INT163831

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ERBB2, CCND1) nucleus (ERBB2, CCND1) nucleoplasm (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell proliferation (ERBB2)
Anatomy Link Frequency
BT-474 1
ERBB2 (Homo sapiens)
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 7 88.56 High High
Disease Link Frequency Relevance Heat
Apoptosis 2 98.36 Very High Very High Very High
Breast Cancer 7 96.42 Very High Very High Very High
Cancer 3 83.56 Quite High
Toxicity 1 47.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The drug potently inhibited growth of ER-positive (MCF-7, T47D, BT-474) and ER-negative (SKBR-3, MDA-MB231) breast cancer cell lines, which was associated with G(0)/G(1) cell-cycle arrest, increased levels of apoptosis and reduced protein expression of human epidermal growth factor receptor (EGFR), HER-2, activated extracellular-regulated kinase (ERK) and cyclin D1.
HER-2 Positive_regulation (activated) of cyclin D1 in BT-474 associated with breast cancer and apoptosis
1) Confidence 0.03 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.82 Pain Relevance 0.38

General Comments

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