INT163925

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.23
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Epx)
Anatomy Link Frequency
eosinophil 2
T cells 2
Epx (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 6 93.60 High High
Analgesic 2 76.60 Quite High
Inflammation 36 76.04 Quite High
cytokine 48 5.00 Very Low Very Low Very Low
corticosteroid 10 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
lidocaine 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Common Cold 2 99.74 Very High Very High Very High
Respiratory Syncytial Virus 8 99.42 Very High Very High Very High
Parainfluenza Virus Infection 2 98.62 Very High Very High Very High
Asthma 56 97.92 Very High Very High Very High
INFLAMMATION 34 76.04 Quite High
Helminth Infection 4 70.68 Quite High
Infection 14 64.64 Quite High
Eosinophilia 34 63.60 Quite High
Pneumonia 2 56.88 Quite High
Apoptosis 154 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, recruitment of leukocytes, histamine release, and eosinophil peroxidase (EPO) and phospholipase A(2) (PLA(2)) activities were determined in bronchoalveolar lavage fluids (BALF) 24h after the antigen challenge. 4-Hydroxy-3-methoxybenzyl alcohol (12.5mg/kg) significantly (p<0.05) inhibited sRaw in IAR and in LAR by 51.97+/-4.96% and 39.93+/-3.46%, respectively, compared to that of the controls.
Localization (release) of EPO in eosinophil associated with alcohol
1) Confidence 0.51 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 19874915 Disease Relevance 0.40 Pain Relevance 0.20
Furthermore, recruitment of leukocytes, histamine release, and eosinophil peroxidase (EPO) and phospholipase A(2) (PLA(2)) activities were determined in bronchoalveolar lavage fluids (BALF) 24h after the antigen challenge. 4-Hydroxy-3-methoxybenzyl alcohol (12.5mg/kg) significantly (p<0.05) inhibited sRaw in IAR and in LAR by 51.97+/-4.96% and 39.93+/-3.46%, respectively, compared to that of the controls.
Localization (release) of eosinophil peroxidase in eosinophil associated with alcohol
2) Confidence 0.45 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 19874915 Disease Relevance 0.40 Pain Relevance 0.20
Eosinophil granule proteins are known for their ribonuclease activity (such as human eosinophil cationic protein (ECP, RNase 3) and eosinophil-derived neurotoxin (EDN, RNase 2), and at least 11 eosinophil associated ribonucleases (EAR) orthologs in mice) and have been shown to degrade single-stranded RNA-containing viruses.25 Interestingly, it has recently been shown that viruses (parainfluenza virus, respiratory syncytial virus (RSV), or rhinovirus) induce the release of eosinophil peroxidase (EPO) by eosinophils when co-incubated in the presence of antigen-presenting cells and T cells.26 In fact, ECP and EDN are the most divergent coding sequences in the entire human genome (compared with other primates).25 Despite their divergence, they have conserved ribonuclease activity across species, strongly implicating evolutionary pressure to preserve this critical enzymatic activity.
Localization (release) of EPO in T cells associated with common cold, parainfluenza virus infection and respiratory syncytial virus
3) Confidence 0.34 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.71 Pain Relevance 0
Eosinophil granule proteins are known for their ribonuclease activity (such as human eosinophil cationic protein (ECP, RNase 3) and eosinophil-derived neurotoxin (EDN, RNase 2), and at least 11 eosinophil associated ribonucleases (EAR) orthologs in mice) and have been shown to degrade single-stranded RNA-containing viruses.25 Interestingly, it has recently been shown that viruses (parainfluenza virus, respiratory syncytial virus (RSV), or rhinovirus) induce the release of eosinophil peroxidase (EPO) by eosinophils when co-incubated in the presence of antigen-presenting cells and T cells.26 In fact, ECP and EDN are the most divergent coding sequences in the entire human genome (compared with other primates).25 Despite their divergence, they have conserved ribonuclease activity across species, strongly implicating evolutionary pressure to preserve this critical enzymatic activity.
Localization (release) of eosinophil peroxidase in T cells associated with common cold, parainfluenza virus infection and respiratory syncytial virus
4) Confidence 0.34 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.71 Pain Relevance 0

General Comments

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