INT163828

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 5.20
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Anatomy Link Frequency
cleavage 1
nucleus 1
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 7 97.92 Very High Very High Very High
Inflammation 2 71.16 Quite High
cINOD 6 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 300 99.24 Very High Very High Very High
Breast Cancer 8 96.48 Very High Very High Very High
Mantle-cell Lymphoma 33 94.00 High High
Transitional Cell Carcinoma 4 92.88 High High
Apoptosis 65 92.60 High High
Urinary Tract Cancer 1 88.16 High High
Carcinoma 35 86.40 High High
Glioma 156 86.00 High High
Renal Cell Carcinoma 13 80.20 Quite High
Hyperplasia 15 79.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have noted that cytoplasmic localization of p27 lead to an inactivation of its normal function as negative cell cycle regulator [34].
Localization (localization) of p27
1) Confidence 0.66 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.34 Pain Relevance 0.04
Western blot analysis revealed that p27Kip1 expression increased with the treatments while its phosphorylation at Ser10 and Thr187 decreased, thereby indicating the nuclear localization of increased p27Kip1 protein.
Localization (localization) of p27Kip1
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.32 Pain Relevance 0
We further investigated the influence of these treatments on p27Kip1 expression and localization.
Localization (localization) of p27Kip1
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.40 Pain Relevance 0
This was further confirmed by the immunofluorescence analysis where the treatment showed nuclear presence of p27Kip1.
Localization (presence) of p27Kip1
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.26 Pain Relevance 0
Western blot analysis revealed that p27Kip1 expression increased with the treatments while its phosphorylation at Ser10 and Thr187 decreased, thereby indicating the nuclear localization of increased p27Kip1 protein.
Localization (localization) of p27Kip1
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.32 Pain Relevance 0
Immunoflourescence staining assay revealed that the treatments induced an increase in p27Kip1 localization in the nucleus when compared with control cells (Fig. 2C) and a higher number of cells expressing p27Kip1 in the nuclei was observed with the pCU treatment (Fig.
Localization (localization) of p27Kip1 in nucleus
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.06 Pain Relevance 0
Cytoplasmic translocation of p27Kip1 has been increasingly recognized in primary human tumors associated with poor survival whereas nuclear expression confers a more favorable outcome [12].
Localization (translocation) of p27Kip1 associated with cancer
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 1.04 Pain Relevance 0
In contrast, cell-cycle regulator p27(KIP1), caspase activity as well as poly-ADP ribose polymerase (PARP) cleavage were increased.
Localization (cleavage) of p27 in cleavage
8) Confidence 0.19 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.89 Pain Relevance 0.45
These effects are mediated by nuclear accumulation of the p27(Kip1) inhibitor induced by the downregulation of the p45(Skp2) and Cks1 proteins, which target p27(Kip1) for degradation.
Localization (accumulation) of p27
9) Confidence 0.09 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.56 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox