INT16395

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Context Info
Confidence 0.57
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 34
Disease Relevance 11.02
Pain Relevance 6.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CEBPZ) DNA binding (CEBPZ)
Anatomy Link Frequency
blood 4
brain 2
smooth muscle 1
coronary artery 1
occipital cortex 1
CEBPZ (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 67 99.92 Very High Very High Very High
antagonist 8 99.86 Very High Very High Very High
anesthesia 57 99.78 Very High Very High Very High
addiction 71 99.44 Very High Very High Very High
ketamine 26 98.98 Very High Very High Very High
COX-2 inhibitor 5 98.10 Very High Very High Very High
Hippocampus 60 97.64 Very High Very High Very High
analgesia 36 97.56 Very High Very High Very High
ischemia 20 97.54 Very High Very High Very High
depression 39 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 68 99.92 Very High Very High Very High
Dyspnea 38 99.48 Very High Very High Very High
Pathologic Constriction 8 99.44 Very High Very High Very High
Head Trauma 8 99.36 Very High Very High Very High
Disease 42 98.90 Very High Very High Very High
Vascular Dementia 5 98.42 Very High Very High Very High
Aging 5 98.00 Very High Very High Very High
Cardiovascular Disorder Under Development 2 97.96 Very High Very High Very High
Cv Unclassified Under Development 33 97.54 Very High Very High Very High
Sleep Disorders 122 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Etomidate has the benefits of decreasing ICP by reductions in CBF and CMRO2 and has the advantage of producing less cardiovascular depression than barbiturates or propofol, and preserving cerebral perfusion pressure [28, 29].
Gene_expression (reductions) of CBF associated with depression, cva and cardiovascular disorder under development
1) Confidence 0.57 Published 2010 Journal International Journal of Pediatrics Section Body Doc Link PMC2913544 Disease Relevance 1.44 Pain Relevance 0.30
The product of AVDO2 and CBF, which reflects cerebral metabolic oxygen consumption, remained constant (P = 0.364).
Gene_expression (product) of CBF
2) Confidence 0.57 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2531561 Disease Relevance 0 Pain Relevance 0.15
Hz forepaw stimulation) was calibrated to CBF data collected with the ASL technique (3?
Gene_expression (data) of CBF
3) Confidence 0.56 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2936934 Disease Relevance 0 Pain Relevance 0
Because of difficulties with the CBV measurement in human subjects, Grubb's relationship (Grubb et al., 1974) is usually used to estimate this component from measured CBF changes, where CBV?
Gene_expression (changes) of CBF
4) Confidence 0.56 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2936934 Disease Relevance 0.09 Pain Relevance 0.13
BOLD and CBF methods do not differ when applied to human and non-human subjects.
Gene_expression (methods) of CBF
5) Confidence 0.56 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2936934 Disease Relevance 0 Pain Relevance 0.17
Importantly, COX-2 inhibitors, a common medication in patients, were part of the pharmacological cocktail used to block the CBF response.
Gene_expression (response) of CBF associated with cox-2 inhibitor
6) Confidence 0.56 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2955428 Disease Relevance 0.42 Pain Relevance 0.08
Posterior temporal lobe, inferior parietal lobe and cerebellar cortex CBF was decreased bilaterally (Malizia et al. 1998), whereas on study showed increased CBF in the left hippocampus (Bisaga et al. 1998).
Gene_expression (decreased) of CBF in lobe associated with hippocampus
7) Confidence 0.55 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.29 Pain Relevance 0.57
The first patient, with only borderline ischemia and removal of the subdural hematoma within 3 hours, made a good recovery, while the second patient, with prolonged lower levels of CBF, remained in a persistent vegetative state.
Gene_expression (levels) of CBF associated with head trauma and ischemia
8) Confidence 0.53 Published 1994 Journal J. Neurosurg. Section Abstract Doc Link 8283273 Disease Relevance 1.18 Pain Relevance 0.28
BACKGROUND: In several animal studies, an increase in cerebral blood flow (CBF) produced by volatile anesthetics has been reported to resolve over time during prolonged anesthesia.
Gene_expression (produced) of CBF in blood associated with anesthesia
9) Confidence 0.53 Published 1996 Journal Anesthesiology Section Abstract Doc Link 8659783 Disease Relevance 0 Pain Relevance 0.46
The unchanging electroencephalographic pattern suggests that the former possibility is more likely and that the increase of CBF produced by volatile anesthetics is maintained over time without decay, which has been reported in several animal studies.
Gene_expression (produced) of CBF
10) Confidence 0.53 Published 1996 Journal Anesthesiology Section Body Doc Link 8659783 Disease Relevance 0 Pain Relevance 0
BACKGROUND: It is not clear whether the increase of cerebral blood flow (CBF) produced by volatile anesthetics is maintained during prolonged anesthesia.
Gene_expression (produced) of CBF in blood associated with anesthesia
11) Confidence 0.53 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9316956 Disease Relevance 0 Pain Relevance 0.33
Cerebrovascular responsiveness to changes in PaCO2 was calculated as specific reactivity (SR), the change in CBF divided by the change in PaCO2, expressed in mL.100 g-1.min-1.mm Hg-1.
Gene_expression (expressed) of CBF
12) Confidence 0.53 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1898686 Disease Relevance 0 Pain Relevance 0
Hyperventilation (IV), on the other hand, produced a distinct fall in CBF by 56% to a value that was 21% below the one obtained under normocapnia.
Gene_expression (produced) of CBF associated with dyspnea
13) Confidence 0.52 Published 1991 Journal Anaesthesist Section Abstract Doc Link 1827962 Disease Relevance 0.38 Pain Relevance 0.06
Ketamine is a N-methyl-D-aspartate (NMDA) antagonist which produces increases in CBF and CMRO2 [35, 36].
Gene_expression (produces) of CBF associated with ketamine and antagonist
14) Confidence 0.51 Published 2010 Journal International Journal of Pediatrics Section Body Doc Link PMC2913544 Disease Relevance 1.19 Pain Relevance 0.75
Therefore, CBF/CMRO2 during DHCPB increases favouring luxury perfusion of the brain.
Gene_expression (/) of CBF in brain
15) Confidence 0.50 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.14 Pain Relevance 0.03
Normal coupling of CBF/CMRO2 is present before and after CPB, as well as during normothermic CPB and ?
Gene_expression (/) of CBF
16) Confidence 0.50 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.14 Pain Relevance 0.03
In the patient group, increased CBF in the right orbitofrontal cortex was detected.
Gene_expression (detected) of CBF in cortex
17) Confidence 0.49 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.75 Pain Relevance 0.18
Additionally, CBF was higher in the left occipital cortex and lower bilaterally in the hippocampus and the amygdalae.
Gene_expression (higher) of CBF in occipital cortex associated with hippocampus
18) Confidence 0.49 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.74 Pain Relevance 0.15
min after CSD, the CBF response to whisker hair deflection in anesthetized rats (n?
Gene_expression (response) of CBF in hair
19) Confidence 0.49 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2955428 Disease Relevance 0.17 Pain Relevance 0.08
Altered vascular reactivity: effects of reduced CBF response on deoxy-Hb changes during functional activation
Gene_expression (response) of CBF
20) Confidence 0.49 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2955428 Disease Relevance 0.57 Pain Relevance 0.04

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