INT1639

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2011
Negated 3
Speculated 3
Reported most in Abstract
Documents 107
Total Number 110
Disease Relevance 13.86
Pain Relevance 90.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
brain 3
DRG 3
SH-SY5Y 2
EM-2 2
embryonic kidney 2
OPRM1 (Homo sapiens)
OPRM1 - S268P (1)
Pain Link Frequency Relevance Heat
opioid receptor 842 100.00 Very High Very High Very High
narcan 759 100.00 Very High Very High Very High
Opioid 751 100.00 Very High Very High Very High
mu opioid receptor 663 100.00 Very High Very High Very High
Morphine 625 100.00 Very High Very High Very High
antagonist 253 100.00 Very High Very High Very High
tolerance 181 100.00 Very High Very High Very High
opiate 111 100.00 Very High Very High Very High
Enkephalin 66 100.00 Very High Very High Very High
Opioid receptor 1 32 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Diabetes Mellitus 13 99.68 Very High Very High Very High
Ganglion Cysts 24 99.16 Very High Very High Very High
Pain 163 99.08 Very High Very High Very High
Infection 5 99.04 Very High Very High Very High
Rheumatoid Arthritis 10 98.76 Very High Very High Very High
Nociception 32 98.56 Very High Very High Very High
Polycystic Ovary Syndrome 11 98.32 Very High Very High Very High
Substance Withdrawal Syndrome 8 97.72 Very High Very High Very High
Neuroblastoma 49 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been revealed that a deficiency in the MOR gene (Oprm1) or a difference in the 3' noncoding region of the gene markedly affects the sensitivity of mice to opioids.
Negative_regulation (deficiency) of MOR gene associated with opioid receptor and opioid
1) Confidence 0.59 Published 2005 Journal Gene Section Abstract Doc Link 16122888 Disease Relevance 0 Pain Relevance 0.51
It has been revealed that a deficiency in the MOR gene (Oprm1) or a difference in the 3' noncoding region of the gene markedly affects the sensitivity of mice to opioids.
Negative_regulation (deficiency) of Oprm1 associated with opioid receptor and opioid
2) Confidence 0.59 Published 2005 Journal Gene Section Abstract Doc Link 16122888 Disease Relevance 0 Pain Relevance 0.51
The results are consistent with tolerance being due to a functional reduction in the mu-opioid receptor reserve, probably by disruption of the receptor/GTP-binding protein interaction.
Negative_regulation (reduction) of mu-opioid receptor associated with tolerance and opioid receptor
3) Confidence 0.58 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1661836 Disease Relevance 0 Pain Relevance 1.25
Morphine treatment (10 microM) for 24 h decreased MOR mRNA levels in control, as well as RA- and TPA-differentiated cells.
Negative_regulation (decreased) of MOR mRNA associated with rheumatoid arthritis, opioid receptor and morphine
4) Confidence 0.57 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12754318 Disease Relevance 0.51 Pain Relevance 0.96
But the desensitization rate was increased by reduction of the mu-opioid receptor level with beta-furnaltrexamine (betaFNA).
Negative_regulation (reduction) of mu-opioid receptor associated with opioid receptor
5) Confidence 0.56 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10908307 Disease Relevance 0.05 Pain Relevance 0.39
One study examined mRNA expression in human brain tissue and reported a reduction in mRNA and OPRM protein (receptor) levels associated with the variant.44 A further study demonstrated altered receptor binding affinity.45 Another study however reported no difference in binding affinities between wild type receptor and the mu-opioid receptor coded for by this variant.46
Negative_regulation (reduction) of OPRM protein in brain associated with opioid receptor
6) Confidence 0.52 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004622 Disease Relevance 0.06 Pain Relevance 0.63
In this region, a significant decrease in mu-opioid receptor BP during sadness was observed in patients with MDD who did not respond to antidepressant treatment.
Negative_regulation (decrease) of mu-opioid receptor
7) Confidence 0.51 Published 2006 Journal Arch. Gen. Psychiatry Section Body Doc Link 17088500 Disease Relevance 0 Pain Relevance 0
RESULTS: The sustained sadness condition was associated with a statistically significant decrease in mu-opioid receptor BP in the left inferior temporal cortex of patients with MDD and correlated with negative affect ratings experienced during the condition.
Negative_regulation (decrease) of mu-opioid receptor in temporal cortex
8) Confidence 0.51 Published 2006 Journal Arch. Gen. Psychiatry Section Body Doc Link 17088500 Disease Relevance 0 Pain Relevance 0
These results indicate that the efficacy of opioids to produce activation of G proteins and rapid desensitization is distinct from their capacity to internalize mu-opioid receptors but that, contrary to some previous reports, morphine can produce rapid, homologous desensitization of MOP.
Negative_regulation (desensitization) of MOP associated with mu opioid receptor, opioid receptor, opioid and morphine
9) Confidence 0.51 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12642578 Disease Relevance 0 Pain Relevance 1.19
One explanation for the impaired capacity of diabetic endothelium to release NO was the diminished mu opiate receptor that was seen in diabetic endothelium.


Negative_regulation (diminished) of opiate receptor in endothelium
10) Confidence 0.50 Published 2002 Journal Acta Pharmacol. Sin. Section Body Doc Link 11866867 Disease Relevance 0 Pain Relevance 0
The 35-bp sequence (-694 to -660) was the hMOR homolog of the mMOR negative regulatory element, and it suppressed proximal promoter activity of the hMOR gene.
Negative_regulation (suppressed) of hMOR in proximal
11) Confidence 0.49 Published 2001 Journal DNA Cell Biol. Section Abstract Doc Link 11506703 Disease Relevance 0.21 Pain Relevance 0.46
After induction of the 5-HT(2A) receptor, coaddition of 5-HT with morphine now also resulted in desensitization, receptor internalization, and down-regulation of the mu opioid peptide receptor.
Negative_regulation (down-regulation) of mu opioid peptide receptor associated with opioid and morphine
12) Confidence 0.49 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18703670 Disease Relevance 0.06 Pain Relevance 1.63
In the absence of the 5-HT(2A) receptor, pretreatment with the enkephalin agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin but not with the alkaloid agonist morphine produced desensitization, internalization, and down-regulation of the mu opioid peptide receptor.
Negative_regulation (down-regulation) of mu opioid peptide receptor associated with agonist, enkephalin, opioid and morphine
13) Confidence 0.49 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18703670 Disease Relevance 0.08 Pain Relevance 1.61
The cascade starts with abrupt downregulation of mu opiate receptor activity together with elevation of gamma-aminobutyric acid (GABA) and dynorphin release in the striatum and the limbic system [19].
Negative_regulation (downregulation) of mu opiate receptor in striatum associated with gaba, dynorphin, opioid receptor 1 and limbic system
14) Confidence 0.48 Published 2006 Journal BMC Psychiatry Section Body Doc Link PMC1489929 Disease Relevance 0.66 Pain Relevance 1.19
Mu opiate receptor down-regulation by morphine and up-regulation by naloxone in SH-SY5Y human neuroblastoma cells.
Negative_regulation (down-regulation) of Mu opiate receptor in SH-SY5Y associated with neuroblastoma, narcan, opioid receptor 1 and morphine
15) Confidence 0.46 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8097244 Disease Relevance 0.19 Pain Relevance 0.96
The repression of the MOR gene secondary to SIVmac239 infection could be abolished by the demethylating agent 5-aza-2'-deoxycytidine.
Negative_regulation (repression) of MOR gene associated with repression, mu opioid receptor and infection
16) Confidence 0.44 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.76 Pain Relevance 0.43
Increased surface density of “free” MOP potentiates the endogenous opioid signaling and activates the cellular internalization machinery, secondarily causing the sharp reduction in MOP surface density.
Negative_regulation (reduction) of MOP associated with endogenous opioid and opioid receptor
17) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2602977 Disease Relevance 0.20 Pain Relevance 0.94
One possibility may be that MOP is replenished from the intracellular pool by faster recruitment of transporting vesicles to the plasma membrane.
Negative_regulation (replenished) of MOP in plasma associated with opioid receptor
18) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2602977 Disease Relevance 0.09 Pain Relevance 0.86
Expression of a dominant negative mutant G protein-coupled receptor kinase 2 (GRK2), GRK2-K220R, markedly attenuated the DAMGO-induced desensitization of MOR1, but it had no effect on morphine-induced MOR1 desensitization.
Negative_regulation (desensitization) of MOR1 associated with morphine
19) Confidence 0.43 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 1.49
Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells.
Negative_regulation (desensitization) of mu-opioid receptor in embryonic kidney associated with agonist and opioid receptor
20) Confidence 0.43 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16682505 Disease Relevance 0 Pain Relevance 1.35

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