INT163794

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.40
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CYSLTR1) signal transducer activity (CYSLTR1)
Anatomy Link Frequency
plasma 1
face 1
CYSLTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 4 100.00 Very High Very High Very High
Inflammation 20 98.64 Very High Very High Very High
Pain 4 98.36 Very High Very High Very High
antagonist 25 97.76 Very High Very High Very High
Potency 3 90.52 High High
agonist 15 89.76 High High
aspirin 78 87.96 High High
cINOD 2 68.84 Quite High
cytokine 2 11.04 Low Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 4 100.00 Very High Very High Very High
INFLAMMATION 22 98.64 Very High Very High Very High
Asthma 63 98.48 Very High Very High Very High
Anaphylactic Hypersensitivity 1 97.28 Very High Very High Very High
Hypersensitivity 12 96.48 Very High Very High Very High
Li-fraumeni Syndrome 1 94.52 High High
Occupational Lung Diseases 4 85.16 High High
Pain 4 75.00 Quite High
Cancer 43 53.92 Quite High
Atherosclerosis 23 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the classic view that the activity of cysteinyl-LTs is due to the interaction with these two specific plasma membrane receptors, alternative pathways have been postulated, including localization of CysLT receptors at nuclear level, cross talk with other membrane receptors, the possibility that CysLT receptors might exist as homo/heterodimers, and the existence of additional receptor subtypes [22].
Localization (localization) of CysLT in plasma
1) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817543 Disease Relevance 0.07 Pain Relevance 0.13
CysLTs exert their biological actions by binding to two types of G protein-coupled receptors, i.e., cysteinyl leukotriene receptor 1 (CYSLTR1), which is sensitive to the asthma drugs montelukast (MLK), zafirlukast, and pranlukast,8,9 and CYSLTR2.10
Localization (i.e.) of cysteinyl leukotriene receptor 1 associated with asthma
2) Confidence 0.19 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2831603 Disease Relevance 1.20 Pain Relevance 0.41
The study addresses spatial organization of LTD within one side of the face.
Localization (organization) of LTD in face associated with depression
3) Confidence 0.08 Published 2009 Journal Clin Neurophysiol Section Abstract Doc Link 19853504 Disease Relevance 0.54 Pain Relevance 0.36
LTC4, LTD4, and LTE4) have been implicated as
Localization (implicated) of LTD4
4) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.59 Pain Relevance 0.18

General Comments

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