INT163833

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 7.54
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
cleavage 12
poly 2
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 14 99.12 Very High Very High Very High
rheumatoid arthritis 40 98.80 Very High Very High Very High
aspirin 9 91.72 High High
adenocard 1 91.52 High High
Osteoarthritis 21 87.68 High High
Arthritis 27 81.84 Quite High
metalloproteinase 8 71.36 Quite High
cINOD 4 67.68 Quite High
Inflammation 18 67.00 Quite High
Inflammatory mediators 4 57.04 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 174 99.80 Very High Very High Very High
Cancer 91 99.00 Very High Very High Very High
Rheumatoid Arthritis 40 98.80 Very High Very High Very High
Breast Cancer 15 97.68 Very High Very High Very High
Necrosis 9 93.32 High High
Osteoarthritis 21 87.68 High High
Death 39 86.28 High High
Lung Cancer 2 86.20 High High
Arthritis 33 81.84 Quite High
Disease 12 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, apoptosis was synergistically induced by the combination treatment, as evidenced by caspase-3 activation and PARP cleavage.
Positive_regulation (activation) of Localization (cleavage) of PARP in cleavage associated with apoptosis
1) Confidence 0.28 Published 2010 Journal Mol. Carcinog. Section Abstract Doc Link 19908241 Disease Relevance 0.99 Pain Relevance 0.49
In contrast, cell-cycle regulator p27(KIP1), caspase activity as well as poly-ADP ribose polymerase (PARP) cleavage were increased.
Positive_regulation (increased) of Localization (cleavage) of PARP in cleavage
2) Confidence 0.28 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.89 Pain Relevance 0.45
In contrast, cell-cycle regulator p27(KIP1), caspase activity as well as poly-ADP ribose polymerase (PARP) cleavage were increased.
Positive_regulation (increased) of Localization (cleavage) of poly-ADP ribose polymerase in cleavage
3) Confidence 0.25 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.89 Pain Relevance 0.45
In contrast, radiation up to 10 Gy was not sufficient to induce significant PARP-cleavage (Fig. 9C and data not shown).
Positive_regulation (induce) of Localization (cleavage) of PARP in cleavage
4) Confidence 0.24 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1475859 Disease Relevance 0.99 Pain Relevance 0
exerts potent proapoptotic effects in cardiomyocytes in vitro and in the myocardium in vivo, characterized by the activation of caspase-3 and the cleavage of PARP.
Positive_regulation (activation) of Localization (cleavage) of PARP in cleavage
5) Confidence 0.05 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570581 Disease Relevance 0.71 Pain Relevance 0.08
It suppresses the expression of cyclin D1, which is deregulated in several types of tumor, and it also induces apoptosis in tumor cells by activating caspase-8, which leads to cleavage of Bid, thus resulting in sequential release of mitochondrial cytochrome c and activation of caspase-9 and caspase-3, cleavage of poly ADP ribose polymerase (PARP) and apoptosis of tumor cells.
Positive_regulation (activation) of Localization (cleavage) of ribose polymerase in poly associated with cancer and apoptosis
6) Confidence 0.04 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.11 Pain Relevance 0.07
-induced cleavage of poly ADP-ribose polymerase protein and apoptosis.
Positive_regulation (induced) of Localization (cleavage) of ADP-ribose polymerase protein in cleavage associated with apoptosis
7) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.97 Pain Relevance 0.61

General Comments

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