INT163803

Context Info Confidence 0.61 First Reported 2010 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.51 Pain Relevance 0.33

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat) Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)

Cat (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 56 86.28 potassium channel 1 83.16 qutenza 4 79.36 Inflammation 42 69.76 Spinal cord 2 30.96 cytokine 8 5.00 metalloproteinase 6 5.00 chemokine 3 5.00 anesthesia 2 5.00 cerebral cortex 1 5.00

Disease Link Frequency Relevance Heat Stress 62 99.80 Metaplasia 3 97.92 Pulmonary Fibrosis 29 86.28 Motor Neuron Diseases 16 81.40 Disease 19 80.28 Apoptosis 36 76.88 Lifespan 12 76.36 Disease Progression 11 72.00 INFLAMMATION 39 69.76 Fibrosis 44 49.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We then examined the dynamic change in bronchiolar catalase expression following administration of bleomycin in mice.

Spec (examined) Regulation (change) of Gene_expression (expression) of catalase

1) Confidence 0.61 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.24 Pain Relevance 0.07

Furthermore, we hypothesized that CR would: (a) increase antixodant enzymes (MnSOD and Cu/Zn-SOD) and UCP3 as a compensatory mechanism to counteract the increase in oxidative stress, (b) not affect catalase activity since this enzyme is resistant to changes in dietaty intake, (c) increase TNF-?

Neg (not) Regulation (affect) of Neg (not) Gene_expression (activity) of catalase associated with stress

2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.19 Pain Relevance 0.07

AAs afforded a dose-related gastroprotection against the ethanol damage and further prevented the ethanol-induced changes in the levels of GSH, MDA, catalase, SOD and nitrate/nitrite.

Regulation (changes) of Gene_expression (levels) of catalase

3) Confidence 0.11 Published 2010 Journal Chem. Biol. Interact. Section Abstract Doc Link 19853593 Disease Relevance 0.09 Pain Relevance 0.19

General Comments

This test has worked.