INT163777

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.39
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Calb2) cellular_component (Calb2) biological_process (Calb2)
cytoplasm (Calb2)
Anatomy Link Frequency
leydig cell 2
sensory nerve 2
Calb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 8 100.00 Very High Very High Very High
Glutamate 5 100.00 Very High Very High Very High
Neurotransmitter 9 84.56 Quite High
abdominal pain 1 82.84 Quite High
qutenza 8 79.24 Quite High
Calcitonin gene-related peptide 11 76.68 Quite High
substance P 15 76.44 Quite High
nociceptor 9 57.04 Quite High
isoflurane 1 47.68 Quite Low
Somatostatin 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 3 99.02 Very High Very High Very High
Sertoli-leydig Cell Tumor 1 98.64 Very High Very High Very High
Desmoplastic Small Round Cell Tumor 2 98.44 Very High Very High Very High
Cough 72 95.00 High High
Cancer 3 94.96 High High
Leydig Cell Tumor 2 85.08 High High
Abdominal Pain 1 82.84 Quite High
Injury 1 19.20 Low Low
Bronchospasm 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ovarian involvement by desmoplastic small round cell tumor with leydig cell hyperplasia showing an unusual immunophenotype (cytokeratin negative, calretinin and inhibin positive) mimicking poorly differentiated sertoli leydig cell tumor.
Negative_regulation (positive) of Neg (negative) Gene_expression (negative) of calretinin in leydig cell associated with desmoplastic small round cell tumor, sertoli-leydig cell tumor and hyperplasia
1) Confidence 0.34 Published 2009 Journal Int. J. Gynecol. Pathol. Section Title Doc Link 19851210 Disease Relevance 0.93 Pain Relevance 0.08
Immunohistochemical studies of other sensory nerve populations have successfully used the expression of proton pump isozymes, vesicular glutamate transporters (vGluts; a marker for glutamatergic neurons), neuropeptides and calcium binding proteins (such as calretinin, calbindin and parvalbumin) as useful markers for characterizing sensory nerve subtypes.
Negative_regulation (used) of Gene_expression (expression) of calretinin in sensory nerve associated with glutamate and neuropeptide
2) Confidence 0.07 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.45 Pain Relevance 0.50

General Comments

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