INT163780

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 5.10
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Nucb2) endoplasmic reticulum (Nucb2) nucleus (Nucb2)
DNA binding (Nucb2) cytoplasm (Nucb2)
Anatomy Link Frequency
SON 4
pancreas 2
stomach 2
plasma 1
adipocytes 1
Nucb2 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 43 99.88 Very High Very High Very High
Locus ceruleus 14 99.04 Very High Very High Very High
Raphe 4 96.52 Very High Very High Very High
antagonist 10 95.44 Very High Very High Very High
Intracerebroventricular 4 91.68 High High
anesthesia 13 89.64 High High
tolerance 3 85.04 High High
isoflurane 7 81.96 Quite High
conotoxin 4 44.80 Quite Low
qutenza 8 37.28 Quite Low
Disease Link Frequency Relevance Heat
Toxocariasis 8 99.88 Very High Very High Very High
Obesity 100 99.68 Very High Very High Very High
Targeted Disruption 76 98.66 Very High Very High Very High
Insulin Resistance 6 97.88 Very High Very High Very High
Hypertrophy 2 97.60 Very High Very High Very High
Anorexia 14 93.68 High High
Appetite Loss 10 91.60 High High
Diabetes Mellitus 32 83.92 Quite High
Fatty Liver 10 78.32 Quite High
Stress 8 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nesfatin-1, processed from nucleobindin 2, is an anorexigenic peptide expressed in the brain and several peripheral tissues including the stomach and pancreas.
Gene_expression (expressed) of Nesfatin-1 in pancreas
1) Confidence 0.77 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19852938 Disease Relevance 0.07 Pain Relevance 0.05
-MSH markedly stimulates nucleobindin2/nesfatin gene expression in the PVN [145].
Gene_expression (expression) of nesfatin
2) Confidence 0.65 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.19 Pain Relevance 0.05
Nesfatin-1, processed from nucleobindin 2, is an anorexigenic peptide expressed in the brain and several peripheral tissues including the stomach and pancreas.
Gene_expression (expressed) of nucleobindin 2 in pancreas
3) Confidence 0.58 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19852938 Disease Relevance 0.07 Pain Relevance 0.05
Double Fos/nesfatin-1 labeling showed that of the activated cells, 99% were nesfatin-1-immunoreactive in the SON, 91% in the LC, 82% in the rRPa, 74% in the EW and VLM, 71% in the anterior parvicellular PVN, 47% in the lateral magnocellular PVN, 41% in the medial magnocellular PVN, 14% in the NTS and 9% in the medial parvicellular PVN.
Gene_expression (Double) of nesfatin-1 in SON associated with medulla and locus ceruleus
4) Confidence 0.30 Published 2010 Journal Peptides Section Abstract Doc Link 19944727 Disease Relevance 0.33 Pain Relevance 0.67
Double Fos/nesfatin-1 labeling showed that of the activated cells, 99% were nesfatin-1-immunoreactive in the SON, 91% in the LC, 82% in the rRPa, 74% in the EW and VLM, 71% in the anterior parvicellular PVN, 47% in the lateral magnocellular PVN, 41% in the medial magnocellular PVN, 14% in the NTS and 9% in the medial parvicellular PVN.
Gene_expression (immunoreactive) of nesfatin-1 in SON associated with medulla and locus ceruleus
5) Confidence 0.30 Published 2010 Journal Peptides Section Abstract Doc Link 19944727 Disease Relevance 0.33 Pain Relevance 0.67
Double Fos/nesfatin-1 labeling showed that of the activated cells, 99% were nesfatin-1-immunoreactive in the SON, 91% in the LC, 82% in the rRPa, 74% in the EW and VLM, 71% in the anterior parvicellular PVN, 47% in the lateral magnocellular PVN, 41% in the medial magnocellular PVN, 14% in the NTS and 9% in the medial parvicellular PVN.
Gene_expression (/) of nesfatin-1 in SON associated with medulla and locus ceruleus
6) Confidence 0.30 Published 2010 Journal Peptides Section Abstract Doc Link 19944727 Disease Relevance 0.32 Pain Relevance 0.66
Double Fos/nesfatin-1 labeling showed that of the activated cells, 99% were nesfatin-1-immunoreactive in the SON, 91% in the LC, 82% in the rRPa, 74% in the EW and VLM, 71% in the anterior parvicellular PVN, 47% in the lateral magnocellular PVN, 41% in the medial magnocellular PVN, 14% in the NTS and 9% in the medial parvicellular PVN.
Gene_expression (labeling) of nesfatin-1 in SON associated with medulla and locus ceruleus
7) Confidence 0.30 Published 2010 Journal Peptides Section Abstract Doc Link 19944727 Disease Relevance 0.32 Pain Relevance 0.67
Nesfatin-1, processed from nucleobindin 2, is an anorexigenic peptide expressed in the brain and several peripheral tissues including the stomach and pancreas.
Gene_expression (expressed) of Nesfatin-1 in stomach
8) Confidence 0.26 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19852938 Disease Relevance 0.07 Pain Relevance 0.05
Nesfatin-1, processed from nucleobindin 2, is an anorexigenic peptide expressed in the brain and several peripheral tissues including the stomach and pancreas.
Gene_expression (expressed) of nucleobindin 2 in stomach
9) Confidence 0.20 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19852938 Disease Relevance 0.07 Pain Relevance 0.05
Figure 1a shows plasma NEFA levels in the three groups of mice.
Gene_expression (levels) of NEFA in plasma
10) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 0.93 Pain Relevance 0.04
In contrast, fasting Fgf21 knockout mice showed increased lipolysis in adipocytes and increased serum NEFA levels.
Gene_expression (levels) of NEFA in adipocytes associated with targeted disruption and obesity
11) Confidence 0.10 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.20 Pain Relevance 0
Serum NEFA levels were significantly decreased, although serum glucose and triglyceride levels were essentially unchanged.
Gene_expression (levels) of NEFA
12) Confidence 0.10 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.20 Pain Relevance 0

General Comments

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