INT163895

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GRIN2B) plasma membrane (GRIN2B)
Anatomy Link Frequency
urethra 4
GRIN2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.20 Very High Very High Very High
Pain 2 96.08 Very High Very High Very High
referred pain 2 94.64 High High
intrathecal 2 90.84 High High
Dorsal horn 2 78.72 Quite High
Disease Link Frequency Relevance Heat
Stress Incontinence 10 99.16 Very High Very High Very High
Low Back Pain 2 96.36 Very High Very High Very High
Referred Pain 2 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All these results suggest that EphBR-ephrinB interactions, which provoke Src-family kinase-dependent NMDAR NR2B phosphorylation at the lumbosacral spinal cord level, are involved in cross-organ sensitization, contributing to the development of viscero-visceral referred pain between the bowel and the urethra.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of NR2B in urethra associated with stress incontinence, referred pain and spinal cord
1) Confidence 0.09 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.55 Pain Relevance 0.29
Endogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of NR2B in urethra associated with stress incontinence
2) Confidence 0.08 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Title Doc Link 19864302 Disease Relevance 0.44 Pain Relevance 0.19

General Comments

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