INT1638

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2011
Negated 3
Speculated 3
Reported most in Abstract
Documents 92
Total Number 99
Disease Relevance 21.69
Pain Relevance 26.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
Anatomy Link Frequency
plasma 16
pituitary 5
ovaries 3
follicle 2
arms 2
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 197 100.00 Very High Very High Very High
withdrawal 78 100.00 Very High Very High Very High
Morphine 11 99.98 Very High Very High Very High
antagonist 466 99.96 Very High Very High Very High
depression 65 99.90 Very High Very High Very High
agonist 489 99.80 Very High Very High Very High
Dopamine 8 99.76 Very High Very High Very High
cytokine 27 99.62 Very High Very High Very High
Endogenous opioid 54 99.60 Very High Very High Very High
opiate 58 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 18 99.98 Very High Very High Very High
Depression 90 99.90 Very High Very High Very High
Disease 190 99.76 Very High Very High Very High
Polycystic Ovary Syndrome 238 99.24 Very High Very High Very High
Cancer 132 99.14 Very High Very High Very High
Rheumatoid Arthritis 15 99.12 Very High Very High Very High
Opiate Addiction 10 99.00 Very High Very High Very High
Body Weight 23 98.96 Very High Very High Very High
Endometriosis (extended) 346 98.64 Very High Very High Very High
Stress 138 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic administration of veralipride resulted in a significant (P less than 0.01) decline in plasma LH levels.
Negative_regulation (decline) of LH in plasma
1) Confidence 0.59 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2834413 Disease Relevance 0 Pain Relevance 0.40
Acute doses of heroin (10 mg i.v.) significantly suppressed LH levels.
Negative_regulation (suppressed) of LH
2) Confidence 0.59 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400959 Disease Relevance 0.29 Pain Relevance 0.35
The mean plasma LH concentration was 7.9 +/- 0.5 IU/L during the saline control study and was decreased to 6.9 +/- 0.6 IU/L by the infusion of T (P < 0.05).
Negative_regulation (decreased) of LH in plasma
3) Confidence 0.58 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1430081 Disease Relevance 0 Pain Relevance 0.22
The injection of morphine decreases plasma LH levels, abolishing the pulsatile pattern of secretion.
Negative_regulation (decreases) of LH in plasma associated with morphine
4) Confidence 0.57 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2689783 Disease Relevance 0.15 Pain Relevance 0.54
Pretreatment with the opioid receptor antagonist naloxone, blocked the decrease of plasma LH levels.
Negative_regulation (decrease) of LH in plasma associated with antagonist, narcan and opioid receptor
5) Confidence 0.55 Published 1985 Journal Peptides Section Abstract Doc Link 3936026 Disease Relevance 0 Pain Relevance 0.29
In fertile subjects, dermorphin (5.5 micrograms/kg min for 30 min) decreases plasma LH (p less than 0.01 vs. baseline and placebo values), but not plasma FSH.
Negative_regulation (decreases) of LH in plasma
6) Confidence 0.55 Published 1985 Journal Peptides Section Abstract Doc Link 3936026 Disease Relevance 0 Pain Relevance 0.21
LH levels declined to 62% of the levels observed in the pretreatment control period (P < 0.05).
Negative_regulation (declined) of LH
7) Confidence 0.55 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8388404 Disease Relevance 0.51 Pain Relevance 0.50
During a subsequent 10-day period of buprenorphine maintenance at a dose of a 8 mg s.c., LH levels remained suppressed and prolactin levels continued to be elevated.
Negative_regulation (suppressed) of LH associated with buprenorphine
8) Confidence 0.54 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7057390 Disease Relevance 0 Pain Relevance 1.05
Buprenorphine, a mixed opiate agonist-antagonist, suppressed plasma luteinizing hormone (LH) and increased prolactin levels after 12 consecutive days of ascending dose administration (0.5-8 mg/day s.c.) in comparison to drug-free control conditions.
Negative_regulation (suppressed) of LH in plasma associated with antagonist, agonist, opiate and buprenorphine
9) Confidence 0.54 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7057390 Disease Relevance 0 Pain Relevance 0.76
Endotoxin could alter circulating concentrations of LH via actions at the hypothalamus through altered GnRH production and/or release, or endotoxin could alter circulating concentrations of LH at the level of the pituitary via inhibition of LH production and release or inhibition of LH in response to GnRH.
Negative_regulation (inhibition) of LH in pituitary
10) Confidence 0.54 Published 2003 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 12963096 Disease Relevance 0.08 Pain Relevance 0.15
In group III, the single high dose of 1200 mg VPA significantly suppressed serum LH levels.
Negative_regulation (suppressed) of LH
11) Confidence 0.50 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8675571 Disease Relevance 0 Pain Relevance 0.27
On the contrary, its administration to postmenopausal subjects treated with conjugated estrogens and medroxyprogesterone acetate significantly decreased plasma LH levels (p less than 0.01, vs. baseline, placebo and area under the curve).
Negative_regulation (decreased) of LH in plasma
12) Confidence 0.48 Published 1985 Journal Peptides Section Abstract Doc Link 3936026 Disease Relevance 0 Pain Relevance 0.28
However, DAMME significantly reduced plasma LH levels in normal, in castrated, and in clomiphene-treated normal subjects.
Negative_regulation (reduced) of LH in plasma
13) Confidence 0.46 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6317469 Disease Relevance 0 Pain Relevance 0.52
The repeated administration of GnRH restored the hyporesponsiveness of serum FSH and increased serum testosterone level from less than 1.0 to 1.7 nmol/l, but the impaired LH response to the standard GnRH test was not improved.
Negative_regulation (impaired) of LH
14) Confidence 0.44 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3101337 Disease Relevance 0.15 Pain Relevance 0.13
Morphine significantly decreased plasma LH levels in all groups examined (P less than 0.01).
Negative_regulation (decreased) of LH in plasma associated with morphine
15) Confidence 0.43 Published 1986 Journal Life Sci. Section Abstract Doc Link 3086650 Disease Relevance 0.21 Pain Relevance 0.86
LH levels after chronic heroin use were lower than control levels but the degree of LH suppression was approximately the same as after the acute doses of heroin.
Negative_regulation (suppression) of LH associated with opiate addiction
16) Confidence 0.43 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400959 Disease Relevance 0.28 Pain Relevance 0.38
Endogenous opioid peptides tonically inhibit LH by acting on hypothalamic mechanisms which regulate LHRH secretion.
Negative_regulation (inhibit) of LH associated with endogenous opioid
17) Confidence 0.43 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 3621624 Disease Relevance 0 Pain Relevance 0.50
Chronic stress leads to suppression of the hypothalamic-pituitary-gonadal (HPG) axis with decreased plasma LH concentrations.
Negative_regulation (decreased) of LH in plasma associated with stress
18) Confidence 0.43 Published 1997 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9024279 Disease Relevance 0.10 Pain Relevance 0.16
Both bio and immunoactive LH levels began to decline at 45-60 min, but in most subjects remained significantly elevated by about 30% above the basal values at 120 min.
Negative_regulation (decline) of LH
19) Confidence 0.42 Published 1985 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3914504 Disease Relevance 0 Pain Relevance 0.10
When 1200 mg of VPA was administered before naloxone infusion, the level of LH suppression was 18% and was associated with a significant decrease in LH pulse frequency (P < 0.01).
Negative_regulation (suppression) of LH associated with narcan
20) Confidence 0.42 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8675571 Disease Relevance 0 Pain Relevance 0.36

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