INT163912

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 5.06
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Il11ra1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 14 98.36 Very High Very High Very High
nociceptor 3 96.80 Very High Very High Very High
cytokine 188 92.36 High High
Inflammation 189 92.00 High High
rheumatoid arthritis 111 91.24 High High
Arthritis 44 90.76 High High
cINOD 4 86.80 High High
Central nervous system 3 82.32 Quite High
GABAergic 9 50.00 Quite Low
Osteoarthritis 5 40.88 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 232 99.32 Very High Very High Very High
Hypersensitivity 6 98.76 Very High Very High Very High
Acute-phase Reaction 1 94.16 High High
Pain 9 92.56 High High
Targeted Disruption 37 92.12 High High
INFLAMMATION 187 92.00 High High
Disease 146 91.08 High High
Experimental Arthritis 6 90.76 High High
Arthritis 36 87.28 High High
Multiple Sclerosis 57 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found indeed that the IL-6/gp130 ligand-receptor complex induced heat hypersensitivity both in vitro and in vivo.
gp130 Binding (ligand) of associated with hypersensitivity
1) Confidence 0.33 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19864560 Disease Relevance 1.26 Pain Relevance 0.99
IL-27 binds to a receptor composed of WSX-1/TCCR and gp130, the latter of which serves as a common signal transduction receptor for IL-6-related family members.
gp130 Binding (binds) of
2) Confidence 0.16 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.10 Pain Relevance 0.33
Canonical IL-6 signaling involves binding of IL-6 to its cognate receptor (IL-6R)[11] to cause dimerization of two gp130 proteins, which in turn activate intracellular signaling and transcriptional regulation through the Jak/STAT (janus kinase/signal transducers and activators of transcription) pathway, and the transcription factor SOCS3 (suppressor of cytokine signaling-3).
gp130 Binding (dimerization) of associated with cytokine
3) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.72 Pain Relevance 0.22
SOCS3 protein was strongly induced by both IL-6 and IL-10 in the presence of LPS, but selectively inhibited IL-6 signaling, because SOCS3 bound the IL-6 receptor, gp130 (Y759), but not the IL-10 receptor [43].
gp130 Binding (bound) of
4) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.50 Pain Relevance 0.33
Although SOCS3 binds with a much higher affinity to a gp130 phosphopeptide around Tyr759 than to phospho-peptides derived from other receptors, such as leptin and erythropoietin receptors, multiple SOCS3-binding sites are predicted to exist in these receptors, which might compensate for weaker binding to individual sites.
gp130 Spec (might) Binding (binds) of
5) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0 Pain Relevance 0.03
Once IL-6 binds its receptor and gp130 homodimerization occurs, a signalling cascade is triggered.
gp130 Binding (binds) of
6) Confidence 0.06 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.75 Pain Relevance 0.16
Once IL-6 binds its receptor and gp130 homodimerization occurs, a signalling cascade is triggered.
gp130 Binding (homodimerization) of
7) Confidence 0.06 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.74 Pain Relevance 0.16

General Comments

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