INT163889

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.00
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Calcrl) endosome (Calcrl) endoplasmic reticulum (Calcrl)
plasma membrane (Calcrl) lysosome (Calcrl) signal transducer activity (Calcrl)
Anatomy Link Frequency
lobes 2
Calcrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 28 100.00 Very High Very High Very High
Inflammatory mediators 1 86.04 High High
calcitonin gene related peptide 1 85.72 High High
Trigeminal ganglion neurons 1 81.60 Quite High
headache 3 73.72 Quite High
trigeminal ganglion 1 70.64 Quite High
cytokine 23 35.36 Quite Low
antagonist 39 22.96 Low Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 44 99.68 Very High Very High Very High
Uterine Fibroids 72 90.52 High High
INFLAMMATION 29 85.64 High High
Ganglion Cysts 3 80.72 Quite High
Apoptosis 10 75.28 Quite High
Headache 3 73.72 Quite High
Rheumatoid Arthritis 31 13.36 Low Low
Stress 48 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of CALCRL expression in the tumor and in response to estrogen may implicate two important aspects of the tumor growth, that is, cell proliferation and angiogenesis.
Regulation (regulation) of Gene_expression (expression) of CALCRL associated with cancer
1) Confidence 0.21 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.69 Pain Relevance 0.04
Gene expression of CGRP and the CGRP-receptor components, receptor activity-modifying protein 1, receptor component protein and calcitonin receptor-like receptor was measured by quantitative RT-PCR.
Regulation (measured) of Gene_expression (expression) of calcitonin receptor-like receptor associated with calcitonin gene-related peptide
2) Confidence 0.21 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19864020 Disease Relevance 0.30 Pain Relevance 0.76
The mRNAs coding for RAMP-1 and -3 are detected in the anterior and intermediate lobes (631) and, during lactation, the expression of RAMP-3 doubles whereas levels of CLR and RAMP-1 do not change (631).
Neg (not) Regulation (change) of Gene_expression (levels) of CLR in lobes
3) Confidence 0.20 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.04

General Comments

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