INT163878

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 3.35
Pain Relevance 4.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npcd) biological_process (Npcd) cytoplasm (Npcd)
Anatomy Link Frequency
brain 2
muscle 1
superior 1
cortex 1
mesencephalon 1
Npcd (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 350 100.00 Very High Very High Very High
Morphine 689 99.74 Very High Very High Very High
Calcitonin gene-related peptide 10 99.14 Very High Very High Very High
Dopamine 119 98.32 Very High Very High Very High
medulla 6 97.60 Very High Very High Very High
withdrawal 36 92.56 High High
Opioid 112 92.12 High High
midbrain 15 90.12 High High
antagonist 42 89.20 High High
narcan 20 85.88 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 459 99.52 Very High Very High Very High
Overactive Bladder 5 93.88 High High
Obesity 3 93.12 High High
Opiate Addiction 32 92.56 High High
Targeted Disruption 75 89.36 High High
Headache 1 85.28 High High
Hypertrophy 3 81.00 Quite High
Drug Dependence 49 79.88 Quite High
Brain Tumor 1 73.84 Quite High
Disease 21 71.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcitonin gene-related peptide (CGRP) is a polypeptide produced by alternative processing of calcitonin gene transcripts and is endowed with important systemic physiological effects.
Gene_expression (processing) of transcripts associated with calcitonin gene-related peptide
1) Confidence 0.05 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19860701 Disease Relevance 0.09 Pain Relevance 0.37
Morphine treatment altered the expression of 618 transcripts covered by 661 probe sets (FDR < 1%, rank > 3; Additional data file 1).
Gene_expression (expression) of transcripts associated with morphine
2) Confidence 0.02 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.81 Pain Relevance 0.43
Comparison of striatal gene expression profiles of the selected strains of mice indicated that expression of 2,870 transcripts was affected by genetic background.
Gene_expression (expression) of transcripts associated with sprains and strains
3) Confidence 0.02 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.52 Pain Relevance 0.67
Acute morphine reduced the expression of 69 transcripts, and for 29 of them these changes were also observed after repeated injections.
Gene_expression (expression) of transcripts associated with morphine
4) Confidence 0.02 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.13 Pain Relevance 0.80
Furthermore, complex strain-specific and region-specific expression patterns of a number of transcripts were recently reported [19].
Gene_expression (expression) of transcripts associated with sprains and strains
5) Confidence 0.02 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.57 Pain Relevance 0.50
In human heart muscle several TRPC transcripts have been detected.
Gene_expression (detected) of transcripts in muscle
6) Confidence 0.02 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.07 Pain Relevance 0.06
The occurrence of TRPM4 mRNA showed the largest variation among the tested tissues and, in contrast to all other transcripts a low expression in brain regions (Fig. 1, columns 16–21).
Gene_expression (expression) of transcripts in brain
7) Confidence 0.02 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.28
Brain regions showed the overall strongest expression of TRP channel transcripts and at the same time the highest diversity of TRP channel gene expression.
Gene_expression (expression) of transcripts in Brain associated with trp channel
8) Confidence 0.02 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.26
Thus, to date RT-PCR seems to be the superior method for studying gene expression of low abundance transcripts such as TRP channel mRNAs.


Gene_expression (expression) of transcripts in superior associated with trp channel
9) Confidence 0.02 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.09
In addition TRPV4 transcripts were found at high levels in these two organs.
Gene_expression (found) of transcripts
10) Confidence 0.02 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.03
In situ hybridization revealed co-expression of transcripts on the cellular level and widely confirmed the data obtained with RT-PCR.


Gene_expression (expression) of transcripts
11) Confidence 0.02 Published 2006 Journal BMC Genomics Section Abstract Doc Link PMC1557673 Disease Relevance 0.25 Pain Relevance 0.17
In contrast, DAT gene transcripts are not detected in the mouse ventral mesencephalon until DA axons reach the target at about E15, suggesting that during ontogeny, DA synthesis, and high-affinity uptake develop asynchronously and in a non-correlated fashion [27].
Neg (not) Gene_expression (detected) of transcripts in mesencephalon associated with dopamine
12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.37 Pain Relevance 0.41
However, compared to the TRPC transcripts, TRPV2 and 4 mRNAs were expressed at much lower levels reaching only 3–10% of those of TRPC3 and TRPC4 (Fig. 2B and 3).
Gene_expression (expressed) of transcripts
13) Confidence 0.01 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0 Pain Relevance 0.03
The cortex expresses Avpr1a transcripts primarily in the zona glomerulosa (Guillon et al. 1995; Grazzini et al. 1996) where this receptor regulates steroid secretion in vitro (Grazzini et al. 1998).
Gene_expression (expresses) of transcripts in cortex
14) Confidence 0.01 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.54 Pain Relevance 0.18

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