INT16396

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Context Info
Confidence 0.48
First Reported 1980
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 76
Total Number 77
Disease Relevance 30.03
Pain Relevance 21.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CEBPZ) DNA binding (CEBPZ)
Anatomy Link Frequency
blood 13
brain 8
neuronal 3
lobe 3
hippocampus 2
CEBPZ (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 17 99.98 Very High Very High Very High
lidocaine 10 99.98 Very High Very High Very High
depression 113 99.92 Very High Very High Very High
narcan 104 99.84 Very High Very High Very High
Opioid 119 99.76 Very High Very High Very High
methadone 149 99.36 Very High Very High Very High
Buprenorphine 140 99.32 Very High Very High Very High
Morphine 42 99.30 Very High Very High Very High
isoflurane 28 99.26 Very High Very High Very High
Hippocampus 117 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypothermia 76 99.98 Very High Very High Very High
Dyspnea 52 99.98 Very High Very High Very High
Depression 117 99.92 Very High Very High Very High
Hypocapnia 21 99.90 Very High Very High Very High
Opiate Addiction 12 99.80 Very High Very High Very High
Stress 42 99.74 Very High Very High Very High
Increased Venous Pressure Under Development 124 99.44 Very High Very High Very High
Encephalopathy 11 99.42 Very High Very High Very High
Neurological Disease 65 99.40 Very High Very High Very High
Pathologic Constriction 43 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increased CBF in the right dorsolateral prefrontal cortex, the left inferior temporal cortex and the left hippocampus-amydala complex was detected, additionally a decrease of CBF in the left temporal pole and bilaterally in the cerebellum.
Negative_regulation (decrease) of CBF in cortex associated with hippocampus
1) Confidence 0.48 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.60 Pain Relevance 0.28
In a PET study after phobic stimulation, SAD patients who had clinically improved under citalopram treatment had decreased CBF in both amygdalae, hippocampus, and in the paraamygdaloid, rhinal, and parahippocampal cortex compared to measurements before pharmacological treatment.
Negative_regulation (decreased) of CBF in hippocampus associated with phobia, positron emission tomography and hippocampus
2) Confidence 0.48 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.64 Pain Relevance 0.39
Under psychological stress, however, a reduction of CBF was found (Nutt 2001).
Negative_regulation (reduction) of CBF associated with stress
3) Confidence 0.48 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 1.00 Pain Relevance 0.21
Remifentanyl, however, could have a vasoconstrictive effect and thus decrease the basal CBF level in gray matter of the occipital lobe (Klimscha et al. 2003), which should not affect the findings of this study.
Negative_regulation (decrease) of CBF in lobe
4) Confidence 0.47 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.39 Pain Relevance 0.38
However, presuming intact neurovascular coupling, a reduction in neuronal activity should lead to a decrease in the CBF and BOLD signal.
Negative_regulation (decrease) of CBF in neuronal
5) Confidence 0.47 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.13 Pain Relevance 0.09
CBF was globally decreased during dipyridamole stress.
Negative_regulation (decreased) of CBF associated with stress
6) Confidence 0.43 Published 2002 Journal Neuroimage Section Abstract Doc Link 12169262 Disease Relevance 0.89 Pain Relevance 0.53
In a previous study, the authors found that CBF equivalent, an index of flow-metabolism relationship, was stable over 3 h, suggesting no decay over time in CBF for 3 h during volatile anesthesia in humans.
Negative_regulation (equivalent) of CBF associated with anesthesia
7) Confidence 0.43 Published 1997 Journal Anesthesiology Section Abstract Doc Link 9316956 Disease Relevance 0 Pain Relevance 0.34
Although hypothermia reduced baseline CBF by almost 50%, neurovascular coupling was preserved.
Negative_regulation (reduced) of CBF associated with hypothermia
8) Confidence 0.42 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2955428 Disease Relevance 0.81 Pain Relevance 0
A reduction in baseline CBF and baseline BOLD signal accompanied by an increase in the evoked CBF and BOLD response (Chen and Parrish, 2009) as well as reduced measures of resting state BOLD connectivity in the motor cortex (Rack-Gomer et al., 2009) have been described after caffeine intake.
Negative_regulation (reduction) of CBF in cortex
9) Confidence 0.42 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2955428 Disease Relevance 0.10 Pain Relevance 0.04
CONCLUSIONS: In humans given isoflurane anesthesia, a) ketamine reduced cerebrovascular response to CO(2), but cerebral blood flow (CBF) during hypercapnic conditions was comparable with controls, and b) although propofol decreases CBF, it maintains the cerebrovascular response to CO(2).


Negative_regulation (decreases) of CBF in blood
10) Confidence 0.38 Published 2001 Journal J Clin Anesth Section Body Doc Link 11755322 Disease Relevance 0 Pain Relevance 0
Premedication with morphine and atropine and local anesthesia with lidocaine hydrochloride significantly decreased the CBF.
Negative_regulation (decreased) of CBF associated with anesthesia, lidocaine and morphine
11) Confidence 0.38 Published 1991 Journal Ann. Otol. Rhinol. Laryngol. Section Abstract Doc Link 2024898 Disease Relevance 0 Pain Relevance 0.30
Long-term opioid dependence seems to decrease prefrontal CBF in particular.
Negative_regulation (decrease) of CBF in prefrontal associated with addiction and opioid
12) Confidence 0.38 Published 2002 Journal Neuropsychobiology Section Abstract Doc Link 11893862 Disease Relevance 0.17 Pain Relevance 0.85
All three examined volatile anesthetics significantly (P<0.01) increased CBF equivalent in a dose-dependent manner (0.5, 1.0, 1.5 MAC).
Negative_regulation (equivalent) of CBF
13) Confidence 0.38 Published 1996 Journal Anesthesiology Section Body Doc Link 8659783 Disease Relevance 0 Pain Relevance 0
RESULTS: CBF equivalent at 0.5 MAC of isoflurane, halothane, and sevoflurane was 21 +/- 4, 20 +/- 3, and 21 +/- 5 ml blood/ml oxygen, respectively.
Negative_regulation (equivalent) of CBF in blood
14) Confidence 0.38 Published 1996 Journal Anesthesiology Section Body Doc Link 8659783 Disease Relevance 0 Pain Relevance 0
When PaCO2 was lowered to 30 Torr, under 70% nitrous oxide + 1% enflurane, there was a 43% decrease in CBF (from a mean of 42 ml/100 G/min. to a mean of 24 ml/100 g/min.).
Negative_regulation (decrease) of CBF
15) Confidence 0.38 Published 1980 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 6779497 Disease Relevance 0.15 Pain Relevance 0.15
In some instances, the decrease in CBF reached values around 20 ml/100 g/min. and in one case, even less.
Negative_regulation (decrease) of CBF
16) Confidence 0.38 Published 1980 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 6779497 Disease Relevance 0.16 Pain Relevance 0.14
However, a complementary use of hypocapnia may reduce CBF to dangerously low levels, if at the start, it shows already a pathological decrease and if hyperventilation is applied at a marked degree.
Spec (may) Negative_regulation (reduce) of CBF associated with hypocapnia and dyspnea
17) Confidence 0.38 Published 1980 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 6779497 Disease Relevance 0.35 Pain Relevance 0.07
However, it decreases global cerebral blood flow (CBF) due to hyperventilation side effect of adenosine.
Negative_regulation (decreases) of CBF in blood associated with adenocard and dyspnea
18) Confidence 0.38 Published 2002 Journal Neuroimage Section Abstract Doc Link 12169262 Disease Relevance 0.56 Pain Relevance 0.18
Recent investigations demonstrate that cerebral blood flow (CBF) progressively declines during hypothermic, nonpulsatile cardiopulmonary bypass (CPB).
Negative_regulation (declines) of CBF in blood
19) Confidence 0.38 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1898686 Disease Relevance 0 Pain Relevance 0
Because sequential CBF measurements using xenon 133 (133Xe) clearance must be separated by 15-25 min, we hypothesized that a time-dependent decline in CBF would accentuate the CBF reduction caused by a decrease in PaCO2, but would blunt the CBF increase associated with a rise in PaCO2.
Negative_regulation (decline) of CBF
20) Confidence 0.38 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1898686 Disease Relevance 0 Pain Relevance 0

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