INT163915

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.84
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 4
sensory nerves 2
Il11ra1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 13 99.88 Very High Very High Very High
nociceptor 3 99.88 Very High Very High Very High
Inflammation 69 96.24 Very High Very High Very High
cINOD 3 92.04 High High
rheumatoid arthritis 1 87.48 High High
cytokine 34 51.00 Quite High
Inflammatory response 6 42.28 Quite Low
chemokine 8 5.40 Low Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 174 99.60 Very High Very High Very High
Pain 9 98.16 Very High Very High Very High
INFLAMMATION 70 96.24 Very High Very High Very High
Disease 9 88.16 High High
Rheumatoid Arthritis 1 87.48 High High
Hypersensitivity 1 76.20 Quite High
Targeted Disruption 5 63.36 Quite High
Cancer 4 59.04 Quite High
Adhesions 12 50.04 Quite High
Primary Pulmonary Hypertension 96 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
Positive_regulation (role) of Gene_expression (expressed) of gp130 in sensory nerves associated with pain and nociceptor
1) Confidence 0.41 Published 2009 Journal J. Neurosci. Section Title Doc Link 19864560 Disease Relevance 1.24 Pain Relevance 1.26
These data, together with our finding that exposure to chronic hypoxia is associated with increased lung expression of IL-6R and gp-130 mRNA levels, strongly suggest that IL-6 may act partly as an inducer of PA-SMC migration during chronic hypoxia.
Positive_regulation (increased) of Gene_expression (expression) of gp-130 mRNA in lung associated with hypoxia
2) Confidence 0.28 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.30 Pain Relevance 0.05
These data, together with our finding that exposure to chronic hypoxia is associated with increased lung expression of IL-6R and gp-130 mRNA levels, strongly suggest that IL-6 may act partly as an inducer of PA-SMC migration during chronic hypoxia.
Positive_regulation (increased) of Gene_expression (expression) of gp-130 mRNA in lung associated with hypoxia
3) Confidence 0.21 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.30 Pain Relevance 0.05

General Comments

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