INT16385

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Context Info
Confidence 0.41
First Reported 1980
Last Reported 2010
Negated 9
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 9.98
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
plasma 2
cleavage 2
hepatocytes 1
skin 1
respiratory 1
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 8 99.52 Very High Very High Very High
lidocaine 4 99.12 Very High Very High Very High
aspirin 9 98.86 Very High Very High Very High
Inflammatory mediators 2 96.12 Very High Very High Very High
Chronic pancreatitis 4 94.56 High High
Antihistamine 3 86.96 High High
neuralgia 1 85.68 High High
corticosteroid 2 85.44 High High
headache 11 85.12 High High
spastic colon 1 83.92 Quite High
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 4 100.00 Very High Very High Very High
Mumps 2 100.00 Very High Very High Very High
Cytomegalovirus Infection 1 100.00 Very High Very High Very High
Pain 6 99.52 Very High Very High Very High
Disease 212 97.64 Very High Very High Very High
Congenital Anomalies 10 97.56 Very High Very High Very High
Infection 124 97.48 Very High Very High Very High
Flavivirus Infection 240 97.12 Very High Very High Very High
Dengue 312 97.08 Very High Very High Very High
INFLAMMATION 26 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The concentrations of C3, the marker of xenogeneic reactions, did not change significantly, indicating that no hyperacute xenogeneic reaction occurred in our series.
Neg (not) Regulation (change) of C3
1) Confidence 0.41 Published 1999 Journal Cell Transplant Section Abstract Doc Link 10478723 Disease Relevance 0.14 Pain Relevance 0.18
The serum concentrations of C3, C4, and C1 esterase inhibitor remained unchanged.
Neg (unchanged) Regulation (unchanged) of C3
2) Confidence 0.31 Published 1991 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 1827928 Disease Relevance 0.65 Pain Relevance 0.08
Samples of venous blood from this extremity demonstrated a transient rise in plasma histamine levels without any significant change in serum hemolytic complement activity or in C3, C4, or factor B.
Neg (without) Regulation (change) of C3 in plasma
3) Confidence 0.27 Published 1981 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 6161144 Disease Relevance 0.66 Pain Relevance 0.12
Primary outcomes included diarrheal and respiratory morbidity, growth, and anxiety and complement C3, C-reactive protein, serum cortisol, transferrin, and ferritin values.
Regulation (values) of complement C3 in respiratory
4) Confidence 0.26 Published 2010 Journal Am. J. Clin. Nutr. Section Body Doc Link 20720257 Disease Relevance 0.08 Pain Relevance 0
The viability of porcine hepatocytes, lactate dehydrogenase (LDH) levels, lidocaine clearance, porcine albumin production, and changes in complement (C3) levels were measured.
Regulation (changes) of C3 in hepatocytes associated with lidocaine
5) Confidence 0.25 Published 1999 Journal Cell Transplant Section Abstract Doc Link 10478723 Disease Relevance 0.15 Pain Relevance 0.18
Complement study during acute and asymptomatic periods revealed normal values of C1 esterase inhibitor, C1q, C3, C4, functional activity of C1 inhibitor and CH50.
Regulation (values) of C3
6) Confidence 0.20 Published 2005 Journal Allergol Immunopathol (Madr) Section Abstract Doc Link 15777525 Disease Relevance 0.83 Pain Relevance 0.18
When we considered the levels of factors D and H together as an indicator of (C3bBb) C3 convertase regulation, we found that the plasma levels of these regulatory proteins in DHF patients favored the formation of the (C3bBb) C3 convertase, whereas its formation was inhibited in DF patients (p<0.0001).


Regulation (rtase regu) of C3 in plasma associated with flavivirus infection and dengue
7) Confidence 0.19 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2728508 Disease Relevance 1.23 Pain Relevance 0
On immunofluorescence microscopy, IgA and C3 deposits were detected in mesangial areas.
Regulation (detected) of C3
8) Confidence 0.18 Published 2009 Journal J. Nephrol. Section Abstract Doc Link 19810002 Disease Relevance 0.66 Pain Relevance 0.09
Since the laboratory kits used were not the same in all centers, the normal values for anti-dsDNA, C3, and C4 levels differed among centers.
Regulation (values) of C3
9) Confidence 0.18 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2659367 Disease Relevance 0.18 Pain Relevance 0
Thus, the log-ratios in concentration of factor H over factor D allow the study of how these two proteins are regulating the alternative pathway C3bBb C3 convertase levels, however it does not directly indicate the amount of active convertase.


Regulation (regulating) of C3
10) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.38 Pain Relevance 0
But since these two factors have antagonistic effects on the modulation of the activity of the C3bBb C3 convertase, the elevated levels of one could compensate for the levels of the other, we decided to analyze ratios of both factors.
Regulation (modulation) of C3
11) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.09 Pain Relevance 0
A significant increase of serum IgM together with normal values of C3 and C4 and without circulating immunocomplexes was found.
Regulation (values) of C3
12) Confidence 0.16 Published 1983 Journal Minerva Med. Section Abstract Doc Link 6408533 Disease Relevance 0.26 Pain Relevance 0.16
There were no significant changes in C4 or C3 across treatment groups.


Neg (no) Regulation (changes) of C3
13) Confidence 0.14 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0 Pain Relevance 0
Moreover, SGE had no effect on the cleavage of 125I-C3 into 125I-C3b by preformed C3bBb or when it was added simultaneously with C3b, factor B and factor D.
Neg (no) Regulation (effect) of C3 in cleavage
14) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Immune responifveness was assessed by immunoglobulin serum levels, non specific autoantibody formation, C3 levels, antistreptolysin reaction, antibody titer against Toxoplasma gondii, E. coli, Herpes simplex-, Mumps- and Cytomegalovirus and screening for soluble immune-complexes (PEG precipitation assay), number of T- and B-lymphocytes, lymphocyte responsiveness to PHA, PPD, tetatoxoid and mumps-antigen in a whole blood assay, skin testing with candidin, trichophytin, tuberculin and streptokinase and HLA-typing.
Regulation (responsiveness) of C3 in skin associated with mumps, herpes simplex virus and cytomegalovirus infection
15) Confidence 0.05 Published 1980 Journal Allerg Immunol (Leipz) Section Abstract Doc Link 6451161 Disease Relevance 0.57 Pain Relevance 0.17
Immunologically, elevated serum concentrations of IgG, IgA, and complements (C3, C4) were found in 33%, 20%, and 17%, respectively.
Regulation (concentrations) of C3
16) Confidence 0.04 Published 1993 Journal Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi Section Abstract Doc Link 8237359 Disease Relevance 0.94 Pain Relevance 0.27
Aspirin therapy greatly reduced the pain assessments but had no effect on plasma concentrations of IgG, IgA, IgM, complement component C3, nor on ESR, haemoglobin, leucocyte count, nor ring size.
Neg (no) Regulation (effect) of C3 associated with pain and aspirin
17) Confidence 0.04 Published 1980 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 6158390 Disease Relevance 0.17 Pain Relevance 0.31
The blockade of the complement cascade at the level of C5 does not affect early complement components (such as C3 and its cleavage products), preserving pivotal functions leading to clearance of immune complexes and microorganisms (Matis and Rollins 1995).
Neg (not) Regulation (affect) of C3 in cleavage
18) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 0.93 Pain Relevance 0.13
Of soluble immune parameters, C3 and C4 were not affected by treatment, whereas IgG 0.96 ± 0.12 vs 0.91 ± 0.14 and IgA 2.15 ± 0.79 vs 2.01 ± 0.72 levels were decreased.
Neg (not) Regulation (affected) of C3
19) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922090 Disease Relevance 0 Pain Relevance 0
Laboratory assays taken at presentation, were within normal limits with the exception of raised IgA in 14/30 (46%), elevated C3 values in 1/30 (3.3%) (Table 2), and high ASO titers (> 200 IU/ml) in 17/30 (56%).
Neg (exception) Regulation (values) of C3
20) Confidence 0.01 Published 2008 Journal BMC Pediatr Section Body Doc Link PMC2542358 Disease Relevance 1.05 Pain Relevance 0.03

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