INT163832

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 50
Total Number 52
Disease Relevance 39.71
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
BT-474 4
osteoblast 2
colon 2
skin 2
apoptotic cell 2
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 409 98.88 Very High Very High Very High
agonist 44 97.20 Very High Very High Very High
Cannabinoid 27 95.48 Very High Very High Very High
Endocannabinoid 27 93.44 High High
palliative 13 89.52 High High
qutenza 14 89.24 High High
Central nervous system 46 89.20 High High
positron emission tomography 10 79.60 Quite High
Pain 17 79.04 Quite High
imagery 34 76.36 Quite High
Disease Link Frequency Relevance Heat
Non-small-cell Lung Cancer 148 100.00 Very High Very High Very High
Apoptosis 755 99.90 Very High Very High Very High
Cancer 1542 99.72 Very High Very High Very High
Acute Coronary Syndrome 49 99.64 Very High Very High Very High
Colon Cancer 405 99.60 Very High Very High Very High
Carcinoma 59 99.54 Very High Very High Very High
Pulmonary Disease 63 99.52 Very High Very High Very High
Disease 385 99.40 Very High Very High Very High
Adenoma 120 99.40 Very High Very High Very High
Inflammatory Breast Neoplasms 137 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, our results suggest that these smoking cessation-induced epithelial changes in COPD are not accompanied by reduced EGFR expression.
Negative_regulation (reduced) of Gene_expression (expression) of EGFR associated with pulmonary disease and nicotine addiction
1) Confidence 0.59 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 2.17 Pain Relevance 0
Total EGFR expression and EGF-induced phosphorylation of ERK1/2 proteins was also downregulated following pretreatment with sulindac sulfide (Figure 3).
Negative_regulation (downregulated) of Gene_expression (expression) of EGFR
2) Confidence 0.57 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.38 Pain Relevance 0
In this study, combination modality of PDT and Erbitux was effective in reducing the expression of EGFR and that could have lead to the regression of tumors in this group.
Negative_regulation (reducing) of Gene_expression (expression) of EGFR associated with cancer
3) Confidence 0.57 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 1.27 Pain Relevance 0
EGFR expression analyzed using immunoblotting was found to be lower in the PDT plus Erbitux group (p < 0.001) compared to control, PDT only and Erbitux only groups (Figure 2).
Negative_regulation (lower) of Spec (analyzed) Gene_expression (expression) of EGFR
4) Confidence 0.57 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 1.46 Pain Relevance 0
IHC and IF results showed similar trends in which the combination of PDT and Erbitux resulted in significant reduction of EGFR expression at 4-6% (EGFR score 1) compared to monotherapy and control groups.
Negative_regulation (reduction) of Gene_expression (expression) of EGFR
5) Confidence 0.57 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 1.45 Pain Relevance 0
Sulindac metabolites decreased expression of both total and pEGFR proteins.
Negative_regulation (decreased) of Gene_expression (expression) of pEGFR
6) Confidence 0.50 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.23 Pain Relevance 0.08
The etiology underlying the sparing of the previously irradiated skin maybe due to either decrease in the population of EGFR expressing cells or decrease in the EGFR expression.
Negative_regulation (decrease) of Gene_expression (expression) of EGFR in skin
7) Confidence 0.43 Published 2010 Journal Radiat Oncol Section Abstract Doc Link PMC2893190 Disease Relevance 0.49 Pain Relevance 0
Immunohistochemical studies demonstrated different degrees of EGFR expression in several salivary gland carcinomas, including MECs and adenoid cystic carcinomas (ACCs).
Negative_regulation (degrees) of Gene_expression (expression) of EGFR in salivary gland associated with adenoid cystic carcinoma and carcinoma
8) Confidence 0.43 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2570365 Disease Relevance 0.80 Pain Relevance 0.19
Detection of EGFR expression and specific mutations within the gene allow for selection of patients most likely to benefit from the drug.
Negative_regulation (Detection) of Gene_expression (expression) of EGFR
9) Confidence 0.43 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 1.05 Pain Relevance 0.07
The degree of EGFR expression can be evaluated by immunohistochemistry (IHC) and the EGFR gene copy number by fluorescent in situ hybridization (FISH).
Negative_regulation (degree) of Gene_expression (expression) of EGFR
10) Confidence 0.43 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 1.21 Pain Relevance 0.05
EGFR is a member of the EGFR/ErbB/HER family
Negative_regulation (/) of Gene_expression (family) of EGFR
11) Confidence 0.42 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.40 Pain Relevance 0
Furthermore, in all three cell lines, anandamide treatment reduced the expression of EGFR, again in a manner blocked by rimonabant [5].
Negative_regulation (reduced) of Gene_expression (expression) of EGFR
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009725 Disease Relevance 1.10 Pain Relevance 0.18
In this exploratory, retrospective study, genotype, allele frequencies and stratified analysis of EGFR were compared between ACS cases and controls using the ?
Negative_regulation (compared) of Gene_expression (analysis) of EGFR associated with acute coronary syndrome
13) Confidence 0.42 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2515827 Disease Relevance 0.19 Pain Relevance 0
Sulindac metabolites downregulate basal EGFR phosphorylation and expression
Negative_regulation (downregulate) of Gene_expression (expression) of EGFR
14) Confidence 0.42 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.34 Pain Relevance 0
We report, for the first time, that sulindac metabolites block both basal and EGF induced phosphorylation of EGFR and downregulate total EGFR protein expression.
Negative_regulation (downregulate) of Gene_expression (expression) of EGFR protein
15) Confidence 0.42 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.29 Pain Relevance 0.35
These results suggest that downregulation of EGFR signaling by sulindac metabolites may occur, at least in part, by inhibiting activation and expression of EGFR.
Negative_regulation (inhibiting) of Gene_expression (expression) of EGFR
16) Confidence 0.42 Published 2005 Journal J Carcinog Section Abstract Doc Link PMC1208922 Disease Relevance 0.25 Pain Relevance 0
Pretreatment with sulindac metabolites for 24 h blocked EGF-induced phosphorylation of both EGFR and ERK1/2 and decreased total EGFR protein expression.
Negative_regulation (decreased) of Gene_expression (expression) of EGFR protein
17) Confidence 0.42 Published 2005 Journal J Carcinog Section Abstract Doc Link PMC1208922 Disease Relevance 0.64 Pain Relevance 0.22
Although the downregulation of EGFR observed with sulindac metabolites occurred prior to either biochemical or morphologic evidence of apoptosis, it remains possible that some of the decrease in EGFR protein expression could be a consequence of caspase activation by sulindac metabolites.
Negative_regulation (decrease) of Gene_expression (expression) of EGFR protein associated with apoptosis
18) Confidence 0.42 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.33 Pain Relevance 0
The goal of this study was to specifically test the hypothesis that sulindac metabolites block activation and/or expression of EGFR (Figure 1).
Negative_regulation (block) of Gene_expression (expression) of EGFR
19) Confidence 0.42 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.32 Pain Relevance 0.42
We now report, for the first time, that sulindac metabolites inhibit EGFR phosphorylation and downregulate the expression of total EGFR protein in human colon cancer cells.
Negative_regulation (downregulate) of Gene_expression (expression) of EGFR protein in colon associated with colon cancer
20) Confidence 0.42 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.68 Pain Relevance 0

General Comments

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