INT16389

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Context Info
Confidence 0.67
First Reported 1984
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 80
Total Number 81
Disease Relevance 36.88
Pain Relevance 6.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plg) extracellular space (Plg) extracellular region (Plg)
Anatomy Link Frequency
eyes 9
uterine 8
retina 2
fibroblasts 2
lung 2
Plg (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 328 100.00 Very High Very High Very High
metalloproteinase 81 100.00 Very High Very High Very High
Morphine 25 100.00 Very High Very High Very High
analgesia 4 100.00 Very High Very High Very High
agonist 116 99.82 Very High Very High Very High
Inflammation 292 99.58 Very High Very High Very High
Central nervous system 10 99.36 Very High Very High Very High
aspirin 7 98.96 Very High Very High Very High
opiate 1 98.92 Very High Very High Very High
antagonist 17 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 340 100.00 Very High Very High Very High
Pyoderma Gangrenosum 70 100.00 Very High Very High Very High
Infection 61 100.00 Very High Very High Very High
Aggression 4 100.00 Very High Very High Very High
Targeted Disruption 101 99.98 Very High Very High Very High
Cancer 737 99.68 Very High Very High Very High
Diabetes Mellitus 1657 99.62 Very High Very High Very High
Age-related Macular Degeneration 139 99.62 Very High Very High Very High
INFLAMMATION 333 99.58 Very High Very High Very High
Asthma 125 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects on offensive aggression of the endogenous peptide-leucyl-glycinamide (PLG, MIF-1) and the exogenous opiate antagonist, naloxone, were examined in male mice.
Gene_expression (aggression) of PLG associated with antagonist, aggression, narcan and opiate
1) Confidence 0.67 Published 1986 Journal Life Sci. Section Abstract Doc Link 2877382 Disease Relevance 0.33 Pain Relevance 0.35
Prolyl-leucyl-glycinamide (PLG) at a low dose (10 ng/mouse) administered intracerebroventricularly (i.c.v.) did not affect morphine analgesia, but produced a greater increase in the ED50 of morphine-pretreated (100 mg/kg of morphine sulfate) mice as compared to control mice.
Gene_expression (produced) of PLG associated with analgesia and morphine
2) Confidence 0.59 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6148243 Disease Relevance 0.20 Pain Relevance 1.17
Several groups have obtained evidence that resveratrol treatment increases the expression of the plasminogen activators t-PA and u-PA, suggesting that resveratrol could lead to plasminogen endoproteolysis and plasmin activation (Figure 1) [47,48].
Gene_expression (expression) of plasminogen
3) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.24 Pain Relevance 0
The plasminogen system
Gene_expression (The) of plasminogen system
4) Confidence 0.52 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.13 Pain Relevance 0
The extracellular serine protease tissue plasminogen activator (tPA) that converts plasminogen into plasmin is abundantly expressed throughout the central nervous system.
Gene_expression (expressed) of plasminogen in central nervous system associated with central nervous system
5) Confidence 0.36 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15948318 Disease Relevance 0.14 Pain Relevance 0.70
For example, production of two of the most well known and widely studied angiogenesis inhibitors – angiostatin and endostatin – has recently halted [33].
Gene_expression (production) of angiostatin
6) Confidence 0.33 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.62 Pain Relevance 0
So far, lentiviral vectors expressing matrix metalloproteinase-2 (MMP-2), angiostatin and endostatin have been developed [136,137].
Gene_expression (expressing) of angiostatin associated with metalloproteinase
7) Confidence 0.33 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.72 Pain Relevance 0.05
There was no angiostatin gene expression in normal control eyes (Figure 1, lane A) and eyes injected with rAAV-lacZ at 1, 5, 10, and 15 days after induction of diabetes (Figure 1, lanes B-E).
Neg (no) Gene_expression (expression) of angiostatin in eyes associated with diabetes mellitus
8) Confidence 0.31 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.50 Pain Relevance 0
In the eyes injected with rAAV-angiostatin, angiostatin gene expression was detected at 1, 5, 10, and 15 days after induction of diabetes (Figure 1, lanes F-I).
Gene_expression (expression) of angiostatin in eyes associated with diabetes mellitus
9) Confidence 0.31 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.74 Pain Relevance 0
We then assessed the impact of COX-2 down-regulation on airway inflammation, lung function, and PG production.


Gene_expression (production) of PG in lung associated with inflammation
10) Confidence 0.30 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.68 Pain Relevance 0.08
Rather than induce complete inhibition of COX-2 production or impair its activity, the inhibitory strategy used in our experiment was intended to mimic the described reduced production of COX-2 [5-7] and hence PG [4,8,39] in asthma.
Gene_expression (production) of PG associated with asthma
11) Confidence 0.30 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.35 Pain Relevance 0.04
AAV-mediated stable expression of angiostatin slowed tumor growth and prolonged survival in the highly aggressive B16F10 melanoma and Lewis lung carcinoma models of experimental metastasis.
Gene_expression (expression) of angiostatin in lung associated with melanoma, cancer, lewis lung carcinoma and metastasis
12) Confidence 0.29 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 1.04 Pain Relevance 0
We have previously reported that a recombinant adeno-associated virus vector expressing angiostatin (rAAV-angiostatin) suppressed laser-induced choroidal neovascularization [8].
Gene_expression (expressing) of angiostatin associated with age-related macular degeneration
13) Confidence 0.27 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 1.39 Pain Relevance 0
We previously reported suppression of laser-induced choroidal neovascularization by an rAAV vector expressing angiostatin [8].
Gene_expression (expressing) of angiostatin associated with age-related macular degeneration
14) Confidence 0.27 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.83 Pain Relevance 0.06
Titers of rAAV-angiostatin and rAAV-lacZ were determined by dot blot hybridization using angiostatin cDNA and lacZ as probes [25].


Gene_expression (using) of angiostatin cDNA
15) Confidence 0.27 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.32 Pain Relevance 0
Further research is warranted to explore the effect of rAAV-angiostatin on PEDF expression.
Gene_expression (expression) of angiostatin
16) Confidence 0.27 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.82 Pain Relevance 0.04
This COX-2-driven modulation is associated with reduced ability of airway cells to synthesize PGE2, but apparently not PGD2, as might be deduced from the expression of the corresponding PG synthases.
Gene_expression (expression) of PG
17) Confidence 0.27 Published 2008 Journal Respir Res Section Body Doc Link PMC2600823 Disease Relevance 0.34 Pain Relevance 0.05
Recently, using a recombinant adeno-associated virus (AAV) encoding kringles 1–3 of human angiostatin, scientists were able to achieve continuous and sustained expression of angiostatin in the sera of mice for more than 6 months following a single injection of recombinant vector [62].
Gene_expression (expression) of angiostatin
18) Confidence 0.26 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.94 Pain Relevance 0
Recently, targeted angiostatin and endostatin gene transfer [24,25] has been attempted as a means to halt angiogenesis in a mouse tumor model.
Gene_expression (transfer) of angiostatin associated with cancer
19) Confidence 0.26 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.67 Pain Relevance 0.08
Generation of rAAV-angiostatin
Gene_expression (Generation) of angiostatin
20) Confidence 0.24 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.26 Pain Relevance 0

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