAT1 in macrophages associated with adenocard and inflammation
13) Confidence 0.27 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19846878 Disease Relevance 0.24 Pain Relevance 0.50
Indeed, the action of PI3K in these cases appears to be mediated, at least in part, through the regulation of STAT1 serine 727 phosphorylation [11].
Regulation (regulation) of STAT1
14) Confidence 0.24 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.42 Pain Relevance 0.04
It is becoming evident that STAT1 and related signaling proteins may be regulated by flavonoids.
Spec (may) Regulation (regulated) of STAT1
15) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.28 Pain Relevance 0
Importantly, apigenin and luteolin treatment does not appear to affect holoprotein levels of STAT1 (Fig. 4A and 5A).
Spec (appear) Regulation (affect) of STAT1
16) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.11 Pain Relevance 0.03
Additionally, CXCL10, a STAT1 responsive gene [30] was also suppressed by PEO in activated macrophages (Fig 4).
Regulation (responsive) of STAT1 in macrophages
17) Confidence 0.23 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.39 Pain Relevance 0.07
More importantly, we show that the shRNA and miRNA sequences targeting trpV1 have no effect on the expression levels of the closely related trpA1 gene or stat1, which is another gene involved in the INF response, when expressed in neurons in vivo.
Neg (no) Regulation (effect) of stat1 in neurons
18) Confidence 0.23 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 0.29 Pain Relevance 0.11
Therefore, we wanted to study the effects of PEO on activated (phosphorylated at Tyr701) STAT1 (pSTAT1).
Regulation (effects) of pSTAT1
19) Confidence 0.20 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.30 Pain Relevance 0.04
It has been reported that E6 from HPV16 binds to interferon regulatory factor-3 interfering with its activity [57], that could explain why we observed down-regulation of many Interferon-inducible genes such as myxovirus (influenza virus) resistance 1 (Mx1), Oas2 and Stat-1.
Regulation (regulation) of Stat-1 associated with influenza virus infection
20) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.92 Pain Relevance 0

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