INT163872

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.52
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TSHR) cell-cell signaling (TSHR) signal transducer activity (TSHR)
Anatomy Link Frequency
thyroid 4
TSHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Ultiva 4 88.16 High High
anesthesia 2 76.92 Quite High
Inflammation 13 52.12 Quite High
Serotonin 2 18.24 Low Low
cytokine 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Acupuncture 2 5.00 Very Low Very Low Very Low
drug abuse 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Disease 34 99.26 Very High Very High Very High
Hyperemesis Gravidarum 53 98.64 Very High Very High Very High
Graves' Ophthalmopathy 31 97.28 Very High Very High Very High
Heart Rate Under Development 3 96.56 Very High Very High Very High
Arrhythmias 2 Under Development 3 95.92 Very High Very High Very High
Hyperthyroidism 5 92.32 High High
Autoimmune Disease 22 91.76 High High
Muscle Disease 12 89.60 High High
Disorder Of Lipid Metabolism 3 84.92 Quite High
Graves Disease 1 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further investigations revealed an elevated serum free thyroxin level and suppressed thyroid-stimulating hormone (TSH).
Negative_regulation (suppressed) of thyroid-stimulating hormone in thyroid
1) Confidence 0.42 Published 2009 Journal Masui Section Abstract Doc Link 19860236 Disease Relevance 1.00 Pain Relevance 0.46
This may be initiated in the thyroid where calsequestrin expression is upregulated, possibly due to a stimulatory effect of TSH-r antibodies.
Negative_regulation (effect) of TSH-r in thyroid
2) Confidence 0.39 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2874268 Disease Relevance 0.77 Pain Relevance 0.03
Lithium has been found to interfere with the production of thyroid hormones including the inhibition of the thyroid stimulating hormone (TSH)-responsive adenylate cyclase and PKC in thyroid cells [22-24].
Negative_regulation (inhibition) of thyroid stimulating hormone in thyroid
3) Confidence 0.17 Published 2008 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2531078 Disease Relevance 0.53 Pain Relevance 0
Hyperthyroidism with normal fT3 and fT4 levels, but decreased levels of thyroid stimulating hormone (TSH), may also be implicated in HG [37,38].
Negative_regulation (decreased) of thyroid stimulating hormone in thyroid associated with thyroid disease and hyperemesis gravidarum
4) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2913953 Disease Relevance 1.23 Pain Relevance 0

General Comments

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