INT163910

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.11
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 2
Il11ra1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 79 99.92 Very High Very High Very High
cINOD 4 98.84 Very High Very High Very High
cytokine 72 97.80 Very High Very High Very High
Pain 13 95.80 Very High Very High Very High
rheumatoid arthritis 12 94.28 High High
nociceptor 3 76.72 Quite High
antagonist 2 66.88 Quite High
Inflammatory response 7 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 84 99.92 Very High Very High Very High
Cancer 166 98.64 Very High Very High Very High
Disease 26 94.96 High High
Rheumatoid Arthritis 12 94.28 High High
Pain 9 84.64 Quite High
Mucositis 2 80.88 Quite High
Colitis 10 76.56 Quite High
Apoptosis 11 76.08 Quite High
Hypersensitivity 3 66.00 Quite High
Shock 3 53.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Meanwhile, systemic reduction of Stat3 expression in gp130Y757F;Stat3+/- mice not only prevented gastric tumour formation [31], but also reduced their susceptibility to colonic tumourigenesis in the CAC model [93].
Negative_regulation (reduction) of Gene_expression (/) of gp130Y757F associated with cancer
1) Confidence 0.39 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.91 Pain Relevance 0.07
Inhibitors of IL-6 or of its signal transducing receptor gp130 constitute a novel class of anti-inflammatory drugs, which raise great hopes for improved treatments of painful inflammatory diseases such as rheumatoid arthritis.
Negative_regulation (Inhibitors) of Gene_expression (transducing) of gp130 associated with pain, inflammation, rheumatoid arthritis, cinod and disease
2) Confidence 0.38 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19864560 Disease Relevance 0.71 Pain Relevance 0.65
In macrophages lacking the SOCS3 gene, or carrying a mutation of the SOCS3 binding site (Y759F) in gp130, not only IL-10 but also IL-6 suppressed LPS-induced TNF-?
Negative_regulation (mutation) of Gene_expression (only) of gp130 in macrophages
3) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.49 Pain Relevance 0.36

General Comments

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