INT163809

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.70
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
microglia 2
Cd6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 65 98.18 Very High Very High Very High
tolerance 24 95.00 High High
Opioid 21 94.60 High High
excitatory amino acid 1 86.96 High High
Glutamate 1 81.60 Quite High
Pain 8 78.80 Quite High
antagonist 10 76.92 Quite High
antinociception 7 70.80 Quite High
Endogenous opioid 1 67.48 Quite High
intrathecal 8 52.08 Quite High
Disease Link Frequency Relevance Heat
Hypertrophy 4 99.50 Very High Very High Very High
Gliosis 12 98.82 Very High Very High Very High
Nociception 10 92.16 High High
Pain 10 78.80 Quite High
Neuropathic Pain 5 67.40 Quite High
Lumbar Puncture Related Headaches 4 27.64 Quite Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Non-diabetic Peripheral Neuropathy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OX42 expression level at days 1, 3 and 7, and GFAP expression level at days 3, 7 and 14 were higher in ETM (P<0.05), but not in 30mg/kg METM, than in CON group.
Positive_regulation (higher) of Gene_expression (expression) of OX42
1) Confidence 0.01 Published 2009 Journal Arch. Oral Biol. Section Body Doc Link 19853838 Disease Relevance 0.07 Pain Relevance 0
Chronic, but not acute, morphine administration, induces gliosis characterized by cell hypertrophy, and is associated with increased expression of GFAP [19,27-30] in astrocytes and CD3/CD11B (OX42) in microglia [31].
Positive_regulation (increased) of Gene_expression (expression) of OX42 in microglia associated with hypertrophy, gliosis and morphine
2) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2862024 Disease Relevance 0.63 Pain Relevance 0.92

General Comments

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