INT16382

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Context Info
Confidence 0.04
First Reported 1991
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Grin1, Gnmt) cytosol (Gnmt) nucleus (Gnmt)
plasma membrane (Grin1) enzyme binding (Grin1)
Anatomy Link Frequency
dorsal horn 1
Grin1 (Rattus norvegicus)
Gnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 3 100.00 Very High Very High Very High
antagonist 2 99.62 Very High Very High Very High
Dorsal horn 1 97.28 Very High Very High Very High
c fibre 1 92.40 High High
anesthesia 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 3 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of 7-chlorokynurenate (7CK), an antagonist at the allosteric glycine site associated with the N-methyl-D-aspartate receptor, applied intrathecally, were tested on nociceptive neurones in the dorsal horn of the anaesthetized rat. 7CK reduced the frequency dependent potentiation (wind-up) of the cells to repeated C-fibre stimulation and the related post-discharges at doses which had minimal effects on the C and A-fibre inputs onto the cells although these were reduced by higher doses of the antagonist.
N-methyl-D-aspartate receptor Binding (associated) of glycine site in dorsal horn associated with nociception, c fibre, nmda receptor, antagonist and dorsal horn
1) Confidence 0.04 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1826945 Disease Relevance 0.17 Pain Relevance 0.32

General Comments

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