INT163803

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.51
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Cat (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 56 86.28 High High
potassium channel 1 83.16 Quite High
qutenza 4 79.36 Quite High
Inflammation 42 69.76 Quite High
Spinal cord 2 30.96 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 62 99.80 Very High Very High Very High
Metaplasia 3 97.92 Very High Very High Very High
Pulmonary Fibrosis 29 86.28 High High
Motor Neuron Diseases 16 81.40 Quite High
Disease 19 80.28 Quite High
Apoptosis 36 76.88 Quite High
Lifespan 12 76.36 Quite High
Disease Progression 11 72.00 Quite High
INFLAMMATION 39 69.76 Quite High
Fibrosis 44 49.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then examined the dynamic change in bronchiolar catalase expression following administration of bleomycin in mice.
Spec (examined) Regulation (change) of Gene_expression (expression) of catalase
1) Confidence 0.61 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.24 Pain Relevance 0.07
Furthermore, we hypothesized that CR would: (a) increase antixodant enzymes (MnSOD and Cu/Zn-SOD) and UCP3 as a compensatory mechanism to counteract the increase in oxidative stress, (b) not affect catalase activity since this enzyme is resistant to changes in dietaty intake, (c) increase TNF-?
Neg (not) Regulation (affect) of Neg (not) Gene_expression (activity) of catalase associated with stress
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.19 Pain Relevance 0.07
AAs afforded a dose-related gastroprotection against the ethanol damage and further prevented the ethanol-induced changes in the levels of GSH, MDA, catalase, SOD and nitrate/nitrite.
Regulation (changes) of Gene_expression (levels) of catalase
3) Confidence 0.11 Published 2010 Journal Chem. Biol. Interact. Section Abstract Doc Link 19853593 Disease Relevance 0.09 Pain Relevance 0.19

General Comments

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