INT163974

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv1, Tnf) transport (Trpv1) intracellular (Tnf)
extracellular matrix organization (Tnf) transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
afferent neurons 2
Trpv1 (Mus musculus)
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 100.00 Very High Very High Very High
qutenza 3 98.92 Very High Very High Very High
cytokine 4 87.04 High High
Inflammation 4 75.00 Quite High
Neuropeptide 2 51.36 Quite High
Calcitonin gene-related peptide 1 49.36 Quite Low
antagonist 1 43.68 Quite Low
neuropeptide release 1 25.76 Quite Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 3 83.68 Quite High
INFLAMMATION 4 75.00 Quite High
Immunization 1 25.00 Low Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently demonstrated that SA13353 [1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea], a novel transient receptor potential vanilloid 1 (TRPV1) agonist, inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons.
TRPV1 Negative_regulation (inhibits) of Gene_expression (production) of TNF-alpha in afferent neurons associated with qutenza and agonist
1) Confidence 0.34 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19878665 Disease Relevance 0.24 Pain Relevance 0.35

General Comments

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