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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
skin 1
Casp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 95.64 Very High Very High Very High
cytokine 4 91.48 High High
allodynia 3 88.44 High High
substance P 3 84.56 Quite High
reflex sympathetic dystrophy 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 3 88.44 High High
Nociception 5 81.28 Quite High
Complex Regional Pain Syndromes 4 75.00 Quite High
Bone Fracture 1 63.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using this model we observed that: (1) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, (2) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1, and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, (3) LY303870, an NK1 receptor antagonist, effectively blocked fracture-induced up-regulation of activated inflammasome components and cytokines, (4) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and (5) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture-induced hindpaw mechanical allodynia.
Transcription (number) of caspase-1 in skin associated with allodynia, antagonist and cytokine
1) Confidence 0.58 Published 2009 Journal Pain Section Abstract Doc Link 19853379 Disease Relevance 0.88 Pain Relevance 0.73

General Comments

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