INT163776

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.58
Pain Relevance 6.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCH1) small molecule metabolic process (GCH1) nucleolus (GCH1)
nucleus (GCH1) protein complex assembly (GCH1) protein complex (GCH1)
GCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GCH1 111 100.00 Very High Very High Very High
Tetrahydrobiopterin 32 99.98 Very High Very High Very High
Pain 299 99.80 Very High Very High Very High
Serotonin 3 97.90 Very High Very High Very High
Catecholamine 3 97.68 Very High Very High Very High
Lasting pain 9 96.56 Very High Very High Very High
analgesia 26 77.48 Quite High
intrathecal fentanyl 1 77.08 Quite High
opioid receptor 2 74.88 Quite High
IPN 3 65.08 Quite High
Disease Link Frequency Relevance Heat
Pain 297 99.80 Very High Very High Very High
Neuropathic Pain 14 95.28 Very High Very High Very High
Disease 3 80.64 Quite High
Inflammatory Pain 3 65.08 Quite High
Sprains And Strains 1 61.44 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

7 60.00 Quite High
Syndrome 3 58.88 Quite High
Pancreatitis 64 57.20 Quite High
Genetic Predisposition To Disease 2 52.48 Quite High
Abdominal Pain 1 31.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess the effect of variations in GTP cyclohydrolase gene (GCH1) on pain sensitivity in humans.


Regulation (effect) of GCH1 associated with pain and gch1
1) Confidence 0.27 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1821314 Disease Relevance 0.42 Pain Relevance 0.55
To assess the effect of variations in GTP cyclohydrolase gene (GCH1) on pain sensitivity in humans.


Regulation (effect) of GTP cyclohydrolase gene associated with pain and gch1
2) Confidence 0.27 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1821314 Disease Relevance 0.42 Pain Relevance 0.54
BH4, in turn, is an essential cofactor in the synthesis of many pain modulators including catecholamines, serotonin and nitric oxide [12] and feed-forward activation via phenylalanine and feedback inhibition through BH4 regulates the activity of GCH1 [13].
Regulation (regulates) of GCH1 associated with pain, tetrahydrobiopterin, catecholamine, gch1 and serotonin
3) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2912270 Disease Relevance 0.98 Pain Relevance 1.49
Pending independent verification, the results might point to a prophylactic role of decreased GCH1 up-regulation delaying the need for pain therapy.


Regulation (regulation) of GCH1
4) Confidence 0.27 Published 2009 Journal Clin J Pain Section Body Doc Link 19851158 Disease Relevance 0 Pain Relevance 0
Therefore, changes in GCH1 activity would alter BH4 levels and could thereby modulate pain signaling.
Regulation (changes) of GCH1 associated with pain, tetrahydrobiopterin and gch1
5) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2626574 Disease Relevance 1.68 Pain Relevance 2.03
Reducing the elevated BH4 levels associated with pain to baseline, while maintaining sufficient BH4 levels to limit side effects is the goal of discovery programs for novel therapeutics targeting GCH1 or SPR.
Regulation (targeting) of GCH1 associated with pain, tetrahydrobiopterin and gch1
6) Confidence 0.27 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20047156 Disease Relevance 0.49 Pain Relevance 0.75
The rate-limiting enzyme in BH4 synthesis, guanosine triphosphate cyclohydrolase 1 (GCH1), and sepiapterin reductase (SPR) are both promising drug targets based on initial active-site characterization of the SARs of these two enzymes.
Regulation (targets) of GCH1 associated with tetrahydrobiopterin and gch1
7) Confidence 0.27 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20047156 Disease Relevance 0.53 Pain Relevance 0.79

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