INT163913

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 12.62
Pain Relevance 5.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 3
macrophages 1
endothelial cells 1
uterus 1
neurons 1
Il11ra1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 41 99.70 Very High Very High Very High
nociceptor 9 99.70 Very High Very High Very High
cytokine 272 99.08 Very High Very High Very High
cINOD 13 98.84 Very High Very High Very High
Inflammation 388 98.76 Very High Very High Very High
rheumatoid arthritis 18 94.28 High High
Inflammatory mediators 11 89.68 High High
antagonist 36 77.04 Quite High
Inflammatory response 29 72.76 Quite High
imagery 34 66.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 185 100.00 Very High Very High Very High
Necrosis 9 100.00 Very High Very High Very High
Pain 28 99.40 Very High Very High Very High
Hypoxia 262 99.30 Very High Very High Very High
Disease 429 99.28 Very High Very High Very High
INFLAMMATION 414 98.76 Very High Very High Very High
Rheumatoid Arthritis 138 94.28 High High
Leukemia 9 90.84 High High
Asthma 406 90.20 High High
Targeted Disruption 75 87.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results uncover the significance of gp130 expressed in peripheral pain sensing neurons in the pathophysiology of major clinical pain disorders and suggest their use as novel pain relieving agents in inflammatory and tumor pain.
Gene_expression (expressed) of gp130 in neurons associated with pain, inflammation and cancer
1) Confidence 0.69 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19864560 Disease Relevance 1.93 Pain Relevance 1.39
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
Gene_expression (expressed) of gp130 in sensory nerves associated with pain and nociceptor
2) Confidence 0.69 Published 2009 Journal J. Neurosci. Section Title Doc Link 19864560 Disease Relevance 1.24 Pain Relevance 1.26
Four genes found to be differentially expressed in IL11Ra-/- uterus compared to wild type at 48 h of decidualization were investigated at the protein level by immunohistochemistry using specific antibodies.
Gene_expression (expressed) of IL11Ra in uterus
3) Confidence 0.64 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
Meanwhile, systemic reduction of Stat3 expression in gp130Y757F;Stat3+/- mice not only prevented gastric tumour formation [31], but also reduced their susceptibility to colonic tumourigenesis in the CAC model [93].
Gene_expression (/) of gp130Y757F associated with cancer
4) Confidence 0.61 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.90 Pain Relevance 0.07
Inhibitors of IL-6 or of its signal transducing receptor gp130 constitute a novel class of anti-inflammatory drugs, which raise great hopes for improved treatments of painful inflammatory diseases such as rheumatoid arthritis.
Gene_expression (transducing) of gp130 associated with pain, inflammation, rheumatoid arthritis, cinod and disease
5) Confidence 0.60 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19864560 Disease Relevance 0.71 Pain Relevance 0.65
At 0 h, prior to application of the decidualizing stimulus on day 3 of pseudopregnancy, there were no reproducible differentially expressed genes between IL11Ra+/+ and IL11Ra-/- (Fig. 2A,2B).
Gene_expression (expressed) of IL11Ra
6) Confidence 0.57 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
Heterozygotes were interbred to produce wild-type (IL11Ra+/+) and IL-11R?
Gene_expression (produce) of IL11Ra
7) Confidence 0.50 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.07 Pain Relevance 0.09
These data, together with our finding that exposure to chronic hypoxia is associated with increased lung expression of IL-6R and gp-130 mRNA levels, strongly suggest that IL-6 may act partly as an inducer of PA-SMC migration during chronic hypoxia.
Gene_expression (expression) of gp-130 mRNA in lung associated with hypoxia
8) Confidence 0.32 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.25 Pain Relevance 0.05
These data, together with our finding that exposure to chronic hypoxia is associated with increased lung expression of IL-6R and gp-130 mRNA levels, strongly suggest that IL-6 may act partly as an inducer of PA-SMC migration during chronic hypoxia.
Gene_expression (levels) of gp-130 mRNA in lung associated with hypoxia
9) Confidence 0.28 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.25 Pain Relevance 0.03
Lung expression of IL-6, IL-6-R, and gp130 during normoxia and hypoxia
Gene_expression (expression) of gp130 in Lung associated with hypoxia
10) Confidence 0.25 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.61 Pain Relevance 0
In macrophages lacking the SOCS3 gene, or carrying a mutation of the SOCS3 binding site (Y759F) in gp130, not only IL-10 but also IL-6 suppressed LPS-induced TNF-?
Gene_expression (only) of gp130 in macrophages
11) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.48 Pain Relevance 0.35
Studies of IL-6 receptor, Gp130, and tumor necrosis factor (TNF-?)
Gene_expression (tumor necrosis factor) of Gp130 associated with necrosis and cancer
12) Confidence 0.22 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.72 Pain Relevance 0.43
Studies of IL-6 receptor, Gp130, and tumor necrosis factor (TNF-?)
Gene_expression (receptor) of Gp130 associated with necrosis and cancer
13) Confidence 0.22 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.71 Pain Relevance 0.43
While gp130 is expressed ubiquitously, IL-6R is predominantly expressed on hepatocytes, neutrophils, monocytes/macrophages and some lymphocytes [4].
Gene_expression (expressed) of gp130
14) Confidence 0.14 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.47 Pain Relevance 0.11
For example, endothelial cells and synoviocytes express gp130 but not IL-6R, and can therefore only respond to IL-6 in the presence of sIL-6R.
Neg (not) Gene_expression (express) of gp130 in endothelial cells
15) Confidence 0.11 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.21 Pain Relevance 0.03
chains that mainly function in hematopoietic and lymphoid cell systems, the IL-6 family of cytokines function extensively outside these systems as well, owing to the ubiquitous expression of gp130 [213].
Gene_expression (expression) of gp130 associated with cytokine
16) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.64 Pain Relevance 0.25
The observed increased expression of some genes, including nitric oxide synthase 2A [18-21], CD14 antigen [22], T cell receptor alpha locus [23], small inducible cytokine A5 (RANTES) [24], mucin [25,26], tryptases [27,28], cathepsin C [29], and possibly glutathione peroxidase 3 [30], spleen tyrosine kinase [31], and also cathepsin G [32], a serine protease, matches previously published results and confirms the implication of candidate genes already associated with asthma in previous studies.
Spec (observed) Gene_expression (expression) of locus in spleen associated with asthma and cytokine
17) Confidence 0.04 Published 2004 Journal BMC Genomics Section Body Doc Link PMC400730 Disease Relevance 0.86 Pain Relevance 0.17
This observation is consistent with a recently reported model that included LPS stimulated BMSC in which SB-203580 inhibited IL-6 and IL-11 mRNA expression[66].
Gene_expression (expression) of IL-11 mRNA
18) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.17 Pain Relevance 0
In this context, it is not surprising that expression from a genomic locus where the gene is under the control of its own promoter renders physiological levels of expression that are maintained stably [121].
Gene_expression (expression) of locus
19) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.41 Pain Relevance 0.04

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